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Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes.
Invest Ophthalmol Vis Sci. 2013 Jul 26; 54(7):5035-48.IO

Abstract

PURPOSE

To determine if the accommodative forward movements of the vitreous zonule and lens equator occur in the human eye, as they do in the rhesus monkey eye; to investigate the connection between the vitreous zonule posterior insertion zone and the posterior lens equator; and to determine which components-muscle apex width, lens thickness, lens equator position, vitreous zonule, circumlental space, and/or other intraocular dimensions, including those stated in the objectives above-are most important in predicting accommodative amplitude and presbyopia.

METHODS

Accommodation was induced pharmacologically in 12 visually normal human subjects (ages 19-65 years) and by midbrain electrical stimulation in 11 rhesus monkeys (ages 6-27 years). Ultrasound biomicroscopy imaged the entire ciliary body, anterior and posterior lens surfaces, and the zonule. Relevant distances were measured in the resting and accommodated eyes. Stepwise regression analysis determined which variables were the most important predictors.

RESULTS

The human vitreous zonule and lens equator move forward (anteriorly) during accommodation, and their movements decline with age, as in the monkey. Over all ages studied, age could explain accommodative amplitude, but not as well as accommodative lens thickening and resting muscle apex thickness did together. Accommodative change in distances between the vitreous zonule insertion zone and the posterior lens equator or muscle apex were important for predicting accommodative lens thickening.

CONCLUSIONS

Our findings quantify the movements of the zonule and ciliary muscle during accommodation, and identify their age-related changes that could impact the optical change that occurs during accommodation and IOL function.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53792-3220, USA. macroft@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23745002

Citation

Croft, Mary Ann, et al. "Extralenticular and Lenticular Aspects of Accommodation and Presbyopia in Human Versus Monkey Eyes." Investigative Ophthalmology & Visual Science, vol. 54, no. 7, 2013, pp. 5035-48.
Croft MA, McDonald JP, Katz A, et al. Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes. Invest Ophthalmol Vis Sci. 2013;54(7):5035-48.
Croft, M. A., McDonald, J. P., Katz, A., Lin, T. L., Lütjen-Drecoll, E., & Kaufman, P. L. (2013). Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes. Investigative Ophthalmology & Visual Science, 54(7), 5035-48. https://doi.org/10.1167/iovs.12-10846
Croft MA, et al. Extralenticular and Lenticular Aspects of Accommodation and Presbyopia in Human Versus Monkey Eyes. Invest Ophthalmol Vis Sci. 2013 Jul 26;54(7):5035-48. PubMed PMID: 23745002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes. AU - Croft,Mary Ann, AU - McDonald,Jared P, AU - Katz,Alexander, AU - Lin,Ting-Li, AU - Lütjen-Drecoll,Elke, AU - Kaufman,Paul L, Y1 - 2013/07/26/ PY - 2013/6/8/entrez PY - 2013/6/8/pubmed PY - 2013/10/1/medline KW - accommodation KW - ciliary muscle KW - human KW - lens KW - presbyopia SP - 5035 EP - 48 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 54 IS - 7 N2 - PURPOSE: To determine if the accommodative forward movements of the vitreous zonule and lens equator occur in the human eye, as they do in the rhesus monkey eye; to investigate the connection between the vitreous zonule posterior insertion zone and the posterior lens equator; and to determine which components-muscle apex width, lens thickness, lens equator position, vitreous zonule, circumlental space, and/or other intraocular dimensions, including those stated in the objectives above-are most important in predicting accommodative amplitude and presbyopia. METHODS: Accommodation was induced pharmacologically in 12 visually normal human subjects (ages 19-65 years) and by midbrain electrical stimulation in 11 rhesus monkeys (ages 6-27 years). Ultrasound biomicroscopy imaged the entire ciliary body, anterior and posterior lens surfaces, and the zonule. Relevant distances were measured in the resting and accommodated eyes. Stepwise regression analysis determined which variables were the most important predictors. RESULTS: The human vitreous zonule and lens equator move forward (anteriorly) during accommodation, and their movements decline with age, as in the monkey. Over all ages studied, age could explain accommodative amplitude, but not as well as accommodative lens thickening and resting muscle apex thickness did together. Accommodative change in distances between the vitreous zonule insertion zone and the posterior lens equator or muscle apex were important for predicting accommodative lens thickening. CONCLUSIONS: Our findings quantify the movements of the zonule and ciliary muscle during accommodation, and identify their age-related changes that could impact the optical change that occurs during accommodation and IOL function. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/23745002/Extralenticular_and_lenticular_aspects_of_accommodation_and_presbyopia_in_human_versus_monkey_eyes_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.12-10846 DB - PRIME DP - Unbound Medicine ER -