Tags

Type your tag names separated by a space and hit enter

Left ventricular diastolic dysfunction by tissue Doppler echocardiography in pediatric chronic kidney disease.
Pediatr Nephrol. 2013 Oct; 28(10):2003-13.PN

Abstract

BACKGROUND

Myocardial dysfunction is common in chronic kidney disease (CKD) and related to poor outcomes. New non-invasive methods to assess cardiac function have been introduced, but comparative studies evaluating their clinical usefulness in pediatric CKD are lacking. We studied left ventricular (LV) function in pediatric CKD and renal transplant patients, comparing conventional pulse-wave Doppler echocardiography (cPWD) with newer tissue Doppler imaging (TDI) and relating the results to known cardiovascular risk factors.

METHODS

The study included 34 children/adolescents with CKD stages 2-5, 44 renal transplant patients and 19 patients with a normal renal function. The mean age was 11.4 (range 0.8-18.8) years.

RESULTS

Both patient groups had significantly lower LV diastolic function than those with a normal renal function. The most sensitive determinants were TDI E'/A' and cPWD E/TDI E' ratios. In a stepwise linear regression analysis, high blood pressure, young age and the presence of albuminuria all independently predicted LV diastolic function.

CONCLUSIONS

Our study confirms the high prevalence of LV diastolic dysfunction in pediatric CKD patients and following renal transplantation, where TDI appears to be more sensitive than cPWD in assessing early myocardial dysfunction. Our results also underline the importance of preventive measures, such as rigorous blood pressure control, in pediatric CKD.

Authors+Show Affiliations

Division of Pediatrics, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden. ylva.tranaeus-lindblad@karolinska.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23740035

Citation

Lindblad, Ylva Tranæus, et al. "Left Ventricular Diastolic Dysfunction By Tissue Doppler Echocardiography in Pediatric Chronic Kidney Disease." Pediatric Nephrology (Berlin, Germany), vol. 28, no. 10, 2013, pp. 2003-13.
Lindblad YT, Axelsson J, Balzano R, et al. Left ventricular diastolic dysfunction by tissue Doppler echocardiography in pediatric chronic kidney disease. Pediatr Nephrol. 2013;28(10):2003-13.
Lindblad, Y. T., Axelsson, J., Balzano, R., Vavilis, G., Chromek, M., Celsi, G., & Bárány, P. (2013). Left ventricular diastolic dysfunction by tissue Doppler echocardiography in pediatric chronic kidney disease. Pediatric Nephrology (Berlin, Germany), 28(10), 2003-13. https://doi.org/10.1007/s00467-013-2504-x
Lindblad YT, et al. Left Ventricular Diastolic Dysfunction By Tissue Doppler Echocardiography in Pediatric Chronic Kidney Disease. Pediatr Nephrol. 2013;28(10):2003-13. PubMed PMID: 23740035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Left ventricular diastolic dysfunction by tissue Doppler echocardiography in pediatric chronic kidney disease. AU - Lindblad,Ylva Tranæus, AU - Axelsson,Jonas, AU - Balzano,Rita, AU - Vavilis,Georgios, AU - Chromek,Milan, AU - Celsi,Gianni, AU - Bárány,Peter, Y1 - 2013/06/06/ PY - 2012/06/19/received PY - 2013/04/15/accepted PY - 2013/04/15/revised PY - 2013/6/7/entrez PY - 2013/6/7/pubmed PY - 2014/3/22/medline SP - 2003 EP - 13 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 28 IS - 10 N2 - BACKGROUND: Myocardial dysfunction is common in chronic kidney disease (CKD) and related to poor outcomes. New non-invasive methods to assess cardiac function have been introduced, but comparative studies evaluating their clinical usefulness in pediatric CKD are lacking. We studied left ventricular (LV) function in pediatric CKD and renal transplant patients, comparing conventional pulse-wave Doppler echocardiography (cPWD) with newer tissue Doppler imaging (TDI) and relating the results to known cardiovascular risk factors. METHODS: The study included 34 children/adolescents with CKD stages 2-5, 44 renal transplant patients and 19 patients with a normal renal function. The mean age was 11.4 (range 0.8-18.8) years. RESULTS: Both patient groups had significantly lower LV diastolic function than those with a normal renal function. The most sensitive determinants were TDI E'/A' and cPWD E/TDI E' ratios. In a stepwise linear regression analysis, high blood pressure, young age and the presence of albuminuria all independently predicted LV diastolic function. CONCLUSIONS: Our study confirms the high prevalence of LV diastolic dysfunction in pediatric CKD patients and following renal transplantation, where TDI appears to be more sensitive than cPWD in assessing early myocardial dysfunction. Our results also underline the importance of preventive measures, such as rigorous blood pressure control, in pediatric CKD. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/23740035/Left_ventricular_diastolic_dysfunction_by_tissue_Doppler_echocardiography_in_pediatric_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s00467-013-2504-x DB - PRIME DP - Unbound Medicine ER -