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Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study.

Abstract

Fruits and vegetables have been examined for their possible effects on the risk of bladder cancer, as they contain numerous nutrients, phytochemicals, and antioxidants with potentially anticarcinogenic properties. In a prospective analysis of 185,885 older adults participating in the Multiethnic Cohort Study, we examined whether the consumption of fruits and vegetables, or of nutrients concentrated in fruits and vegetables, was associated with bladder cancer risk. Cox proportional hazards models were used to calculate HRs and 95% CIs for bladder cancer in relation to dietary intakes. A total of 581 invasive bladder cancer cases (429 men and 152 women) were diagnosed over a mean follow-up period of 12.5 y. In women, total fruits and vegetables [HR = 0.35 (95% CI: 0.22, 0.56); highest vs. lowest quartile], total vegetables [HR = 0.49 (95% CI: 0.29, 0.83)], yellow-orange vegetables [HR = 0.48 (95% CI: 0.30, 0.77)], total fruits [HR = 0.54 (95% CI: 0.34, 0.85)], and citrus fruits [HR = 0.56 (95% CI: 0.34, 0.90)] were inversely associated with the risk of invasive bladder cancer in risk factor-adjusted models. In addition, women with the highest intakes of vitamins A, C, and E; the carotenoids α-carotene, β-carotene, and β-cryptoxanthin; and folate had a lower risk of bladder cancer. For men, no associations for fruits, vegetables, or nutrients were found overall, although inverse associations were observed for vegetable intake among current smokers, and in ethnic-specific analyses, for fruit and vegetable intake among Latinos specifically. Our findings suggest that greater consumption of fruits and vegetables may lower the risk of invasive bladder cancer among women and highlight the need for specific subgroup analyses in future studies.

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  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA. spark@cc.hawaii.edu

    , , , ,

    Source

    The Journal of nutrition 143:8 2013 Aug pg 1283-92

    MeSH

    Aged
    Antioxidants
    Carotenoids
    Cohort Studies
    Cryptoxanthins
    Ethnic Groups
    Feeding Behavior
    Female
    Folic Acid
    Follow-Up Studies
    Fruit
    Humans
    Male
    Middle Aged
    Nutrition Assessment
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Urinary Bladder Neoplasms
    Vegetables
    Vitamin E
    Xanthophylls
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    23739308

    Citation

    Park, Song-Yi, et al. "Fruit and Vegetable Intakes Are Associated With Lower Risk of Bladder Cancer Among Women in the Multiethnic Cohort Study." The Journal of Nutrition, vol. 143, no. 8, 2013, pp. 1283-92.
    Park SY, Ollberding NJ, Woolcott CG, et al. Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study. J Nutr. 2013;143(8):1283-92.
    Park, S. Y., Ollberding, N. J., Woolcott, C. G., Wilkens, L. R., Henderson, B. E., & Kolonel, L. N. (2013). Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study. The Journal of Nutrition, 143(8), pp. 1283-92. doi:10.3945/jn.113.174920.
    Park SY, et al. Fruit and Vegetable Intakes Are Associated With Lower Risk of Bladder Cancer Among Women in the Multiethnic Cohort Study. J Nutr. 2013;143(8):1283-92. PubMed PMID: 23739308.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable intakes are associated with lower risk of bladder cancer among women in the Multiethnic Cohort Study. AU - Park,Song-Yi, AU - Ollberding,Nicholas J, AU - Woolcott,Christy G, AU - Wilkens,Lynne R, AU - Henderson,Brian E, AU - Kolonel,Laurence N, Y1 - 2013/06/05/ PY - 2013/6/7/entrez PY - 2013/6/7/pubmed PY - 2013/9/24/medline SP - 1283 EP - 92 JF - The Journal of nutrition JO - J. Nutr. VL - 143 IS - 8 N2 - Fruits and vegetables have been examined for their possible effects on the risk of bladder cancer, as they contain numerous nutrients, phytochemicals, and antioxidants with potentially anticarcinogenic properties. In a prospective analysis of 185,885 older adults participating in the Multiethnic Cohort Study, we examined whether the consumption of fruits and vegetables, or of nutrients concentrated in fruits and vegetables, was associated with bladder cancer risk. Cox proportional hazards models were used to calculate HRs and 95% CIs for bladder cancer in relation to dietary intakes. A total of 581 invasive bladder cancer cases (429 men and 152 women) were diagnosed over a mean follow-up period of 12.5 y. In women, total fruits and vegetables [HR = 0.35 (95% CI: 0.22, 0.56); highest vs. lowest quartile], total vegetables [HR = 0.49 (95% CI: 0.29, 0.83)], yellow-orange vegetables [HR = 0.48 (95% CI: 0.30, 0.77)], total fruits [HR = 0.54 (95% CI: 0.34, 0.85)], and citrus fruits [HR = 0.56 (95% CI: 0.34, 0.90)] were inversely associated with the risk of invasive bladder cancer in risk factor-adjusted models. In addition, women with the highest intakes of vitamins A, C, and E; the carotenoids α-carotene, β-carotene, and β-cryptoxanthin; and folate had a lower risk of bladder cancer. For men, no associations for fruits, vegetables, or nutrients were found overall, although inverse associations were observed for vegetable intake among current smokers, and in ethnic-specific analyses, for fruit and vegetable intake among Latinos specifically. Our findings suggest that greater consumption of fruits and vegetables may lower the risk of invasive bladder cancer among women and highlight the need for specific subgroup analyses in future studies. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/23739308/Fruit_and_vegetable_intakes_are_associated_with_lower_risk_of_bladder_cancer_among_women_in_the_Multiethnic_Cohort_Study_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.174920 DB - PRIME DP - Unbound Medicine ER -