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Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients.
Clin Transpl. 2012CT

Abstract

Previous reports using cell-based methods (CDC-AHG) suggest that the presence of pre-transplant HLA Class I and II antibodies are associated with worse survival following lung transplantation. Similarly, antibodies to major histocompatibility complex Class I chain-related gene A (MICA) have been associated with increased graft failure following kidney transplantation. Using highly sensitive solid phase assays, we sought to determine whether the pre-transplant presence of antibodies to MICA or HLA Class I or II predicted short or long-term lung allograft function. Pre-transplant sera screened for antibodies to MICA by Labscreen Single Antigen format and HLA by Luminex (n = 192) revealed antibody presence in 31 (16.1%) and 70 (36.4%) patients, respectively. HLA antibody presence correlated with increased bronchiolitis Obliterans syndrome (BOS)-1 development at 3 years [32.9% (23/70) vs. 18.9% (23/122), p = 0.03] while MICA antibodies correlated with BOS-2 development [32.3% (10/31) vs. 14.9% (24/161), p = 0.02]. The presence of HLA or MICA antibodies correlated with BOS-1 development [32.5% (26/81) vs.18.0% (20/111), p = 0.02] and BOS-2 [24.7% (20/81) vs. 12.6% (14/111), p = 0.02] at 3 years. We found no correlation between antibody presence and episodes of acute cellular rejection or overall survival. We conclude that the presence of pre-transplant HLA or MICA antibodies is associated with earlier BOS onset following lung transplantation.

Authors+Show Affiliations

University of Colorado Denver, Aurora, Colorado, USA. dennis.lyu@ucdenver.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23721028

Citation

Lyu, Dennis M., et al. "Pre-transplant Presence of Antibodies to MICA and HLA Class I or II Are Associated With an Earlier Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients." Clinical Transplants, 2012, pp. 237-46.
Lyu DM, Grazia TJ, Benson AB, et al. Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients. Clin Transpl. 2012.
Lyu, D. M., Grazia, T. J., Benson, A. B., Cagle, L. R., Freed, B. M., & Zamora, M. R. (2012). Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients. Clinical Transplants, 237-46.
Lyu DM, et al. Pre-transplant Presence of Antibodies to MICA and HLA Class I or II Are Associated With an Earlier Onset of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients. Clin Transpl. 2012;237-46. PubMed PMID: 23721028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients. AU - Lyu,Dennis M, AU - Grazia,Todd J, AU - Benson,Alex B, AU - Cagle,Linda R, AU - Freed,Brian M, AU - Zamora,Martin R, PY - 2013/6/1/entrez PY - 2012/1/1/pubmed PY - 2013/6/21/medline SP - 237 EP - 46 JF - Clinical transplants JO - Clin Transpl N2 - Previous reports using cell-based methods (CDC-AHG) suggest that the presence of pre-transplant HLA Class I and II antibodies are associated with worse survival following lung transplantation. Similarly, antibodies to major histocompatibility complex Class I chain-related gene A (MICA) have been associated with increased graft failure following kidney transplantation. Using highly sensitive solid phase assays, we sought to determine whether the pre-transplant presence of antibodies to MICA or HLA Class I or II predicted short or long-term lung allograft function. Pre-transplant sera screened for antibodies to MICA by Labscreen Single Antigen format and HLA by Luminex (n = 192) revealed antibody presence in 31 (16.1%) and 70 (36.4%) patients, respectively. HLA antibody presence correlated with increased bronchiolitis Obliterans syndrome (BOS)-1 development at 3 years [32.9% (23/70) vs. 18.9% (23/122), p = 0.03] while MICA antibodies correlated with BOS-2 development [32.3% (10/31) vs. 14.9% (24/161), p = 0.02]. The presence of HLA or MICA antibodies correlated with BOS-1 development [32.5% (26/81) vs.18.0% (20/111), p = 0.02] and BOS-2 [24.7% (20/81) vs. 12.6% (14/111), p = 0.02] at 3 years. We found no correlation between antibody presence and episodes of acute cellular rejection or overall survival. We conclude that the presence of pre-transplant HLA or MICA antibodies is associated with earlier BOS onset following lung transplantation. SN - 0890-9016 UR - https://www.unboundmedicine.com/medline/citation/23721028/Pre_transplant_presence_of_antibodies_to_MICA_and_HLA_class_I_or_II_are_associated_with_an_earlier_onset_of_bronchiolitis_obliterans_syndrome_in_lung_transplant_recipients_ L2 - https://terasaki.org/store/CH23-Lyu DB - PRIME DP - Unbound Medicine ER -