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Freestanding graphene paper decorated with 2D-assembly of Au@Pt nanoparticles as flexible biosensors to monitor live cell secretion of nitric oxide.
Biosens Bioelectron. 2013 Nov 15; 49:71-8.BB

Abstract

We report the development of a new type of flexible electrochemical biosensors based on graphene paper loaded with closely-packed Au@Pt core-shell nanoparticles as a freestanding cell culture substrate for real-time monitoring cell secretion of nitric oxide. The hybrid electrode was fabricated through a modular approach in which 2D-assembly of nanoparticles formed at the oil-water interface was transferred onto graphene paper by dip-coating. We have shown that the independently optimized metal nanostructures and graphene paper were integrated into functional electrodes with high electrocatalytic activity. When used for the detection of nitric oxide, the flexible electrodes have demonstrated high sensitivity, a wide linear range, and a low detection limit, which, in combination with its biocompatibility, offer unique opportunities for the real-time monitoring of nitric oxide secretion by human endothelial vein cells grown on the electrode. These interesting findings collectively demonstrate the potential of our modular approach for designing high-performance flexible electrodes with tailored surface properties.

Authors+Show Affiliations

School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23722044

Citation

Zan, Xiaoli, et al. "Freestanding Graphene Paper Decorated With 2D-assembly of Au@Pt Nanoparticles as Flexible Biosensors to Monitor Live Cell Secretion of Nitric Oxide." Biosensors & Bioelectronics, vol. 49, 2013, pp. 71-8.
Zan X, Fang Z, Wu J, et al. Freestanding graphene paper decorated with 2D-assembly of Au@Pt nanoparticles as flexible biosensors to monitor live cell secretion of nitric oxide. Biosens Bioelectron. 2013;49:71-8.
Zan, X., Fang, Z., Wu, J., Xiao, F., Huo, F., & Duan, H. (2013). Freestanding graphene paper decorated with 2D-assembly of Au@Pt nanoparticles as flexible biosensors to monitor live cell secretion of nitric oxide. Biosensors & Bioelectronics, 49, 71-8. https://doi.org/10.1016/j.bios.2013.05.006
Zan X, et al. Freestanding Graphene Paper Decorated With 2D-assembly of Au@Pt Nanoparticles as Flexible Biosensors to Monitor Live Cell Secretion of Nitric Oxide. Biosens Bioelectron. 2013 Nov 15;49:71-8. PubMed PMID: 23722044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Freestanding graphene paper decorated with 2D-assembly of Au@Pt nanoparticles as flexible biosensors to monitor live cell secretion of nitric oxide. AU - Zan,Xiaoli, AU - Fang,Zheng, AU - Wu,Jin, AU - Xiao,Fei, AU - Huo,Fengwei, AU - Duan,Hongwei, Y1 - 2013/05/09/ PY - 2013/02/19/received PY - 2013/04/07/revised PY - 2013/05/02/accepted PY - 2013/6/1/entrez PY - 2013/6/1/pubmed PY - 2014/2/14/medline KW - Core–shell nanoparticles KW - Flexible biosensors KW - Graphene paper KW - Live cell KW - Nitric oxide SP - 71 EP - 8 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 49 N2 - We report the development of a new type of flexible electrochemical biosensors based on graphene paper loaded with closely-packed Au@Pt core-shell nanoparticles as a freestanding cell culture substrate for real-time monitoring cell secretion of nitric oxide. The hybrid electrode was fabricated through a modular approach in which 2D-assembly of nanoparticles formed at the oil-water interface was transferred onto graphene paper by dip-coating. We have shown that the independently optimized metal nanostructures and graphene paper were integrated into functional electrodes with high electrocatalytic activity. When used for the detection of nitric oxide, the flexible electrodes have demonstrated high sensitivity, a wide linear range, and a low detection limit, which, in combination with its biocompatibility, offer unique opportunities for the real-time monitoring of nitric oxide secretion by human endothelial vein cells grown on the electrode. These interesting findings collectively demonstrate the potential of our modular approach for designing high-performance flexible electrodes with tailored surface properties. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/23722044/Freestanding_graphene_paper_decorated_with_2D_assembly_of_Au@Pt_nanoparticles_as_flexible_biosensors_to_monitor_live_cell_secretion_of_nitric_oxide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(13)00320-5 DB - PRIME DP - Unbound Medicine ER -