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A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2.
Pharm Biol. 2013 Aug; 51(8):1077-80.PB

Abstract

CONTEXT

Chemical compositions of three herbal plants from the family Araliaceae genus Panax [Panax ginseng C. A. Mey, P. quinquefolius L. and P. notoginseng (Burk.) F. H. Chen] are quite similar; however, their medicinal natures vary greatly. The reason for differences has been explained in traditional Chinese medicine theory and partially verified by modern pharmacological investigations, such as antiplatelet aggregation. Aside from platelet aggregation, a variety of plasma coagulation factors are also involved in blood coagulation. The anticoagulation profiles of three herbs have not been investigated.

OBJECTIVE

The current research compared the inhibitory effects of three herbal extracts from Panax spp. and the purified ginsenosides from P. ginseng on blood coagulation.

MATERIALS AND METHODS

Human plasma was mixed with the water extracts (0.05 and 0.1 mg/mL) from roots of P. ginseng, P. quinquefolius and P. notoginseng and ginsenosides Rg1 and Rg2 (0.05 and 0.1 mg/mL), the blood clotting time of activated partial thromboplastin, prothrombin and thrombin were measured by a biochemical analyzer.

RESULTS

The water extracts (0.05 mg/mL) of P. ginseng, P. quinquefolius and P. notoginseng could significantly extend blood clotting time as compared to the control group. Among three herbal medicines, 0.05 mg/mL of water extract from P. ginseng exhibited the strongest anticoagulation effects, followed by P. notoginseng, while P. quinquefolius presented the weakest effects. Both ginsenosides Rg1 and Rg2 could significantly extend blood clotting time in all three tests; ginsenoside Rg2 exhibited relative stronger anticoagulation effects as compared to ginsenoside Rg1.

DISCUSSION AND CONCLUSION

Among three herbs tested, P. ginseng as well as its active component ginsenoside Rg2 shows the strongest anticoagulation activity; current results indicate that P. ginseng and ginsenoside Rg2 have great potential to be an anticoagulation drug.

Authors+Show Affiliations

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23742679

Citation

Li, C T., et al. "A Comparative Study On Anticoagulant Activities of Three Chinese Herbal Medicines From the Genus Panax and Anticoagulant Activities of Ginsenosides Rg1 and Rg2." Pharmaceutical Biology, vol. 51, no. 8, 2013, pp. 1077-80.
Li CT, Wang HB, Xu BJ. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. Pharm Biol. 2013;51(8):1077-80.
Li, C. T., Wang, H. B., & Xu, B. J. (2013). A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. Pharmaceutical Biology, 51(8), 1077-80. https://doi.org/10.3109/13880209.2013.775164
Li CT, Wang HB, Xu BJ. A Comparative Study On Anticoagulant Activities of Three Chinese Herbal Medicines From the Genus Panax and Anticoagulant Activities of Ginsenosides Rg1 and Rg2. Pharm Biol. 2013;51(8):1077-80. PubMed PMID: 23742679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. AU - Li,C T, AU - Wang,H B, AU - Xu,B J, Y1 - 2013/06/06/ PY - 2013/6/8/entrez PY - 2013/6/8/pubmed PY - 2014/2/14/medline SP - 1077 EP - 80 JF - Pharmaceutical biology JO - Pharm Biol VL - 51 IS - 8 N2 - CONTEXT: Chemical compositions of three herbal plants from the family Araliaceae genus Panax [Panax ginseng C. A. Mey, P. quinquefolius L. and P. notoginseng (Burk.) F. H. Chen] are quite similar; however, their medicinal natures vary greatly. The reason for differences has been explained in traditional Chinese medicine theory and partially verified by modern pharmacological investigations, such as antiplatelet aggregation. Aside from platelet aggregation, a variety of plasma coagulation factors are also involved in blood coagulation. The anticoagulation profiles of three herbs have not been investigated. OBJECTIVE: The current research compared the inhibitory effects of three herbal extracts from Panax spp. and the purified ginsenosides from P. ginseng on blood coagulation. MATERIALS AND METHODS: Human plasma was mixed with the water extracts (0.05 and 0.1 mg/mL) from roots of P. ginseng, P. quinquefolius and P. notoginseng and ginsenosides Rg1 and Rg2 (0.05 and 0.1 mg/mL), the blood clotting time of activated partial thromboplastin, prothrombin and thrombin were measured by a biochemical analyzer. RESULTS: The water extracts (0.05 mg/mL) of P. ginseng, P. quinquefolius and P. notoginseng could significantly extend blood clotting time as compared to the control group. Among three herbal medicines, 0.05 mg/mL of water extract from P. ginseng exhibited the strongest anticoagulation effects, followed by P. notoginseng, while P. quinquefolius presented the weakest effects. Both ginsenosides Rg1 and Rg2 could significantly extend blood clotting time in all three tests; ginsenoside Rg2 exhibited relative stronger anticoagulation effects as compared to ginsenoside Rg1. DISCUSSION AND CONCLUSION: Among three herbs tested, P. ginseng as well as its active component ginsenoside Rg2 shows the strongest anticoagulation activity; current results indicate that P. ginseng and ginsenoside Rg2 have great potential to be an anticoagulation drug. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/23742679/A_comparative_study_on_anticoagulant_activities_of_three_Chinese_herbal_medicines_from_the_genus_Panax_and_anticoagulant_activities_of_ginsenosides_Rg1_and_Rg2_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2013.775164 DB - PRIME DP - Unbound Medicine ER -