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The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia.
Pathol Int. 2013 May; 63(5):237-44.PI

Abstract

Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described neovascularization in COP and UIP, this aspect of UIP has not been compared with NSIP. In this study, we evaluated neovascularization in intra-alveolar fibrotic lesion of cases of fibrosing NSIP (f-NSIP) (n = 26) and UIP (n = 25). In the f-NSIP group, a considerable degree of neovascularization was observed compared to the UIP group and bud type intra-alveolar fibrosis showed a greater degree of neovascularization compared to the mural-incorporation and obliterative types of intra-alveolar fibrosis. Real-time reverse transcription polymerase chain reaction revealed a significantly greater expression of VEGF-A mRNA in f-NSIP than in UIP. The expression of matrix metalloproteinase-2 (MMP-2) mRNA also showed significantly higher in f-NSIP than UIP. The greater VEGF-A and MMP-2 expression may play a role in the pathogenesis of neovascularization in early intra-alveolar fibrotic lesions in f-NSIP.

Authors+Show Affiliations

Department of Analytic Human Pathology, Nippon Medical School, Tokyo 113-8602, Japan. onomk@nms.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23714250

Citation

Takahashi, Mikiko, et al. "The Difference of Neovascularization in Early Intra-alveolar Fibrosis Between Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia." Pathology International, vol. 63, no. 5, 2013, pp. 237-44.
Takahashi M, Kunugi S, Terasaki Y, et al. The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia. Pathol Int. 2013;63(5):237-44.
Takahashi, M., Kunugi, S., Terasaki, Y., Terasaki, M., Urushiyama, H., Kuwahara, N., Wakamatsu, K., Nakayama, T., & Fukuda, Y. (2013). The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia. Pathology International, 63(5), 237-44. https://doi.org/10.1111/pin.12058
Takahashi M, et al. The Difference of Neovascularization in Early Intra-alveolar Fibrosis Between Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia. Pathol Int. 2013;63(5):237-44. PubMed PMID: 23714250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The difference of neovascularization in early intra-alveolar fibrosis between nonspecific interstitial pneumonia and usual interstitial pneumonia. AU - Takahashi,Mikiko, AU - Kunugi,Shinobu, AU - Terasaki,Yasuhiro, AU - Terasaki,Mika, AU - Urushiyama,Hirokazu, AU - Kuwahara,Naomi, AU - Wakamatsu,Kyoko, AU - Nakayama,Tomoko, AU - Fukuda,Yuh, PY - 2012/10/17/received PY - 2013/04/16/accepted PY - 2013/5/30/entrez PY - 2013/5/30/pubmed PY - 2014/5/13/medline SP - 237 EP - 44 JF - Pathology international JO - Pathol. Int. VL - 63 IS - 5 N2 - Of the idiopathic interstitial pneumonias (IIPs), usual interstitial pneumonia (UIP) and diffuse alveolar damage (DAD) usually have poor prognoses. The prognoses of cryptogenic organizing pneumonia (COP) and nonspecific interstitial pneumonia (NSIP) are usually more favorable. Although several reports have described neovascularization in COP and UIP, this aspect of UIP has not been compared with NSIP. In this study, we evaluated neovascularization in intra-alveolar fibrotic lesion of cases of fibrosing NSIP (f-NSIP) (n = 26) and UIP (n = 25). In the f-NSIP group, a considerable degree of neovascularization was observed compared to the UIP group and bud type intra-alveolar fibrosis showed a greater degree of neovascularization compared to the mural-incorporation and obliterative types of intra-alveolar fibrosis. Real-time reverse transcription polymerase chain reaction revealed a significantly greater expression of VEGF-A mRNA in f-NSIP than in UIP. The expression of matrix metalloproteinase-2 (MMP-2) mRNA also showed significantly higher in f-NSIP than UIP. The greater VEGF-A and MMP-2 expression may play a role in the pathogenesis of neovascularization in early intra-alveolar fibrotic lesions in f-NSIP. SN - 1440-1827 UR - https://www.unboundmedicine.com/medline/citation/23714250/The_difference_of_neovascularization_in_early_intra_alveolar_fibrosis_between_nonspecific_interstitial_pneumonia_and_usual_interstitial_pneumonia_ L2 - https://doi.org/10.1111/pin.12058 DB - PRIME DP - Unbound Medicine ER -