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Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography.
Neuroimage. 2013 Nov 15; 82:252-9.N

Abstract

The human striatum has structural and functional subdivisions, both dorsoventrally and rostrocaudally. To date, the gradients of dopamine D2/3 receptor binding in the human striatum have not been measured with positron emission tomography (PET). Seven healthy male subjects aged 24.5 ± 3.5 years were scanned with brain-dedicated high-resolution research tomography (HRRT, Siemens Medical Solutions, Knoxville, TN, USA) and [(11)C]raclopride. Coronally defined regions of interest (ROIs) of the caudate nucleus, putamen and ventral striatum (VST) were sampled plane-by-plane, 1.5mm apart, on spatially normalized binding potential (BPND) images. Regional [(11)C]raclopride BPND values were calculated using the simplified reference tissue model (SRTM) from a total of 25 coronal planes. An increasing rostrocaudal gradient of the D2/3 receptor binding was detected in the putamen, which is consistent with the known distribution of D2/3 dopamine receptors. In the caudate nucleus, there was an initial increase in the BPND values in the most anterior planes, suggesting that the highest D2/3 receptor binding occurred in the head; however, there was an overall descending gradient. A declining trend was also observed in the VST. The novelty of this study lies in the presentation, for the first time, of the D2/3 receptor binding gradients in each striatal subregion in the brains of living healthy humans. The high spatial resolution provided by HRRT enables frequent sampling of BPND along the longitudinal extent of striatum; this method is superior to the sectioning used in previous post mortem studies. Regarding the functional organization of the striatum, our findings can inform future investigations of normal neurophysiology as well as efforts to differentiate neuropsychiatric disorders affecting the brain dopamine (DA) system. Furthermore, the average distribution of D2/3 receptor binding revealed in this study could serve as a basis for a database that includes distributions of various DA markers as a function of healthy aging.

Authors+Show Affiliations

Turku PET Centre, University of Turku and Turku University Hospital, PO Box 52, FIN-20521 Turku, Finland. khalak@utu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23727314

Citation

Alakurtti, Kati, et al. "Rostrocaudal Gradients of Dopamine D2/3 Receptor Binding in Striatal Subregions Measured With [(11)C]raclopride and High-resolution Positron Emission Tomography." NeuroImage, vol. 82, 2013, pp. 252-9.
Alakurtti K, Johansson JJ, Tuokkola T, et al. Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography. Neuroimage. 2013;82:252-9.
Alakurtti, K., Johansson, J. J., Tuokkola, T., Någren, K., & Rinne, J. O. (2013). Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography. NeuroImage, 82, 252-9. https://doi.org/10.1016/j.neuroimage.2013.05.091
Alakurtti K, et al. Rostrocaudal Gradients of Dopamine D2/3 Receptor Binding in Striatal Subregions Measured With [(11)C]raclopride and High-resolution Positron Emission Tomography. Neuroimage. 2013 Nov 15;82:252-9. PubMed PMID: 23727314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography. AU - Alakurtti,Kati, AU - Johansson,Jarkko J, AU - Tuokkola,Terhi, AU - Någren,Kjell, AU - Rinne,Juha O, Y1 - 2013/05/28/ PY - 2013/03/05/received PY - 2013/05/10/revised PY - 2013/05/16/accepted PY - 2013/6/4/entrez PY - 2013/6/4/pubmed PY - 2014/4/16/medline KW - AC KW - AP KW - BP(ND) KW - D(2/3) receptors KW - DA KW - DAT KW - DCA KW - DPU KW - Dopamine KW - Gradient KW - HRRT KW - MSA KW - PET KW - PSP KW - PVE KW - ROI KW - SRTM KW - TAC KW - VST KW - Ventral striatum KW - [(11)C]raclopride KW - anterior commissure KW - anterior–posterior KW - dopamine KW - dopamine transporter KW - dorsal caudate nucleus KW - dorsal putamen KW - high-resolution research tomography KW - multiple system atrophy KW - non-displaceable binding potential KW - partial volume effect KW - positron emission tomography KW - progressive supranuclear palsy KW - region of interest KW - simplified reference tissue model KW - time–activity curve KW - ventral striatum SP - 252 EP - 9 JF - NeuroImage JO - Neuroimage VL - 82 N2 - The human striatum has structural and functional subdivisions, both dorsoventrally and rostrocaudally. To date, the gradients of dopamine D2/3 receptor binding in the human striatum have not been measured with positron emission tomography (PET). Seven healthy male subjects aged 24.5 ± 3.5 years were scanned with brain-dedicated high-resolution research tomography (HRRT, Siemens Medical Solutions, Knoxville, TN, USA) and [(11)C]raclopride. Coronally defined regions of interest (ROIs) of the caudate nucleus, putamen and ventral striatum (VST) were sampled plane-by-plane, 1.5mm apart, on spatially normalized binding potential (BPND) images. Regional [(11)C]raclopride BPND values were calculated using the simplified reference tissue model (SRTM) from a total of 25 coronal planes. An increasing rostrocaudal gradient of the D2/3 receptor binding was detected in the putamen, which is consistent with the known distribution of D2/3 dopamine receptors. In the caudate nucleus, there was an initial increase in the BPND values in the most anterior planes, suggesting that the highest D2/3 receptor binding occurred in the head; however, there was an overall descending gradient. A declining trend was also observed in the VST. The novelty of this study lies in the presentation, for the first time, of the D2/3 receptor binding gradients in each striatal subregion in the brains of living healthy humans. The high spatial resolution provided by HRRT enables frequent sampling of BPND along the longitudinal extent of striatum; this method is superior to the sectioning used in previous post mortem studies. Regarding the functional organization of the striatum, our findings can inform future investigations of normal neurophysiology as well as efforts to differentiate neuropsychiatric disorders affecting the brain dopamine (DA) system. Furthermore, the average distribution of D2/3 receptor binding revealed in this study could serve as a basis for a database that includes distributions of various DA markers as a function of healthy aging. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/23727314/Rostrocaudal_gradients_of_dopamine_D2/3_receptor_binding_in_striatal_subregions_measured_with_[_11_C]raclopride_and_high_resolution_positron_emission_tomography_ DB - PRIME DP - Unbound Medicine ER -