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Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats.
Toxicol Ind Health. 2015 Dec; 31(12):1185-94.TI

Abstract

The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the induction of painful neuropathy. Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day. Furthermore, the biochemical changes, that is, thiobarbituric acid-reactive substances, reduced glutathione, and total calcium levels have been estimated in sciatic nerve tissue on 24th day and histopathological changes have been observed in sciatic nerve tissue sample. MESM and pregabalin have been administered for 14 consecutive days before 1 h of the each acrylamide injection. Administration of acrylamide resulted in significant changes in behavioral and biochemical parameters. Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. These findings suggested that the neuroprotective effect of S. mahagoni may be due to its potential of antioxidative, calcium channel modulatory, and neuroprotective action.

Authors+Show Affiliations

Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India arunachalammu@gmail.com.Karolinska Institutet, Solna, Sweden.Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23719848

Citation

Vanitha, Subburaj, et al. "Pharmacological Evaluation of Methanolic Leaf Extract of Swietenia Mahagoni On Acrylamide-induced Neuropathic Pain in Rats." Toxicology and Industrial Health, vol. 31, no. 12, 2015, pp. 1185-94.
Vanitha S, Thiagarajan VR, Muthuraman A, et al. Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats. Toxicol Ind Health. 2015;31(12):1185-94.
Vanitha, S., Thiagarajan, V. R., Muthuraman, A., Krishnan, S., Aruna, A., & Tharabai, R. (2015). Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats. Toxicology and Industrial Health, 31(12), 1185-94. https://doi.org/10.1177/0748233713491808
Vanitha S, et al. Pharmacological Evaluation of Methanolic Leaf Extract of Swietenia Mahagoni On Acrylamide-induced Neuropathic Pain in Rats. Toxicol Ind Health. 2015;31(12):1185-94. PubMed PMID: 23719848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats. AU - Vanitha,Subburaj, AU - Thiagarajan,Venkata Rathina Kumar, AU - Muthuraman,Arunachalam, AU - Krishnan,Shanmugarajan, AU - Aruna,Ajithadas, AU - Tharabai,R, Y1 - 2013/05/29/ PY - 2013/5/31/entrez PY - 2013/5/31/pubmed PY - 2016/9/17/medline KW - Acrylamide KW - Swietenia mahagoni KW - calcium KW - neuropathic pain KW - neuroprotection KW - oxidative stress SP - 1185 EP - 94 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 31 IS - 12 N2 - The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the induction of painful neuropathy. Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day. Furthermore, the biochemical changes, that is, thiobarbituric acid-reactive substances, reduced glutathione, and total calcium levels have been estimated in sciatic nerve tissue on 24th day and histopathological changes have been observed in sciatic nerve tissue sample. MESM and pregabalin have been administered for 14 consecutive days before 1 h of the each acrylamide injection. Administration of acrylamide resulted in significant changes in behavioral and biochemical parameters. Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. These findings suggested that the neuroprotective effect of S. mahagoni may be due to its potential of antioxidative, calcium channel modulatory, and neuroprotective action. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/23719848/Pharmacological_evaluation_of_methanolic_leaf_extract_of_Swietenia_mahagoni_on_acrylamide_induced_neuropathic_pain_in_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0748233713491808?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -