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Paediatric community-associated Staphylococcus aureus: a retrospective cohort study.
J Paediatr Child Health 2013; 49(9):754-9JP

Abstract

AIM

We aimed to characterise the demographic and clinical features of paediatric community-associated Staphylococcus aureus (CA-SA) infection. We aimed to identify factors associated with methicillin-resistant S.aureus (MRSA) infection evident at the point of care with the potential to guide antibiotic choice.

METHODS

A retrospective chart review in 2008 of CA-SA infections at the Children's Hospital at Westmead (CHW), a 300-bed tertiary paediatric hospital in western Sydney, Australia. We calculate rates of MRSA and perform univariate and multivariate analysis for predictors of MRSA.

RESULTS

Of 431 patients with CA-SA infections, 19.3% were MRSA. In univariate analysis, MRSA was predicted by age greater than 1 year, Aboriginal race, rural/regional residence, previous history of skin and soft tissue infection (SSTI) or a family history of SSTI, at least 48 h of antibiotics active against methicillin-sensitive S.aureus (MSSA), invasive infection and abscess formation. In a multivariate analysis factors that independently predicted MRSA in the entire cohort, and in the non-invasive subgroup included abscess formation, a family history of staphylococcal infection or SSTI, Aboriginal ethnicity, at least 48 h of anti-MSSA antibiotics at presentation, presentation during spring and age greater than 1 year.

CONCLUSIONS

One fifth of CA-SA infections at our tertiary paediatric hospital in 2008 were MRSA. Several clinical and demographic factors evident at the point of care were highly significant predictors of CA-MRSA infection.

Authors+Show Affiliations

Department of Microbiology and Infectious Diseases, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; Discipline of Paediatrics and Child Health, The University of Sydney, Sydney, New South Wales, Australia.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23721234

Citation

Britton, Philip N., and David N. Andresen. "Paediatric Community-associated Staphylococcus Aureus: a Retrospective Cohort Study." Journal of Paediatrics and Child Health, vol. 49, no. 9, 2013, pp. 754-9.
Britton PN, Andresen DN. Paediatric community-associated Staphylococcus aureus: a retrospective cohort study. J Paediatr Child Health. 2013;49(9):754-9.
Britton, P. N., & Andresen, D. N. (2013). Paediatric community-associated Staphylococcus aureus: a retrospective cohort study. Journal of Paediatrics and Child Health, 49(9), pp. 754-9. doi:10.1111/jpc.12255.
Britton PN, Andresen DN. Paediatric Community-associated Staphylococcus Aureus: a Retrospective Cohort Study. J Paediatr Child Health. 2013;49(9):754-9. PubMed PMID: 23721234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paediatric community-associated Staphylococcus aureus: a retrospective cohort study. AU - Britton,Philip N, AU - Andresen,David N, Y1 - 2013/05/30/ PY - 2013/01/14/accepted PY - 2013/6/1/entrez PY - 2013/6/1/pubmed PY - 2014/5/3/medline KW - Staphylococcus aureus KW - general paediatrics KW - infectious diseases KW - skin and soft tissue infection SP - 754 EP - 9 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 49 IS - 9 N2 - AIM: We aimed to characterise the demographic and clinical features of paediatric community-associated Staphylococcus aureus (CA-SA) infection. We aimed to identify factors associated with methicillin-resistant S.aureus (MRSA) infection evident at the point of care with the potential to guide antibiotic choice. METHODS: A retrospective chart review in 2008 of CA-SA infections at the Children's Hospital at Westmead (CHW), a 300-bed tertiary paediatric hospital in western Sydney, Australia. We calculate rates of MRSA and perform univariate and multivariate analysis for predictors of MRSA. RESULTS: Of 431 patients with CA-SA infections, 19.3% were MRSA. In univariate analysis, MRSA was predicted by age greater than 1 year, Aboriginal race, rural/regional residence, previous history of skin and soft tissue infection (SSTI) or a family history of SSTI, at least 48 h of antibiotics active against methicillin-sensitive S.aureus (MSSA), invasive infection and abscess formation. In a multivariate analysis factors that independently predicted MRSA in the entire cohort, and in the non-invasive subgroup included abscess formation, a family history of staphylococcal infection or SSTI, Aboriginal ethnicity, at least 48 h of anti-MSSA antibiotics at presentation, presentation during spring and age greater than 1 year. CONCLUSIONS: One fifth of CA-SA infections at our tertiary paediatric hospital in 2008 were MRSA. Several clinical and demographic factors evident at the point of care were highly significant predictors of CA-MRSA infection. SN - 1440-1754 UR - https://www.unboundmedicine.com/medline/citation/23721234/Paediatric_community_associated_Staphylococcus_aureus:_a_retrospective_cohort_study_ L2 - https://doi.org/10.1111/jpc.12255 DB - PRIME DP - Unbound Medicine ER -