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The association between vitamin D and cognition: a systematic review.
Ageing Res Rev. 2013 Sep; 12(4):1013-23.AR

Abstract

Vitamin D insufficiency and deficiency are a major health care problem. The association between vitamin D levels and cognitive function is still under debate. We conducted a systematic review to assess the association between levels of vitamin D and cognition. Therefore, the databases of Embase and Pubmed were searched through June 2012 for observational studies relating vitamin D levels to cognition. Our initial search yielded 2182 articles. After applying exclusion criteria, there were 28 studies eligible for inclusion: 25 cross-sectional and 6 prospective studies (3 studies show cross-sectional as well as prospective data). The main finding of the 25 cross-sectional studies was a statistically significant worse outcome on one or more cognitive function tests or a higher frequency of dementia with lower vitamin D levels or intake in 18 out of 25 (72%) studies, whereas 7 (28%) studies failed to show an association. Four out of 6 (66.7%) prospective studies showed a higher risk of cognitive decline after a follow-up period of 4-7 years in participants with lower vitamin D levels at baseline. In conclusion, this review supports the hypothesis that hypovitaminosis D is associated with worse outcome on one or more cognitive function tests or a higher frequency of dementia in cross-sectional as well as prospective studies. Further studies should focus on the role of vitamin D supplementation in the prevention of cognitive decline in participants with low vitamin D levels.

Authors+Show Affiliations

Department of Geriatrics, University Medical Center Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

23727408

Citation

van der Schaft, J, et al. "The Association Between Vitamin D and Cognition: a Systematic Review." Ageing Research Reviews, vol. 12, no. 4, 2013, pp. 1013-23.
van der Schaft J, Koek HL, Dijkstra E, et al. The association between vitamin D and cognition: a systematic review. Ageing Res Rev. 2013;12(4):1013-23.
van der Schaft, J., Koek, H. L., Dijkstra, E., Verhaar, H. J., van der Schouw, Y. T., & Emmelot-Vonk, M. H. (2013). The association between vitamin D and cognition: a systematic review. Ageing Research Reviews, 12(4), 1013-23. https://doi.org/10.1016/j.arr.2013.05.004
van der Schaft J, et al. The Association Between Vitamin D and Cognition: a Systematic Review. Ageing Res Rev. 2013;12(4):1013-23. PubMed PMID: 23727408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between vitamin D and cognition: a systematic review. AU - van der Schaft,J, AU - Koek,H L, AU - Dijkstra,E, AU - Verhaar,H J J, AU - van der Schouw,Y T, AU - Emmelot-Vonk,M H, Y1 - 2013/05/29/ PY - 2013/03/12/received PY - 2013/05/18/revised PY - 2013/05/22/accepted PY - 2013/6/4/entrez PY - 2013/6/4/pubmed PY - 2014/8/13/medline KW - Cognition KW - Deficiency KW - Systematic review KW - Vitamin D SP - 1013 EP - 23 JF - Ageing research reviews JO - Ageing Res Rev VL - 12 IS - 4 N2 - Vitamin D insufficiency and deficiency are a major health care problem. The association between vitamin D levels and cognitive function is still under debate. We conducted a systematic review to assess the association between levels of vitamin D and cognition. Therefore, the databases of Embase and Pubmed were searched through June 2012 for observational studies relating vitamin D levels to cognition. Our initial search yielded 2182 articles. After applying exclusion criteria, there were 28 studies eligible for inclusion: 25 cross-sectional and 6 prospective studies (3 studies show cross-sectional as well as prospective data). The main finding of the 25 cross-sectional studies was a statistically significant worse outcome on one or more cognitive function tests or a higher frequency of dementia with lower vitamin D levels or intake in 18 out of 25 (72%) studies, whereas 7 (28%) studies failed to show an association. Four out of 6 (66.7%) prospective studies showed a higher risk of cognitive decline after a follow-up period of 4-7 years in participants with lower vitamin D levels at baseline. In conclusion, this review supports the hypothesis that hypovitaminosis D is associated with worse outcome on one or more cognitive function tests or a higher frequency of dementia in cross-sectional as well as prospective studies. Further studies should focus on the role of vitamin D supplementation in the prevention of cognitive decline in participants with low vitamin D levels. SN - 1872-9649 UR - https://www.unboundmedicine.com/medline/citation/23727408/The_association_between_vitamin_D_and_cognition:_a_systematic_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-1637(13)00026-3 DB - PRIME DP - Unbound Medicine ER -