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Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats.
Food Chem Toxicol. 2013 Sep; 59:153-9.FC

Abstract

AIM OF THE STUDY

Korean red ginseng is one of the best selling dietary supplements and its individual constituents enhance renal function. Acute renal failure (ARF) is a predisposing complication of diabetes mellitus as a result of combination drug therapy. The combination of antibiotic-antidiabetic drugs can entail toxicities and drug interactions because of the antibiotic resistance in patients with severe bacterial infection. Currently, gentamicin-metformin combination therapy is commonly prescribed for treating bacterial infections and diabetes, even though both drugs are mainly excreted via the kidney. Thus, this study was designed to investigate whether a Korean red ginseng extract (KRG) prevents renal impairment and pharmacokinetic changes by metformin in rats with renal failure induced by gentamicin.

MATERIALS AND METHODS

The in vivo pharmacokinetics and in vitro hepatic/intestinal metabolism of metformin were assessed using control (CON), control with Korean red ginseng extract (KRG-CON), acute renal failure induced by gentamicin (ARF), and ARF with Korean red ginseng (KRG-ARF) rats.

RESULTS AND CONCLUSIONS

Pharmacokinetic changes of metformin did not occur in KRG-ARF rats because KRG reduce the renal accumulation of gentamicin compared to ARF rats. Thus, KRG seemed to prevent acute renal failure induced by gentamicin treatment.

Authors+Show Affiliations

College of Pharmacy, Dongguk University-Seoul, Ilsandong-gu, Goyang, Gyeonggi-do, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23743120

Citation

Lee, Yu Kyung, et al. "Effects of Korean Red Ginseng Extract On Acute Renal Failure Induced By Gentamicin and Pharmacokinetic Changes By Metformin in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 59, 2013, pp. 153-9.
Lee YK, Chin YW, Choi YH. Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. Food Chem Toxicol. 2013;59:153-9.
Lee, Y. K., Chin, Y. W., & Choi, Y. H. (2013). Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 59, 153-9. https://doi.org/10.1016/j.fct.2013.05.025
Lee YK, Chin YW, Choi YH. Effects of Korean Red Ginseng Extract On Acute Renal Failure Induced By Gentamicin and Pharmacokinetic Changes By Metformin in Rats. Food Chem Toxicol. 2013;59:153-9. PubMed PMID: 23743120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. AU - Lee,Yu Kyung, AU - Chin,Young-Won, AU - Choi,Young Hee, Y1 - 2013/06/03/ PY - 2012/12/24/received PY - 2013/05/02/revised PY - 2013/05/07/accepted PY - 2013/6/8/entrez PY - 2013/6/8/pubmed PY - 2014/3/29/medline KW - Acute renal failure KW - Gentamicin KW - Korean red ginseng extract KW - Metformin KW - Pharmacokinetics KW - Prevention SP - 153 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 59 N2 - AIM OF THE STUDY: Korean red ginseng is one of the best selling dietary supplements and its individual constituents enhance renal function. Acute renal failure (ARF) is a predisposing complication of diabetes mellitus as a result of combination drug therapy. The combination of antibiotic-antidiabetic drugs can entail toxicities and drug interactions because of the antibiotic resistance in patients with severe bacterial infection. Currently, gentamicin-metformin combination therapy is commonly prescribed for treating bacterial infections and diabetes, even though both drugs are mainly excreted via the kidney. Thus, this study was designed to investigate whether a Korean red ginseng extract (KRG) prevents renal impairment and pharmacokinetic changes by metformin in rats with renal failure induced by gentamicin. MATERIALS AND METHODS: The in vivo pharmacokinetics and in vitro hepatic/intestinal metabolism of metformin were assessed using control (CON), control with Korean red ginseng extract (KRG-CON), acute renal failure induced by gentamicin (ARF), and ARF with Korean red ginseng (KRG-ARF) rats. RESULTS AND CONCLUSIONS: Pharmacokinetic changes of metformin did not occur in KRG-ARF rats because KRG reduce the renal accumulation of gentamicin compared to ARF rats. Thus, KRG seemed to prevent acute renal failure induced by gentamicin treatment. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23743120/Effects_of_Korean_red_ginseng_extract_on_acute_renal_failure_induced_by_gentamicin_and_pharmacokinetic_changes_by_metformin_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00331-1 DB - PRIME DP - Unbound Medicine ER -