Tags

Type your tag names separated by a space and hit enter

Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial.
Am J Clin Nutr. 2013 Jul; 98(1):82-91.AJ

Abstract

BACKGROUND

Pregnancy and lactation in adolescents with habitually low calcium intake may adversely affect maternal bone mass.

OBJECTIVE

We investigated the effect of calcium plus vitamin D supplementation during pregnancy on bone mass during lactation in Brazilian adolescent mothers with low-calcium diets (∼600 mg/d).

DESIGN

Pregnant adolescents (14-19 y) randomly received daily calcium (600 mg) plus vitamin D3 (200 IU) (n = 30) or a placebo (n = 26) from 26 wk of pregnancy (baseline) until parturition. The bone mineral content (BMC), bone area (BA), and bone mineral density (BMD) at the total body, lumbar spine, and hip (total and femoral neck) were evaluated by using dual-energy X-ray absorptiometry at 5 and 20 wk postpartum. Serum hormones and 25-hydroxyvitamin D [25(OH)D] were measured. Group comparisons were adjusted for significant covariates.

RESULTS

The mean serum 25(OH)D concentration was 59 nmol/L at baseline. In comparison with the placebo, 25(OH)D tended to be 14-15 nmol/L higher postpartum in the supplemented group (P = 0.08). Total body and hip BMC and BMD decreased over time (P ≤ 0.005) in both groups with a group × time interaction at the femoral neck (P < 0.04). Supplemented mothers had higher lumbar spine BA (6.7%; P = 0.002) and lumbar spine BMC (7.9%, P = 0.08) than did mothers who consumed the placebo at 5 wk postpartum. At 20 wk postpartum, differences between groups were more evident, with higher lumbar spine BMC (13.9%), lumbar spine BA (6.2%), and lumbar spine BMD (10.6%) in the supplemented group (P ≤ 0.008).

CONCLUSIONS

Calcium plus vitamin D supplementation during pregnancy of adolescents with low calcium intake results in higher lumbar spine bone mass and a reduced rate of femoral neck bone loss during lactation. Additional studies are required to determine whether bone effects are temporary or long-lasting. This trial was registered at clinicaltrials.gov as NCT01732328.

Authors+Show Affiliations

Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química and the Maternidade Escola, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23719547

Citation

Diogenes, Maria Eduarda L., et al. "Effect of Calcium Plus Vitamin D Supplementation During Pregnancy in Brazilian Adolescent Mothers: a Randomized, Placebo-controlled Trial." The American Journal of Clinical Nutrition, vol. 98, no. 1, 2013, pp. 82-91.
Diogenes ME, Bezerra FF, Rezende EP, et al. Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial. Am J Clin Nutr. 2013;98(1):82-91.
Diogenes, M. E., Bezerra, F. F., Rezende, E. P., Taveira, M. F., Pinhal, I., & Donangelo, C. M. (2013). Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial. The American Journal of Clinical Nutrition, 98(1), 82-91. https://doi.org/10.3945/ajcn.112.056275
Diogenes ME, et al. Effect of Calcium Plus Vitamin D Supplementation During Pregnancy in Brazilian Adolescent Mothers: a Randomized, Placebo-controlled Trial. Am J Clin Nutr. 2013;98(1):82-91. PubMed PMID: 23719547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial. AU - Diogenes,Maria Eduarda L, AU - Bezerra,Flávia F, AU - Rezende,Elaine P, AU - Taveira,Marcia Fernanda, AU - Pinhal,Isabel, AU - Donangelo,Carmen M, Y1 - 2013/05/29/ PY - 2013/5/31/entrez PY - 2013/5/31/pubmed PY - 2013/8/27/medline SP - 82 EP - 91 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 98 IS - 1 N2 - BACKGROUND: Pregnancy and lactation in adolescents with habitually low calcium intake may adversely affect maternal bone mass. OBJECTIVE: We investigated the effect of calcium plus vitamin D supplementation during pregnancy on bone mass during lactation in Brazilian adolescent mothers with low-calcium diets (∼600 mg/d). DESIGN: Pregnant adolescents (14-19 y) randomly received daily calcium (600 mg) plus vitamin D3 (200 IU) (n = 30) or a placebo (n = 26) from 26 wk of pregnancy (baseline) until parturition. The bone mineral content (BMC), bone area (BA), and bone mineral density (BMD) at the total body, lumbar spine, and hip (total and femoral neck) were evaluated by using dual-energy X-ray absorptiometry at 5 and 20 wk postpartum. Serum hormones and 25-hydroxyvitamin D [25(OH)D] were measured. Group comparisons were adjusted for significant covariates. RESULTS: The mean serum 25(OH)D concentration was 59 nmol/L at baseline. In comparison with the placebo, 25(OH)D tended to be 14-15 nmol/L higher postpartum in the supplemented group (P = 0.08). Total body and hip BMC and BMD decreased over time (P ≤ 0.005) in both groups with a group × time interaction at the femoral neck (P < 0.04). Supplemented mothers had higher lumbar spine BA (6.7%; P = 0.002) and lumbar spine BMC (7.9%, P = 0.08) than did mothers who consumed the placebo at 5 wk postpartum. At 20 wk postpartum, differences between groups were more evident, with higher lumbar spine BMC (13.9%), lumbar spine BA (6.2%), and lumbar spine BMD (10.6%) in the supplemented group (P ≤ 0.008). CONCLUSIONS: Calcium plus vitamin D supplementation during pregnancy of adolescents with low calcium intake results in higher lumbar spine bone mass and a reduced rate of femoral neck bone loss during lactation. Additional studies are required to determine whether bone effects are temporary or long-lasting. This trial was registered at clinicaltrials.gov as NCT01732328. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/23719547/Effect_of_calcium_plus_vitamin_D_supplementation_during_pregnancy_in_Brazilian_adolescent_mothers:_a_randomized_placebo_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.056275 DB - PRIME DP - Unbound Medicine ER -