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Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial.
J Nutr Health Aging. 2013; 17(6):544-52.JN

Abstract

OBJECTIVE

To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet).

DESIGN

Randomized trial after 6.5 years of nutritional intervention.

SETTING

Eight primary care centers affiliated to the University of Navarra.

PARTICIPANTS

A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation).

INTERVENTIONS

Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter.

MEASUREMENTS

Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention.

RESULTS

Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls.

CONCLUSION

A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.

Authors+Show Affiliations

Departamento de Medicina Preventiva y Salud Pública, Facultad de Medicina-Clínica Universidad de Navarra, Universidad de Navarra, C/ Irunlarrea n1 1, Pamplona, Navarra, E-31008, Spain. elenahmlapiscina@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

23732551

Citation

Martínez-Lapiscina, E H., et al. "Virgin Olive Oil Supplementation and Long-term Cognition: the PREDIMED-NAVARRA Randomized, Trial." The Journal of Nutrition, Health & Aging, vol. 17, no. 6, 2013, pp. 544-52.
Martínez-Lapiscina EH, Clavero P, Toledo E, et al. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J Nutr Health Aging. 2013;17(6):544-52.
Martínez-Lapiscina, E. H., Clavero, P., Toledo, E., San Julián, B., Sanchez-Tainta, A., Corella, D., Lamuela-Raventós, R. M., Martínez, J. A., & Martínez-Gonzalez, M. Á. (2013). Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. The Journal of Nutrition, Health & Aging, 17(6), 544-52. https://doi.org/10.1007/s12603-013-0027-6
Martínez-Lapiscina EH, et al. Virgin Olive Oil Supplementation and Long-term Cognition: the PREDIMED-NAVARRA Randomized, Trial. J Nutr Health Aging. 2013;17(6):544-52. PubMed PMID: 23732551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. AU - Martínez-Lapiscina,E H, AU - Clavero,P, AU - Toledo,E, AU - San Julián,B, AU - Sanchez-Tainta,A, AU - Corella,D, AU - Lamuela-Raventós,R M, AU - Martínez,J A, AU - Martínez-Gonzalez,M Á, PY - 2013/6/5/entrez PY - 2013/6/5/pubmed PY - 2014/1/29/medline SP - 544 EP - 52 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 17 IS - 6 N2 - OBJECTIVE: To assess the effect on cognition of a controlled intervention testing Mediterranean diets (MedDiet). DESIGN: Randomized trial after 6.5 years of nutritional intervention. SETTING: Eight primary care centers affiliated to the University of Navarra. PARTICIPANTS: A random subsample of 285 participants (95 randomly allocated to each of 3 groups) of the PREDIMED-NAVARRA trial. All of them were at high vascular risk (44.8% men, 74.1±5.7 years at cognitive evaluation). INTERVENTIONS: Nutritional intervention comparing two MedDiets (supplemented with extra-virgin olive oil [EVOO] or mixed nuts) versus a low-fat control diet. Participants received intensive education to increase adherence to the intended intervention. Participants allocated to the MedDiet groups received EVOO (1 l/week) or 30 g/day of mixed nuts. Dietary habits were evaluated using a validated 137-item food frequency questionnaire (FFQ). Additionally, adherence to MedDiet was appraised using a 14-item questionnaire both at baseline and yearly thereafter. MEASUREMENTS: Cognitive performance as a main outcome and cognitive status (normal, mild cognitive impairment [MCI] or dementia) as a secondary outcome were evaluated by two neurologists blinded to group assignment after 6.5 years of nutritional intervention. RESULTS: Better post-trial cognitive performance versus control in all cognitive domains and significantly better performance across fluency and memory tasks were observed for participants allocated to the MedDiet+EVOO group. After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group also showed lower MCI (OR=0.34 95% CI: 0.12-0.97) compared with control group. Participants assigned to MedDiet+Nuts group did not differ from controls. CONCLUSION: A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/23732551/Virgin_olive_oil_supplementation_and_long_term_cognition:_the_PREDIMED_NAVARRA_randomized_trial_ L2 - https://ClinicalTrials.gov/search/term=23732551 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -