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Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature--preventable causes of AKI and SORO-ESRD--a call for re-engineering of nephrology practice paradigms.
Ren Fail. 2013 Jul; 35(6):796-800.RF

Abstract

INTRODUCTION

We described the previously unrecognized syndrome of rapid-onset end-stage renal disease (SORO-ESRD) in 2010, in the journal Renal Failure, as distinct from the classic CKD-ESRD progression of a methodical, linear, time-dependent and predictable progression from CKD through CKD stages I-V, ending in ESRD requiring renal replacement therapy (RRT). It remains unclear to what extent this syndrome may have been identified in the past without acknowledging its uniqueness.

METHODS

We reviewed AKI reports and ascertained cases of SORO-ESRD as defined by patients with a priori stable kidney function who subsequently exhibited unanticipated and irreversible ESRD requiring RRT following new AKI episodes.

RESULTS

Fifteen AKI reports demonstrating SORO-ESRD were analyzed. The reports span most regions of the world. The 15 studies with 20 to 1095 AKI patients each, mean age 39-65 years, published between 1975 and 2010, demonstrated SORO-ESRD rates from 1% to 85% of the AKI series. AKI was caused by hypovolemia/hypotension, infections/sepsis and exposure to nephrotoxics especially radiocontrast, NSAIDs, aminoglycosides and RAAS blocking agents, ACEIs and ARBs.

DISCUSSION

Irreversible ESRD following AKI, consistent with our recent description of a new and unrecognized syndrome has been sporadically reported in the AKI literature, without a clear mandate as a syndrome, potentially distinct from the classic ESRD. The contribution of SORO-ESRD to the global ESRD pandemic, the impact of SORO-ESRD on AV-Fistula planning, any differential behavior of SORO-ESRD versus classic ESRD in terms of mortality outcomes and any predisposing factors to SORO-ESRD as advanced age and nephrotoxic exposure all call for serious research study.

Authors+Show Affiliations

Department of Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA. onuigbo.macaulay@mayo.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23725089

Citation

Onuigbo, Macaulay A C.. "Evidence of the Syndrome of Rapid Onset End-stage Renal Disease (SORO-ESRD) in the Acute Kidney Injury (AKI) Literature--preventable Causes of AKI and SORO-ESRD--a Call for Re-engineering of Nephrology Practice Paradigms." Renal Failure, vol. 35, no. 6, 2013, pp. 796-800.
Onuigbo MA. Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature--preventable causes of AKI and SORO-ESRD--a call for re-engineering of nephrology practice paradigms. Ren Fail. 2013;35(6):796-800.
Onuigbo, M. A. (2013). Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature--preventable causes of AKI and SORO-ESRD--a call for re-engineering of nephrology practice paradigms. Renal Failure, 35(6), 796-800. https://doi.org/10.3109/0886022X.2013.800459
Onuigbo MA. Evidence of the Syndrome of Rapid Onset End-stage Renal Disease (SORO-ESRD) in the Acute Kidney Injury (AKI) Literature--preventable Causes of AKI and SORO-ESRD--a Call for Re-engineering of Nephrology Practice Paradigms. Ren Fail. 2013;35(6):796-800. PubMed PMID: 23725089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of the syndrome of rapid onset end-stage renal disease (SORO-ESRD) in the acute kidney injury (AKI) literature--preventable causes of AKI and SORO-ESRD--a call for re-engineering of nephrology practice paradigms. A1 - Onuigbo,Macaulay A C, Y1 - 2013/06/03/ PY - 2013/6/4/entrez PY - 2013/6/4/pubmed PY - 2014/3/4/medline SP - 796 EP - 800 JF - Renal failure JO - Ren Fail VL - 35 IS - 6 N2 - INTRODUCTION: We described the previously unrecognized syndrome of rapid-onset end-stage renal disease (SORO-ESRD) in 2010, in the journal Renal Failure, as distinct from the classic CKD-ESRD progression of a methodical, linear, time-dependent and predictable progression from CKD through CKD stages I-V, ending in ESRD requiring renal replacement therapy (RRT). It remains unclear to what extent this syndrome may have been identified in the past without acknowledging its uniqueness. METHODS: We reviewed AKI reports and ascertained cases of SORO-ESRD as defined by patients with a priori stable kidney function who subsequently exhibited unanticipated and irreversible ESRD requiring RRT following new AKI episodes. RESULTS: Fifteen AKI reports demonstrating SORO-ESRD were analyzed. The reports span most regions of the world. The 15 studies with 20 to 1095 AKI patients each, mean age 39-65 years, published between 1975 and 2010, demonstrated SORO-ESRD rates from 1% to 85% of the AKI series. AKI was caused by hypovolemia/hypotension, infections/sepsis and exposure to nephrotoxics especially radiocontrast, NSAIDs, aminoglycosides and RAAS blocking agents, ACEIs and ARBs. DISCUSSION: Irreversible ESRD following AKI, consistent with our recent description of a new and unrecognized syndrome has been sporadically reported in the AKI literature, without a clear mandate as a syndrome, potentially distinct from the classic ESRD. The contribution of SORO-ESRD to the global ESRD pandemic, the impact of SORO-ESRD on AV-Fistula planning, any differential behavior of SORO-ESRD versus classic ESRD in terms of mortality outcomes and any predisposing factors to SORO-ESRD as advanced age and nephrotoxic exposure all call for serious research study. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/23725089/Evidence_of_the_syndrome_of_rapid_onset_end_stage_renal_disease__SORO_ESRD__in_the_acute_kidney_injury__AKI__literature__preventable_causes_of_AKI_and_SORO_ESRD__a_call_for_re_engineering_of_nephrology_practice_paradigms_ DB - PRIME DP - Unbound Medicine ER -