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Antemortem and postmortem methamphetamine blood concentrations: three case reports.

Abstract

We compare antemortem whole-blood to postmortem peripheral blood concentrations of methamphetamine and its metabolite amphetamine in three medical examiner cases. Antemortem specimens, initially screened positive for methamphetamine by ELISA, were subsequently confirmed, together with the postmortem specimens, by GC-MS analysis following solid-phase extraction. Methamphetamine peripheral blood to antemortem blood ratios averaged 1.51 (± 0.049; n = 3) and amphetamine peripheral blood to antemortem blood ratios averaged 1.50 (n = 2). These data show that postmortem redistribution occurs for both methamphetamine and amphetamine, revealing that postmortem blood concentrations are ∼1.5 times greater than antemortem concentrations. Furthermore, as both methamphetamine and amphetamine have previously been shown to have liver/peripheral blood (L/P) ratios of 5-8, it can be proposed that drugs displaying L/P ratios ranging from 5 to 10 may exhibit postmortem concentrations up to twice those concentrations circulating in blood before death.

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  • Authors+Show Affiliations

    ,

    Forensic Toxicology Laboratory, County of San Diego Medical Examiner's Office, 5570 Overland Ave., Suite 101, San Diego, CA 92123, USA. iain.mcintyre@sdcounty.ca.gov

    , ,

    Source

    MeSH

    Adult
    Amphetamine
    Enzyme-Linked Immunosorbent Assay
    Fatal Outcome
    Gas Chromatography-Mass Spectrometry
    Humans
    Male
    Methamphetamine
    Middle Aged
    Postmortem Changes
    Solid Phase Extraction
    Substance-Related Disorders

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    23719317

    Citation

    McIntyre, Iain M., et al. "Antemortem and Postmortem Methamphetamine Blood Concentrations: Three Case Reports." Journal of Analytical Toxicology, vol. 37, no. 6, 2013, pp. 386-9.
    McIntyre IM, Nelson CL, Schaber B, et al. Antemortem and postmortem methamphetamine blood concentrations: three case reports. J Anal Toxicol. 2013;37(6):386-9.
    McIntyre, I. M., Nelson, C. L., Schaber, B., & Hamm, C. E. (2013). Antemortem and postmortem methamphetamine blood concentrations: three case reports. Journal of Analytical Toxicology, 37(6), pp. 386-9. doi:10.1093/jat/bkt040.
    McIntyre IM, et al. Antemortem and Postmortem Methamphetamine Blood Concentrations: Three Case Reports. J Anal Toxicol. 2013;37(6):386-9. PubMed PMID: 23719317.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Antemortem and postmortem methamphetamine blood concentrations: three case reports. AU - McIntyre,Iain M, AU - Nelson,Craig L, AU - Schaber,Bethann, AU - Hamm,Catherine E, Y1 - 2013/05/29/ PY - 2013/5/31/entrez PY - 2013/5/31/pubmed PY - 2014/2/7/medline SP - 386 EP - 9 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 37 IS - 6 N2 - We compare antemortem whole-blood to postmortem peripheral blood concentrations of methamphetamine and its metabolite amphetamine in three medical examiner cases. Antemortem specimens, initially screened positive for methamphetamine by ELISA, were subsequently confirmed, together with the postmortem specimens, by GC-MS analysis following solid-phase extraction. Methamphetamine peripheral blood to antemortem blood ratios averaged 1.51 (± 0.049; n = 3) and amphetamine peripheral blood to antemortem blood ratios averaged 1.50 (n = 2). These data show that postmortem redistribution occurs for both methamphetamine and amphetamine, revealing that postmortem blood concentrations are ∼1.5 times greater than antemortem concentrations. Furthermore, as both methamphetamine and amphetamine have previously been shown to have liver/peripheral blood (L/P) ratios of 5-8, it can be proposed that drugs displaying L/P ratios ranging from 5 to 10 may exhibit postmortem concentrations up to twice those concentrations circulating in blood before death. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/23719317/Antemortem_and_postmortem_methamphetamine_blood_concentrations:_three_case_reports_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkt040 DB - PRIME DP - Unbound Medicine ER -