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MRI of the breast as part of the assessment in population-based mammography screening.
Rofo. 2013 Sep; 185(9):849-56.ROFO

Abstract

PURPOSE

To evaluate the indications and impact of MRI of the breast as an assessment modality in population-based mammography screening.

MATERIALS AND METHODS

135 consecutive contrast-enhanced MRI exams of the breast, which were performed between April 2007 and October 2012 as part of the assessment at one mammography screening unit before issuance of a final management recommendation (e. g. definitely benign or malignant), were retrospectively reviewed. Overall, the cases with an MRI exam of the breast during assessment represent less than 2 % of all assessment cases at this screening unit. All MRI exams were performed as part of the routine clinical care on a 1.5 T or 3 T whole-body magnet using a standard dynamic breast MRI protocol.

RESULTS

In the 135 study patients, a total of 30 malignancies in 28 patients were found, including two bilateral cancers. One patient was diagnosed with a non-Hodgkin lymphoma, and of the remaining 29 malignant lesions, 3 (10 %) were in-situ cancers (DCIS) and 26 (90 %) were invasive breast cancers including 3 multifocal or multicentric cancers. All 26 detected invasive cancers were lymph-node negative and 25/29 (86 %) of the detected breast cancer were early stage cancers (stage 0 or 1). 53 of the 135 MRI exams (39.3 %) were suspicious for malignancy (BIRADS 4 or 5) with no cancer missed by MRI. The sensitivity, specificity, positive predictive value, and negative predictive value of the MRI on a per patient basis were 100 %, 77 %, 0.53, and 1, respectively.

CONCLUSION

MRI is a useful problem-solving tool in mammography screening assessment with a high sensitivity and an acceptable positive predictive value.

Authors+Show Affiliations

Institut für Radiologie, Charité - Universitätsmedizin Berlin. Ulrich.Bick@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23740312

Citation

Bick, U, et al. "MRI of the Breast as Part of the Assessment in Population-based Mammography Screening." RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 185, no. 9, 2013, pp. 849-56.
Bick U, Engelken F, Diederichs G, et al. MRI of the breast as part of the assessment in population-based mammography screening. Rofo. 2013;185(9):849-56.
Bick, U., Engelken, F., Diederichs, G., Dzyuballa, R., Ortmann, M., & Fallenberg, E. M. (2013). MRI of the breast as part of the assessment in population-based mammography screening. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 185(9), 849-56. https://doi.org/10.1055/s-0033-1335518
Bick U, et al. MRI of the Breast as Part of the Assessment in Population-based Mammography Screening. Rofo. 2013;185(9):849-56. PubMed PMID: 23740312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI of the breast as part of the assessment in population-based mammography screening. AU - Bick,U, AU - Engelken,F, AU - Diederichs,G, AU - Dzyuballa,R, AU - Ortmann,M, AU - Fallenberg,E M, Y1 - 2013/06/05/ PY - 2013/6/7/entrez PY - 2013/6/7/pubmed PY - 2013/11/13/medline SP - 849 EP - 56 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 185 IS - 9 N2 - PURPOSE: To evaluate the indications and impact of MRI of the breast as an assessment modality in population-based mammography screening. MATERIALS AND METHODS: 135 consecutive contrast-enhanced MRI exams of the breast, which were performed between April 2007 and October 2012 as part of the assessment at one mammography screening unit before issuance of a final management recommendation (e. g. definitely benign or malignant), were retrospectively reviewed. Overall, the cases with an MRI exam of the breast during assessment represent less than 2 % of all assessment cases at this screening unit. All MRI exams were performed as part of the routine clinical care on a 1.5 T or 3 T whole-body magnet using a standard dynamic breast MRI protocol. RESULTS: In the 135 study patients, a total of 30 malignancies in 28 patients were found, including two bilateral cancers. One patient was diagnosed with a non-Hodgkin lymphoma, and of the remaining 29 malignant lesions, 3 (10 %) were in-situ cancers (DCIS) and 26 (90 %) were invasive breast cancers including 3 multifocal or multicentric cancers. All 26 detected invasive cancers were lymph-node negative and 25/29 (86 %) of the detected breast cancer were early stage cancers (stage 0 or 1). 53 of the 135 MRI exams (39.3 %) were suspicious for malignancy (BIRADS 4 or 5) with no cancer missed by MRI. The sensitivity, specificity, positive predictive value, and negative predictive value of the MRI on a per patient basis were 100 %, 77 %, 0.53, and 1, respectively. CONCLUSION: MRI is a useful problem-solving tool in mammography screening assessment with a high sensitivity and an acceptable positive predictive value. SN - 1438-9010 UR - https://www.unboundmedicine.com/medline/citation/23740312/MRI_of_the_breast_as_part_of_the_assessment_in_population_based_mammography_screening_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0033-1335518 DB - PRIME DP - Unbound Medicine ER -