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Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study.
Occup Environ Med. 2013 Sep; 70(9):648-55.OE

Abstract

AIM

In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures.

METHODS

All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure.

RESULTS

683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.7) and mineral oils (OR 1.4)[corrected]. Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2).

CONCLUSIONS

We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.

Authors+Show Affiliations

Occupational and Environmental Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Florence, Italy. l.miligi@ispo.toscana.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23729503

Citation

Miligi, Lucia, et al. "Risk of Childhood Leukaemia and non-Hodgkin's Lymphoma After Parental Occupational Exposure to Solvents and Other Agents: the SETIL Study." Occupational and Environmental Medicine, vol. 70, no. 9, 2013, pp. 648-55.
Miligi L, Benvenuti A, Mattioli S, et al. Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study. Occup Environ Med. 2013;70(9):648-55.
Miligi, L., Benvenuti, A., Mattioli, S., Salvan, A., Tozzi, G. A., Ranucci, A., Legittimo, P., Rondelli, R., Bisanti, L., Zambon, P., Cannizzaro, S., Kirchmayer, U., Cocco, P., Celentano, E., Assennato, G., Merlo, D. F., Mosciatti, P., Minelli, L., Cuttini, M., ... Magnani, C. (2013). Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study. Occupational and Environmental Medicine, 70(9), 648-55. https://doi.org/10.1136/oemed-2012-100951
Miligi L, et al. Risk of Childhood Leukaemia and non-Hodgkin's Lymphoma After Parental Occupational Exposure to Solvents and Other Agents: the SETIL Study. Occup Environ Med. 2013;70(9):648-55. PubMed PMID: 23729503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study. AU - Miligi,Lucia, AU - Benvenuti,Alessandra, AU - Mattioli,Stefano, AU - Salvan,Alberto, AU - Tozzi,Giulio Andrea, AU - Ranucci,Alessandra, AU - Legittimo,Patrizia, AU - Rondelli,Roberto, AU - Bisanti,Luigi, AU - Zambon,Paola, AU - Cannizzaro,Santina, AU - Kirchmayer,Ursula, AU - Cocco,Pierluigi, AU - Celentano,Egidio, AU - Assennato,Giorgio, AU - Merlo,Domenico Franco, AU - Mosciatti,Paola, AU - Minelli,Liliana, AU - Cuttini,Marina, AU - Torregrossa,Valeria, AU - Lagorio,Susanna, AU - Haupt,Riccardo, AU - Risica,Serena, AU - Polichetti,Alessandro, AU - ,, AU - Magnani,Corrado, Y1 - 2013/06/01/ PY - 2013/6/5/entrez PY - 2013/6/5/pubmed PY - 2013/10/30/medline SP - 648 EP - 55 JF - Occupational and environmental medicine JO - Occup Environ Med VL - 70 IS - 9 N2 - AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. RESULTS: 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.7) and mineral oils (OR 1.4)[corrected]. Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). CONCLUSIONS: We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts. SN - 1470-7926 UR - https://www.unboundmedicine.com/medline/citation/23729503/Risk_of_childhood_leukaemia_and_non_Hodgkin's_lymphoma_after_parental_occupational_exposure_to_solvents_and_other_agents:_the_SETIL_Study_ L2 - https://oem.bmj.com/lookup/pmidlookup?view=long&pmid=23729503 DB - PRIME DP - Unbound Medicine ER -