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Composition and in vitro anticancer activities of the leaf essential oil of Neolitsea variabillima from Taiwan.
Nat Prod Commun. 2013 Apr; 8(4):531-2.NP

Abstract

This study investigated the chemical composition and in vitro anticancer activities of the essential oil isolated from the leaf of Neolitsea variabillima. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Sixty-seven compounds were identified, representing 100% of the oil. The main components identified were trans-beta-ocimene (13.4%), alpha-cadinol (10.5%), terpinen-4-ol (9.3%), tau-cadinol (9.2%), beta-caryophyllene (8.8%), and sabinene (6.7%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The presence of beta-caryophyllene, tau-cadinol, and alpha-cadinol significantly contributed to the anticancer activities of N. variabillima leaf oil.

Authors+Show Affiliations

Su YC
Department of Forestry, National Chung Hsing University, 250 Kuo Kuang Rd., Taichung, Taiwan 402.
Hsu KP
No affiliation info available
Wang EI
No affiliation info available
Ho CL
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicCell Line, TumorHumansLauraceaeOils, VolatilePlant LeavesTaiwan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23738472

Citation

Su, Yu-Chang, et al. "Composition and in Vitro Anticancer Activities of the Leaf Essential Oil of Neolitsea Variabillima From Taiwan." Natural Product Communications, vol. 8, no. 4, 2013, pp. 531-2.
Su YC, Hsu KP, Wang EI, et al. Composition and in vitro anticancer activities of the leaf essential oil of Neolitsea variabillima from Taiwan. Nat Prod Commun. 2013;8(4):531-2.
Su, Y. C., Hsu, K. P., Wang, E. I., & Ho, C. L. (2013). Composition and in vitro anticancer activities of the leaf essential oil of Neolitsea variabillima from Taiwan. Natural Product Communications, 8(4), 531-2.
Su YC, et al. Composition and in Vitro Anticancer Activities of the Leaf Essential Oil of Neolitsea Variabillima From Taiwan. Nat Prod Commun. 2013;8(4):531-2. PubMed PMID: 23738472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition and in vitro anticancer activities of the leaf essential oil of Neolitsea variabillima from Taiwan. AU - Su,Yu-Chang, AU - Hsu,Kuan-Ping, AU - Wang,Eugene I-Chen, AU - Ho,Chen-Lung, PY - 2013/6/7/entrez PY - 2013/6/7/pubmed PY - 2013/8/13/medline SP - 531 EP - 2 JF - Natural product communications JO - Nat Prod Commun VL - 8 IS - 4 N2 - This study investigated the chemical composition and in vitro anticancer activities of the essential oil isolated from the leaf of Neolitsea variabillima. The essential oil was isolated using hydrodistillation in a Clevenger-type apparatus, and characterized by GC-FID and GC-MS. Sixty-seven compounds were identified, representing 100% of the oil. The main components identified were trans-beta-ocimene (13.4%), alpha-cadinol (10.5%), terpinen-4-ol (9.3%), tau-cadinol (9.2%), beta-caryophyllene (8.8%), and sabinene (6.7%). The anticancer activities of oil were evaluated. The results showed that the oil exhibited cytotoxic activity against human oral, liver, lung, colon, melanoma, and leukemic cancer cells. The presence of beta-caryophyllene, tau-cadinol, and alpha-cadinol significantly contributed to the anticancer activities of N. variabillima leaf oil. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/23738472/Composition_and_in_vitro_anticancer_activities_of_the_leaf_essential_oil_of_Neolitsea_variabillima_from_Taiwan_ DB - PRIME DP - Unbound Medicine ER -