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Self- or parent report of (co-occurring) internalizing and externalizing problems, and basal or reactivity measures of HPA-axis functioning: a systematic evaluation of the internalizing-hyperresponsivity versus externalizing-hyporesponsivity HPA-axis hypothesis.
Biol Psychol. 2013 Sep; 94(1):175-84.BP

Abstract

BACKGROUND

Previous research findings on the link between adolescents' psychopathology and hypothalamic-pituitary-adrenal (HPA) axis activity have been heterogeneous.

METHOD

Adolescents (n=211) with a preadolescent DSM-IV diagnosis participated in a lab-based social stress task. Saliva cortisol was assessed at awakening and during social stress. It was investigated if continuous measures of internalizing and externalizing problems and their interaction, using both self- and parent report, were associated with basal or reactivity measures of HPA-axis functioning.

RESULTS

During social stress, an enhanced total release of cortisol was associated with self-reported internalizing problems and a blunted total release of cortisol with self-reported externalizing problems. Post hoc analyses revealed that the association between enhanced cortisol output and internalizing problems held for boys but not for girls. Associations with morning cortisol measures were overall weak.

CONCLUSIONS

Only in the context of stress, and particularly when based on self-report, blunted cortisol output was associated with externalizing and enhanced cortisol output with internalizing problems. Our broad approach demonstrates the importance of who reports on psychopathology, the use of dimensional measures of psychopathology, simultaneous analysis of internalizing and externalizing problems, and the use of awakening and social stress related measures of cortisol.

Authors+Show Affiliations

Interdisciplinary Center for Psychiatric Epidemiology, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. c.hartman@accare.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23735709

Citation

Hartman, Catharina A., et al. "Self- or Parent Report of (co-occurring) Internalizing and Externalizing Problems, and Basal or Reactivity Measures of HPA-axis Functioning: a Systematic Evaluation of the Internalizing-hyperresponsivity Versus Externalizing-hyporesponsivity HPA-axis Hypothesis." Biological Psychology, vol. 94, no. 1, 2013, pp. 175-84.
Hartman CA, Hermanns VW, de Jong PJ, et al. Self- or parent report of (co-occurring) internalizing and externalizing problems, and basal or reactivity measures of HPA-axis functioning: a systematic evaluation of the internalizing-hyperresponsivity versus externalizing-hyporesponsivity HPA-axis hypothesis. Biol Psychol. 2013;94(1):175-84.
Hartman, C. A., Hermanns, V. W., de Jong, P. J., & Ormel, J. (2013). Self- or parent report of (co-occurring) internalizing and externalizing problems, and basal or reactivity measures of HPA-axis functioning: a systematic evaluation of the internalizing-hyperresponsivity versus externalizing-hyporesponsivity HPA-axis hypothesis. Biological Psychology, 94(1), 175-84. https://doi.org/10.1016/j.biopsycho.2013.05.009
Hartman CA, et al. Self- or Parent Report of (co-occurring) Internalizing and Externalizing Problems, and Basal or Reactivity Measures of HPA-axis Functioning: a Systematic Evaluation of the Internalizing-hyperresponsivity Versus Externalizing-hyporesponsivity HPA-axis Hypothesis. Biol Psychol. 2013;94(1):175-84. PubMed PMID: 23735709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self- or parent report of (co-occurring) internalizing and externalizing problems, and basal or reactivity measures of HPA-axis functioning: a systematic evaluation of the internalizing-hyperresponsivity versus externalizing-hyporesponsivity HPA-axis hypothesis. AU - Hartman,Catharina A, AU - Hermanns,Vera W, AU - de Jong,Peter J, AU - Ormel,Johan, Y1 - 2013/06/02/ PY - 2012/04/07/received PY - 2013/04/28/revised PY - 2013/05/14/accepted PY - 2013/6/6/entrez PY - 2013/6/6/pubmed PY - 2013/10/30/medline KW - AUC KW - Adolescents KW - CAR KW - CBCL KW - CD KW - Child Behavior Checklist KW - Cortisol KW - EXT KW - Externalizing problems KW - GSST KW - Groningen Social Stress Test KW - INT KW - Internalizing problems KW - OCC KW - ODD KW - Psychopathology KW - YSR KW - Youth Self Report KW - area under the curve KW - conduct disorder KW - cortisol awakening response KW - externalizing problems KW - internalizing problems KW - oppositional defiant disorder KW - oral contraceptives SP - 175 EP - 84 JF - Biological psychology JO - Biol Psychol VL - 94 IS - 1 N2 - BACKGROUND: Previous research findings on the link between adolescents' psychopathology and hypothalamic-pituitary-adrenal (HPA) axis activity have been heterogeneous. METHOD: Adolescents (n=211) with a preadolescent DSM-IV diagnosis participated in a lab-based social stress task. Saliva cortisol was assessed at awakening and during social stress. It was investigated if continuous measures of internalizing and externalizing problems and their interaction, using both self- and parent report, were associated with basal or reactivity measures of HPA-axis functioning. RESULTS: During social stress, an enhanced total release of cortisol was associated with self-reported internalizing problems and a blunted total release of cortisol with self-reported externalizing problems. Post hoc analyses revealed that the association between enhanced cortisol output and internalizing problems held for boys but not for girls. Associations with morning cortisol measures were overall weak. CONCLUSIONS: Only in the context of stress, and particularly when based on self-report, blunted cortisol output was associated with externalizing and enhanced cortisol output with internalizing problems. Our broad approach demonstrates the importance of who reports on psychopathology, the use of dimensional measures of psychopathology, simultaneous analysis of internalizing and externalizing problems, and the use of awakening and social stress related measures of cortisol. SN - 1873-6246 UR - https://www.unboundmedicine.com/medline/citation/23735709/Self__or_parent_report_of__co_occurring__internalizing_and_externalizing_problems_and_basal_or_reactivity_measures_of_HPA_axis_functioning:_a_systematic_evaluation_of_the_internalizing_hyperresponsivity_versus_externalizing_hyporesponsivity_HPA_axis_hypothesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(13)00127-0 DB - PRIME DP - Unbound Medicine ER -