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Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy.
PLoS One. 2013; 8(5):e63786.Plos

Abstract

PURPOSE

To use adaptive optics scanning laser ophthalmoscopy (AO-SLO) to quantify cone loss ratio in the foveola in order to assess foveal cone status and to investigate relationships between foveal structural abnormalities and visual function in patients with macular hole (MH) after surgery.

METHODS

We evaluated 10 normal eyes of 10 healthy volunteers and 19 eyes of 18 patients in whom anatomically successful MH closure had been performed. All subjects underwent a comprehensive ophthalmologic examination that included measurements of spectral-domain optical coherence tomography and AO-SLO.

RESULTS

On AO-SLO regular cone mosaic was seen in all normal eyes whereas dark regions suggesting cone loss were seen in all eyes after MH repair. Visual acuity was better in eyes without dark regions at the center of the fovea than in eyes with them (P = 0.001). Cone loss ratio in the foveola correlated with postoperative visual acuity (P<0.001), mean foveal sensitivity (P = 0.029), thinner inner and outer segments at the center of the fovea (P = 0.002), larger size of the disrupted inner and outer segment junction line (P = 0.018), and cone outer segment tip line (P<0.001). Cone loss ratio in the foveola was significantly greater in eyes that had moderately reflective foveal lesions after surgery (P = 0.006).

CONCLUSIONS

AO-SLO is a useful means of assessing foveal cone damage objectively and quantitatively. The location and extent of cone damage, especially if it involves the foveola, is an important factor determining visual function after MH surgery.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23717484

Citation

Yokota, Satoshi, et al. "Objective Assessment of Foveal Cone Loss Ratio in Surgically Closed Macular Holes Using Adaptive Optics Scanning Laser Ophthalmoscopy." PloS One, vol. 8, no. 5, 2013, pp. e63786.
Yokota S, Ooto S, Hangai M, et al. Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy. PLoS One. 2013;8(5):e63786.
Yokota, S., Ooto, S., Hangai, M., Takayama, K., Ueda-Arakawa, N., Yoshihara, Y., Hanebuchi, M., & Yoshimura, N. (2013). Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy. PloS One, 8(5), e63786. https://doi.org/10.1371/journal.pone.0063786
Yokota S, et al. Objective Assessment of Foveal Cone Loss Ratio in Surgically Closed Macular Holes Using Adaptive Optics Scanning Laser Ophthalmoscopy. PLoS One. 2013;8(5):e63786. PubMed PMID: 23717484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy. AU - Yokota,Satoshi, AU - Ooto,Sotaro, AU - Hangai,Masanori, AU - Takayama,Kohei, AU - Ueda-Arakawa,Naoko, AU - Yoshihara,Yuki, AU - Hanebuchi,Masaaki, AU - Yoshimura,Nagahisa, Y1 - 2013/05/24/ PY - 2013/02/21/received PY - 2013/04/05/accepted PY - 2013/5/30/entrez PY - 2013/5/30/pubmed PY - 2013/12/16/medline SP - e63786 EP - e63786 JF - PloS one JO - PLoS One VL - 8 IS - 5 N2 - PURPOSE: To use adaptive optics scanning laser ophthalmoscopy (AO-SLO) to quantify cone loss ratio in the foveola in order to assess foveal cone status and to investigate relationships between foveal structural abnormalities and visual function in patients with macular hole (MH) after surgery. METHODS: We evaluated 10 normal eyes of 10 healthy volunteers and 19 eyes of 18 patients in whom anatomically successful MH closure had been performed. All subjects underwent a comprehensive ophthalmologic examination that included measurements of spectral-domain optical coherence tomography and AO-SLO. RESULTS: On AO-SLO regular cone mosaic was seen in all normal eyes whereas dark regions suggesting cone loss were seen in all eyes after MH repair. Visual acuity was better in eyes without dark regions at the center of the fovea than in eyes with them (P = 0.001). Cone loss ratio in the foveola correlated with postoperative visual acuity (P<0.001), mean foveal sensitivity (P = 0.029), thinner inner and outer segments at the center of the fovea (P = 0.002), larger size of the disrupted inner and outer segment junction line (P = 0.018), and cone outer segment tip line (P<0.001). Cone loss ratio in the foveola was significantly greater in eyes that had moderately reflective foveal lesions after surgery (P = 0.006). CONCLUSIONS: AO-SLO is a useful means of assessing foveal cone damage objectively and quantitatively. The location and extent of cone damage, especially if it involves the foveola, is an important factor determining visual function after MH surgery. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23717484/Objective_assessment_of_foveal_cone_loss_ratio_in_surgically_closed_macular_holes_using_adaptive_optics_scanning_laser_ophthalmoscopy_ L2 - https://dx.plos.org/10.1371/journal.pone.0063786 DB - PRIME DP - Unbound Medicine ER -