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Family cluster of Middle East respiratory syndrome coronavirus infections.
N Engl J Med. 2013 Jun 27; 368(26):2487-94.NEJM

Abstract

A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients.

Authors+Show Affiliations

Global Center for Mass Gatherings Medicine, Ministry of Health, and Al-Faisal University, Riyadh, Saudi Arabia. zmemish@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23718156

Citation

Memish, Ziad A., et al. "Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections." The New England Journal of Medicine, vol. 368, no. 26, 2013, pp. 2487-94.
Memish ZA, Zumla AI, Al-Hakeem RF, et al. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med. 2013;368(26):2487-94.
Memish, Z. A., Zumla, A. I., Al-Hakeem, R. F., Al-Rabeeah, A. A., & Stephens, G. M. (2013). Family cluster of Middle East respiratory syndrome coronavirus infections. The New England Journal of Medicine, 368(26), 2487-94. https://doi.org/10.1056/NEJMoa1303729
Memish ZA, et al. Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections. N Engl J Med. 2013 Jun 27;368(26):2487-94. PubMed PMID: 23718156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Family cluster of Middle East respiratory syndrome coronavirus infections. AU - Memish,Ziad A, AU - Zumla,Alimuddin I, AU - Al-Hakeem,Rafat F, AU - Al-Rabeeah,Abdullah A, AU - Stephens,Gwen M, Y1 - 2013/05/29/ PY - 2013/5/31/entrez PY - 2013/5/31/pubmed PY - 2013/7/17/medline SP - 2487 EP - 94 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 368 IS - 26 N2 - A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/23718156/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJMoa1303729?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -