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Tick bites and red meat allergy.

Abstract

PURPOSE OF REVIEW

A novel form of anaphylaxis has been described that is due to IgE antibody (Ab) directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). Ongoing work regarding the cause and distribution of this IgE response is reviewed.

RECENT FINDINGS

Our recent work has identified a novel IgE Ab response that has been associated with two distinct forms of anaphylaxis: immediate-onset anaphylaxis during first exposure to intravenous cetuximab and delayed-onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g. beef and pork). Further studies strongly suggested that tick bites were a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the United States and internationally.

SUMMARY

Large numbers of patients with IgE Ab to alpha-gal continue to be identified in the USA and globally. Clinicians should be aware of this IgE response as the reactions often appear to be idiopathic because of the significant delay between eating mammalian meat and the appearance of symptoms.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Division of Allergy and Immunology, University of Virginia Health System, Charlottesville, Virginia 22908, USA. scottcommins@virginia.edu

    Source

    MeSH

    Anaphylaxis
    Animals
    Disaccharidases
    Epitopes
    Food Hypersensitivity
    Humans
    Immunoglobulin E
    Meat
    Tick Bites
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    23743512

    Citation

    Commins, Scott P., and Thomas A E. Platts-Mills. "Tick Bites and Red Meat Allergy." Current Opinion in Allergy and Clinical Immunology, vol. 13, no. 4, 2013, pp. 354-9.
    Commins SP, Platts-Mills TA. Tick bites and red meat allergy. Curr Opin Allergy Clin Immunol. 2013;13(4):354-9.
    Commins, S. P., & Platts-Mills, T. A. (2013). Tick bites and red meat allergy. Current Opinion in Allergy and Clinical Immunology, 13(4), pp. 354-9. doi:10.1097/ACI.0b013e3283624560.
    Commins SP, Platts-Mills TA. Tick Bites and Red Meat Allergy. Curr Opin Allergy Clin Immunol. 2013;13(4):354-9. PubMed PMID: 23743512.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tick bites and red meat allergy. AU - Commins,Scott P, AU - Platts-Mills,Thomas A E, PY - 2013/6/8/entrez PY - 2013/6/8/pubmed PY - 2014/2/5/medline SP - 354 EP - 9 JF - Current opinion in allergy and clinical immunology JO - Curr Opin Allergy Clin Immunol VL - 13 IS - 4 N2 - PURPOSE OF REVIEW: A novel form of anaphylaxis has been described that is due to IgE antibody (Ab) directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). Ongoing work regarding the cause and distribution of this IgE response is reviewed. RECENT FINDINGS: Our recent work has identified a novel IgE Ab response that has been associated with two distinct forms of anaphylaxis: immediate-onset anaphylaxis during first exposure to intravenous cetuximab and delayed-onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g. beef and pork). Further studies strongly suggested that tick bites were a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the United States and internationally. SUMMARY: Large numbers of patients with IgE Ab to alpha-gal continue to be identified in the USA and globally. Clinicians should be aware of this IgE response as the reactions often appear to be idiopathic because of the significant delay between eating mammalian meat and the appearance of symptoms. SN - 1473-6322 UR - https://www.unboundmedicine.com/medline/citation/23743512/Tick_bites_and_red_meat_allergy_ L2 - http://Insights.ovid.com/pubmed?pmid=23743512 DB - PRIME DP - Unbound Medicine ER -