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Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media.
J Infect Dis. 1990 Aug; 162(2):546-9.JI

Abstract

Fifty-eight infants and children with acute otitis media were prospectively studied for bacterial and viral pathogenesis and response to antibiotic therapy. Tympanocentesis for bacterial and viral cultures of middle ear fluids (MEF) was done before and 2-4 days after beginning treatment. Patients were followed until the end of antibiotic course. Bacteria were cultured from the preantibiotic MEF in 43 cases (74%). Viruses were cultured from the preantibiotic MEF in 11 cases (19%); all of these MEFs also contained bacterial pathogens. A significantly higher proportion of patients with both virus and bacteria (50%) failed to respond with clearing of bacteria 2-4 days into therapy compared with the group with bacteria alone (13%). The patients with persistently positive viral cultures of the MEF seemed to have purulent otitis of longer duration. Presence of virus in the MEF may interfere with bacteriologic and clinical responses to antibiotic. The mechanism of interference deserves further investigation.

Authors+Show Affiliations

Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2373879

Citation

Chonmaitree, T, et al. "Respiratory Viruses Interfere With Bacteriologic Response to Antibiotic in Children With Acute Otitis Media." The Journal of Infectious Diseases, vol. 162, no. 2, 1990, pp. 546-9.
Chonmaitree T, Owen MJ, Howie VM. Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media. J Infect Dis. 1990;162(2):546-9.
Chonmaitree, T., Owen, M. J., & Howie, V. M. (1990). Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media. The Journal of Infectious Diseases, 162(2), 546-9.
Chonmaitree T, Owen MJ, Howie VM. Respiratory Viruses Interfere With Bacteriologic Response to Antibiotic in Children With Acute Otitis Media. J Infect Dis. 1990;162(2):546-9. PubMed PMID: 2373879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media. AU - Chonmaitree,T, AU - Owen,M J, AU - Howie,V M, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 546 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 162 IS - 2 N2 - Fifty-eight infants and children with acute otitis media were prospectively studied for bacterial and viral pathogenesis and response to antibiotic therapy. Tympanocentesis for bacterial and viral cultures of middle ear fluids (MEF) was done before and 2-4 days after beginning treatment. Patients were followed until the end of antibiotic course. Bacteria were cultured from the preantibiotic MEF in 43 cases (74%). Viruses were cultured from the preantibiotic MEF in 11 cases (19%); all of these MEFs also contained bacterial pathogens. A significantly higher proportion of patients with both virus and bacteria (50%) failed to respond with clearing of bacteria 2-4 days into therapy compared with the group with bacteria alone (13%). The patients with persistently positive viral cultures of the MEF seemed to have purulent otitis of longer duration. Presence of virus in the MEF may interfere with bacteriologic and clinical responses to antibiotic. The mechanism of interference deserves further investigation. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/2373879/Respiratory_viruses_interfere_with_bacteriologic_response_to_antibiotic_in_children_with_acute_otitis_media_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/162.2.546 DB - PRIME DP - Unbound Medicine ER -