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Impaired plasma cholesteryl ester transfer with accumulation of larger high density lipoproteins in some families of baboons (Papio sp.).
J Lipid Res. 1990 Jun; 31(6):965-73.JL

Abstract

Baboons from some families have a higher concentration of plasma high density lipoproteins (HDL) on a chow diet and accumulate large HDL (HDL1) when challenged with a high cholesterol and high saturated fat (HCHF) diet. HDL1 from high HDL1 animals contained more (1.5-fold) cholesteryl ester than HDL (HDL2 + HDL3) from high or low HDL1 animals. HDL from high HDL1 baboons had lower triglyceride content than that from low HDL1 baboons. HDL3 or HDL labeled with [3H]cholesteryl linoleate was incubated with entire lipoprotein fraction (d less than 1.21 g/ml) or very low density lipoprotein + low density lipoprotein (VLDL + LDL) (d less than 1.045 g/ml) and with lipoprotein-deficient serum (LPDS), and the radioactive cholesteryl ester and mass floating at d 1.045 g/ml (VLDL + LDL) after the incubation was measured. The transfer of cholesteryl esters from either HDL or HDL3, prepared from plasma of high HDL1 animals fed chow or the HCHF diet, was slower than the transfer from either HDL or HDL3 of low HDL1 animals, regardless of the source of transfer activity or the ratio of LDL:HDL-protein used in the assay. Addition of HDL from high HDL1 baboons into an assay mixture of plasma components from low HDL1 baboons decreased the transfer of cholesteryl ester radioactivity and mass from HDL to VLDL and LDL. In addition to HDL, a fraction of intermediate density lipoprotein (IDL) and denser HDL were also effective in inhibiting the transfer. These observations suggest that accumulation of HDL1 in high HDL1 baboons fed an HCHF diet is associated with a slower transfer of cholesteryl esters from HDL to LDL.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Physiology, Southwest Foundation for Biomedical Research, San Antonio, TX 78228.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2373964

Citation

Kushwaha, R S., et al. "Impaired Plasma Cholesteryl Ester Transfer With Accumulation of Larger High Density Lipoproteins in some Families of Baboons (Papio Sp.)." Journal of Lipid Research, vol. 31, no. 6, 1990, pp. 965-73.
Kushwaha RS, Rainwater DL, Williams MC, et al. Impaired plasma cholesteryl ester transfer with accumulation of larger high density lipoproteins in some families of baboons (Papio sp.). J Lipid Res. 1990;31(6):965-73.
Kushwaha, R. S., Rainwater, D. L., Williams, M. C., Getz, G. S., & McGill, H. C. (1990). Impaired plasma cholesteryl ester transfer with accumulation of larger high density lipoproteins in some families of baboons (Papio sp.). Journal of Lipid Research, 31(6), 965-73.
Kushwaha RS, et al. Impaired Plasma Cholesteryl Ester Transfer With Accumulation of Larger High Density Lipoproteins in some Families of Baboons (Papio Sp.). J Lipid Res. 1990;31(6):965-73. PubMed PMID: 2373964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired plasma cholesteryl ester transfer with accumulation of larger high density lipoproteins in some families of baboons (Papio sp.). AU - Kushwaha,R S, AU - Rainwater,D L, AU - Williams,M C, AU - Getz,G S, AU - McGill,H C,Jr PY - 1990/6/1/pubmed PY - 2001/3/28/medline PY - 1990/6/1/entrez SP - 965 EP - 73 JF - Journal of lipid research JO - J. Lipid Res. VL - 31 IS - 6 N2 - Baboons from some families have a higher concentration of plasma high density lipoproteins (HDL) on a chow diet and accumulate large HDL (HDL1) when challenged with a high cholesterol and high saturated fat (HCHF) diet. HDL1 from high HDL1 animals contained more (1.5-fold) cholesteryl ester than HDL (HDL2 + HDL3) from high or low HDL1 animals. HDL from high HDL1 baboons had lower triglyceride content than that from low HDL1 baboons. HDL3 or HDL labeled with [3H]cholesteryl linoleate was incubated with entire lipoprotein fraction (d less than 1.21 g/ml) or very low density lipoprotein + low density lipoprotein (VLDL + LDL) (d less than 1.045 g/ml) and with lipoprotein-deficient serum (LPDS), and the radioactive cholesteryl ester and mass floating at d 1.045 g/ml (VLDL + LDL) after the incubation was measured. The transfer of cholesteryl esters from either HDL or HDL3, prepared from plasma of high HDL1 animals fed chow or the HCHF diet, was slower than the transfer from either HDL or HDL3 of low HDL1 animals, regardless of the source of transfer activity or the ratio of LDL:HDL-protein used in the assay. Addition of HDL from high HDL1 baboons into an assay mixture of plasma components from low HDL1 baboons decreased the transfer of cholesteryl ester radioactivity and mass from HDL to VLDL and LDL. In addition to HDL, a fraction of intermediate density lipoprotein (IDL) and denser HDL were also effective in inhibiting the transfer. These observations suggest that accumulation of HDL1 in high HDL1 baboons fed an HCHF diet is associated with a slower transfer of cholesteryl esters from HDL to LDL.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/2373964/Impaired_plasma_cholesteryl_ester_transfer_with_accumulation_of_larger_high_density_lipoproteins_in_some_families_of_baboons__Papio_sp___ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&pmid=2373964 DB - PRIME DP - Unbound Medicine ER -