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Dietary glycemic load and glycemic index and risk of cerebrovascular disease in the EPICOR cohort.
PLoS One 2013; 8(5):e62625Plos

Abstract

BACKGROUND

Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results.

OBJECTIVE

To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy.

DESIGN

We studied 44099 participants (13,646 men and 30,453 women) who completed a dietary questionnaire. Multivariable Cox modeling estimated adjusted hazard ratios (HRs) of stroke with 95% confidence intervals (95%CI). Over 11 years of follow-up, 355 stroke cases (195 ischemic and 83 hemorrhagic) were identified.

RESULTS

Increasing carbohydrate intake was associated with increasing stroke risk (HR = 2.01, 95%CI = 1.04-3.86 highest vs. lowest quintile; p for trend 0.025). Increasing carbohydrate intake from high-GI foods was also significantly associated with increasing stroke risk (HR 1.87, 95%CI = 1.16-3.02 highest vs. lowest, p trend 0.008), while increasing carbohydrate intake from low-GI foods was not. Increasing GL was associated with significantly increasing stroke risk (HR 2.21, 95%CI = 1.16-4.20, highest vs. lowest; p trend 0.015). Dietary carbohydrate from high GI foods was associated with increased both ischemic stroke risk (highest vs. lowest HR 1.92, 95%CI = 1.01-3.66) and hemorrhagic stroke risk (highest vs. lowest HR 3.14, 95%CI = 1.09-9.04). GL was associated with increased both ischemic and hemorrhagic stroke risk (HR 1.44, 95%CI = 1.09-1.92 and HR 1.56, 95%CI = 1.01-2.41 respectively, continuous variable).

CONCLUSIONS

In this Italian cohort, high dietary GL and carbohydrate from high GI foods consumption increase overall risk of stroke.

Authors+Show Affiliations

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. sabina.sieri@istitutotumori.mi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23717392

Citation

Sieri, Sabina, et al. "Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort." PloS One, vol. 8, no. 5, 2013, pp. e62625.
Sieri S, Brighenti F, Agnoli C, et al. Dietary glycemic load and glycemic index and risk of cerebrovascular disease in the EPICOR cohort. PLoS ONE. 2013;8(5):e62625.
Sieri, S., Brighenti, F., Agnoli, C., Grioni, S., Masala, G., Bendinelli, B., ... Krogh, V. (2013). Dietary glycemic load and glycemic index and risk of cerebrovascular disease in the EPICOR cohort. PloS One, 8(5), pp. e62625. doi:10.1371/journal.pone.0062625.
Sieri S, et al. Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort. PLoS ONE. 2013;8(5):e62625. PubMed PMID: 23717392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic load and glycemic index and risk of cerebrovascular disease in the EPICOR cohort. AU - Sieri,Sabina, AU - Brighenti,Furio, AU - Agnoli,Claudia, AU - Grioni,Sara, AU - Masala,Giovanna, AU - Bendinelli,Benedetta, AU - Sacerdote,Carlotta, AU - Ricceri,Fulvio, AU - Tumino,Rosario, AU - Giurdanella,Maria Concetta, AU - Pala,Valeria, AU - Berrino,Franco, AU - Mattiello,Amalia, AU - Chiodini,Paolo, AU - Panico,Salvatore, AU - Krogh,Vittorio, Y1 - 2013/05/23/ PY - 2012/12/05/received PY - 2013/03/22/accepted PY - 2013/5/30/entrez PY - 2013/5/30/pubmed PY - 2014/1/8/medline SP - e62625 EP - e62625 JF - PloS one JO - PLoS ONE VL - 8 IS - 5 N2 - BACKGROUND: Studies on the association of stroke risk to dietary glycemic index (GI) and glycemic load (GL) have produced contrasting results. OBJECTIVE: To investigate the relation of dietary GI and GL to stroke risk in the large EPIC-Italy cohort (EPICOR) recruited from widely dispersed geographic areas of Italy. DESIGN: We studied 44099 participants (13,646 men and 30,453 women) who completed a dietary questionnaire. Multivariable Cox modeling estimated adjusted hazard ratios (HRs) of stroke with 95% confidence intervals (95%CI). Over 11 years of follow-up, 355 stroke cases (195 ischemic and 83 hemorrhagic) were identified. RESULTS: Increasing carbohydrate intake was associated with increasing stroke risk (HR = 2.01, 95%CI = 1.04-3.86 highest vs. lowest quintile; p for trend 0.025). Increasing carbohydrate intake from high-GI foods was also significantly associated with increasing stroke risk (HR 1.87, 95%CI = 1.16-3.02 highest vs. lowest, p trend 0.008), while increasing carbohydrate intake from low-GI foods was not. Increasing GL was associated with significantly increasing stroke risk (HR 2.21, 95%CI = 1.16-4.20, highest vs. lowest; p trend 0.015). Dietary carbohydrate from high GI foods was associated with increased both ischemic stroke risk (highest vs. lowest HR 1.92, 95%CI = 1.01-3.66) and hemorrhagic stroke risk (highest vs. lowest HR 3.14, 95%CI = 1.09-9.04). GL was associated with increased both ischemic and hemorrhagic stroke risk (HR 1.44, 95%CI = 1.09-1.92 and HR 1.56, 95%CI = 1.01-2.41 respectively, continuous variable). CONCLUSIONS: In this Italian cohort, high dietary GL and carbohydrate from high GI foods consumption increase overall risk of stroke. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23717392/Dietary_glycemic_load_and_glycemic_index_and_risk_of_cerebrovascular_disease_in_the_EPICOR_cohort_ L2 - http://dx.plos.org/10.1371/journal.pone.0062625 DB - PRIME DP - Unbound Medicine ER -