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Mortality of subjects with alcohol-related seizures increased after alcohol cheapening.
Acta Neurol Scand. 2014 Jan; 129(1):56-60.AN

Abstract

OBJECTIVE

To investigate whether the reduction of alcohol prices in Finland (March 1, 2004) associated with an increase in mortality of subjects with alcohol-related seizures.

PATIENTS AND METHODS

All subjects with head trauma in Oulu University Hospital during 1999 (n = 827) were identified and thereafter followed up until death or the end of 2009. We used National Hospital Discharge Register, hospital charts, and death records from Official Cause-of-Death Statistics to identify seizure visits and alcohol-related deaths. Kaplan-Meier survival curves were used to characterize the effect of alcohol price reduction on risk of death. Cox proportional hazards model was used to identify independent predictors of death.

RESULTS

Twenty-five subjects had alcohol-related seizures before the alcohol price reduction. Their cumulative mortality rate was significantly higher (P = 0.015) than that of other head trauma subjects during the follow-up and it clearly increased after the price reduction. Age (HR 1.06 per year, 95% CI 1.05-1.07, P < 0.001), moderate-to-severe traumatic brain injury (HR 2.04 95% CI 1.37-3.04, P < 0.001), and alcohol-related seizure (HR 3.02, 95% CI 1.48-6.16, P = 0.002) were independent predictors of death after adjustment for confounding factors.

CONCLUSION

We conclude that the political decision to lower alcohol price associated with a significant increase in the mortality rate of subjects with alcohol-related seizures.

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Authors+Show Affiliations

Vaaramo K
Department of Neurology, University of Oulu and Oulu University Hospital, Oulu, Finland.
Puljula J
No affiliation info available
Tetri S
No affiliation info available
Juvela S
No affiliation info available
Hillbom M
No affiliation info available

MeSH

AdultAlcohol Withdrawal SeizuresAlcoholic BeveragesBrain InjuriesFemaleFinlandHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMortalityProportional Hazards ModelsTaxesTrauma Severity IndicesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23742242

Citation

Vaaramo, K, et al. "Mortality of Subjects With Alcohol-related Seizures Increased After Alcohol Cheapening." Acta Neurologica Scandinavica, vol. 129, no. 1, 2014, pp. 56-60.
Vaaramo K, Puljula J, Tetri S, et al. Mortality of subjects with alcohol-related seizures increased after alcohol cheapening. Acta Neurol Scand. 2014;129(1):56-60.
Vaaramo, K., Puljula, J., Tetri, S., Juvela, S., & Hillbom, M. (2014). Mortality of subjects with alcohol-related seizures increased after alcohol cheapening. Acta Neurologica Scandinavica, 129(1), 56-60. https://doi.org/10.1111/ane.12150
Vaaramo K, et al. Mortality of Subjects With Alcohol-related Seizures Increased After Alcohol Cheapening. Acta Neurol Scand. 2014;129(1):56-60. PubMed PMID: 23742242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality of subjects with alcohol-related seizures increased after alcohol cheapening. AU - Vaaramo,K, AU - Puljula,J, AU - Tetri,S, AU - Juvela,S, AU - Hillbom,M, Y1 - 2013/06/07/ PY - 2013/04/22/accepted PY - 2013/6/8/entrez PY - 2013/6/8/pubmed PY - 2014/4/15/medline KW - alcohol KW - alcohol policy KW - alcohol price reduction KW - head injury KW - mortality rate KW - seizures SP - 56 EP - 60 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 129 IS - 1 N2 - OBJECTIVE: To investigate whether the reduction of alcohol prices in Finland (March 1, 2004) associated with an increase in mortality of subjects with alcohol-related seizures. PATIENTS AND METHODS: All subjects with head trauma in Oulu University Hospital during 1999 (n = 827) were identified and thereafter followed up until death or the end of 2009. We used National Hospital Discharge Register, hospital charts, and death records from Official Cause-of-Death Statistics to identify seizure visits and alcohol-related deaths. Kaplan-Meier survival curves were used to characterize the effect of alcohol price reduction on risk of death. Cox proportional hazards model was used to identify independent predictors of death. RESULTS: Twenty-five subjects had alcohol-related seizures before the alcohol price reduction. Their cumulative mortality rate was significantly higher (P = 0.015) than that of other head trauma subjects during the follow-up and it clearly increased after the price reduction. Age (HR 1.06 per year, 95% CI 1.05-1.07, P < 0.001), moderate-to-severe traumatic brain injury (HR 2.04 95% CI 1.37-3.04, P < 0.001), and alcohol-related seizure (HR 3.02, 95% CI 1.48-6.16, P = 0.002) were independent predictors of death after adjustment for confounding factors. CONCLUSION: We conclude that the political decision to lower alcohol price associated with a significant increase in the mortality rate of subjects with alcohol-related seizures. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/23742242/Mortality_of_subjects_with_alcohol_related_seizures_increased_after_alcohol_cheapening_ L2 - https://doi.org/10.1111/ane.12150 DB - PRIME DP - Unbound Medicine ER -