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Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats.
Toxicol Appl Pharmacol. 2013 Oct 01; 272(1):208-20.TA

Abstract

It was investigated whether protective influence of zinc (Zn) against cadmium (Cd)-induced disorders in bone metabolism may be related to its antioxidative properties and impact on the receptor activator of nuclear factor (NF)-κΒ (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. Numerous indices of oxidative/antioxidative status, and Cd and Zn were determined in the distal femur of the rats administered Zn (30 and 60mg/l) or/and Cd (5 and 50mg/l) for 6months. Soluble RANKL (sRANKL) and OPG were measured in the bone and serum. Zn supplementation importantly protected from Cd-induced oxidative stress preventing protein, DNA, and lipid oxidation in the bone. Moreover, Zn protected from the Cd-induced increase in sRANKL concentration and the sRANKL/OPG ratio, and decrease in OPG concentration in the bone and serum. Numerous correlations were noted between indices of the oxidative/antioxidative bone status, concentrations of sRANKL and OPG in the bone and serum, as well as the bone concentrations of Zn and Cd, and previously reported by us in these animals (Brzóska et al., 2007) indices of bone turnover and bone mineral density. The results allow us to conclude that the ability of Zn to prevent from oxidative stress and the RANK/RANKL/OPG system imbalance may be implicated in the mechanisms of its protective impact against Cd-induced bone damage. This paper is the first report from an in vivo study providing evidence that beneficial Zn impact on the skeleton under exposure to Cd is related to the improvement of the bone tissue oxidative/antioxidative status and mediating the RANK/RANKL/OPG system.

Authors+Show Affiliations

Department of Toxicology, Medical University of Bialystok, Adama Mickiewicza 2C Street, 15-222 Bialystok, Poland. Electronic address: Malgorzata.Brzoska@umb.edu.pl.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23726800

Citation

Brzóska, Malgorzata M., and Joanna Rogalska. "Protective Effect of Zinc Supplementation Against Cadmium-induced Oxidative Stress and the RANK/RANKL/OPG System Imbalance in the Bone Tissue of Rats." Toxicology and Applied Pharmacology, vol. 272, no. 1, 2013, pp. 208-20.
Brzóska MM, Rogalska J. Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. Toxicol Appl Pharmacol. 2013;272(1):208-20.
Brzóska, M. M., & Rogalska, J. (2013). Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. Toxicology and Applied Pharmacology, 272(1), 208-20. https://doi.org/10.1016/j.taap.2013.05.016
Brzóska MM, Rogalska J. Protective Effect of Zinc Supplementation Against Cadmium-induced Oxidative Stress and the RANK/RANKL/OPG System Imbalance in the Bone Tissue of Rats. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):208-20. PubMed PMID: 23726800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. AU - Brzóska,Malgorzata M, AU - Rogalska,Joanna, Y1 - 2013/05/30/ PY - 2013/01/11/received PY - 2013/05/14/revised PY - 2013/05/20/accepted PY - 2013/6/4/entrez PY - 2013/6/4/pubmed PY - 2013/11/13/medline KW - 8-OHdG KW - 8-hydroxy-2′-deoxyguanosine KW - BMD KW - Bone tissue KW - CAT KW - CTX KW - Cadmium KW - Cd KW - Cu KW - Fe KW - GPx KW - GR KW - GSH KW - H(2)O(2) KW - LPO KW - Mn KW - OC KW - OPG KW - OSI KW - Oxidative stress KW - P-SH KW - PC KW - Protection KW - RANK/RANKL/OPG system KW - ROS KW - SOD KW - T-SH KW - TAS KW - TOS KW - Zinc KW - Zn KW - bone mineral density KW - cadmium KW - carboxy-terminal cross-linking telopeptides of type I collagen KW - catalase KW - copper KW - glutathione peroxidase KW - glutathione reductase KW - hydrogen peroxide KW - iron KW - lipid peroxides KW - manganese KW - osteocalcin KW - osteoprotegerin KW - oxidative stress index KW - protein carbonyl groups KW - protein thiol groups KW - reactive oxygen species KW - reduced glutathione KW - sRANKL KW - sRANKL/OPG KW - soluble receptor activator of nuclear factor-κΒ KW - superoxide dismutase KW - the ratio of sRANKL and OPG KW - total antioxidative status KW - total oxidative status KW - total thiol groups KW - zinc SP - 208 EP - 20 JF - Toxicology and applied pharmacology JO - Toxicol Appl Pharmacol VL - 272 IS - 1 N2 - It was investigated whether protective influence of zinc (Zn) against cadmium (Cd)-induced disorders in bone metabolism may be related to its antioxidative properties and impact on the receptor activator of nuclear factor (NF)-κΒ (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system. Numerous indices of oxidative/antioxidative status, and Cd and Zn were determined in the distal femur of the rats administered Zn (30 and 60mg/l) or/and Cd (5 and 50mg/l) for 6months. Soluble RANKL (sRANKL) and OPG were measured in the bone and serum. Zn supplementation importantly protected from Cd-induced oxidative stress preventing protein, DNA, and lipid oxidation in the bone. Moreover, Zn protected from the Cd-induced increase in sRANKL concentration and the sRANKL/OPG ratio, and decrease in OPG concentration in the bone and serum. Numerous correlations were noted between indices of the oxidative/antioxidative bone status, concentrations of sRANKL and OPG in the bone and serum, as well as the bone concentrations of Zn and Cd, and previously reported by us in these animals (Brzóska et al., 2007) indices of bone turnover and bone mineral density. The results allow us to conclude that the ability of Zn to prevent from oxidative stress and the RANK/RANKL/OPG system imbalance may be implicated in the mechanisms of its protective impact against Cd-induced bone damage. This paper is the first report from an in vivo study providing evidence that beneficial Zn impact on the skeleton under exposure to Cd is related to the improvement of the bone tissue oxidative/antioxidative status and mediating the RANK/RANKL/OPG system. SN - 1096-0333 UR - https://www.unboundmedicine.com/medline/citation/23726800/Protective_effect_of_zinc_supplementation_against_cadmium_induced_oxidative_stress_and_the_RANK/RANKL/OPG_system_imbalance_in_the_bone_tissue_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-008X(13)00233-0 DB - PRIME DP - Unbound Medicine ER -