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Treatment of necrobiotic xanthogranuloma with 2-chlorodeoxyadenosine.

Abstract

A 71-year-old man presented with ulcerating yellow-red plaques of the back, chest, face, and extremities (Figure 1). He had a 10-year history of these lesions. The initial plaque appeared on the back followed by rapid progression of multiple similar lesions involving the face, chest, abdomen, and extremities. The plaques on his face were predominately in the periorbital and eyelid regions. Skin biopsy revealed an ulcerated epidermis. Dense sheets of foamy histiocytes were present in the dermis and contained foci of necrobiosis. Numerous Touton giant cells were present and cholesterol clefts were prominent. Special stains for organisms were negative. On further laboratory evaluation, serum protein electrophoresis revealed a monoclonal spike of 0.5 g/dL IgG lambda. Results from bone marrow biopsy were negative. Other significant laboratory findings included an elevated sedimentation rate and low serum complement. Clinical findings, histopathology, and laboratory evaluations were consistent with the diagnosis of necrobiotic xanthogranuloma (NXG).

Authors+Show Affiliations

,

University of Nebraska Medical Center, 2212 South 64th Plaza #401, Omaha, NE 68106, USA. leighmsutton@gmail.com

,

Source

Skinmed 11:2 pg 121-3

MeSH

Aged
Antineoplastic Agents
Biopsy
Blood Protein Electrophoresis
Cladribine
Disease Progression
Humans
Immunoglobulin G
Immunoglobulin lambda-Chains
Male
Necrobiotic Xanthogranuloma
Treatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

23745232

Citation

Sutton, Leigh, et al. "Treatment of Necrobiotic Xanthogranuloma With 2-chlorodeoxyadenosine." Skinmed, vol. 11, no. 2, 2013, pp. 121-3.
Sutton L, Sutton S, Sutton M. Treatment of necrobiotic xanthogranuloma with 2-chlorodeoxyadenosine. Skinmed. 2013;11(2):121-3.
Sutton, L., Sutton, S., & Sutton, M. (2013). Treatment of necrobiotic xanthogranuloma with 2-chlorodeoxyadenosine. Skinmed, 11(2), pp. 121-3.
Sutton L, Sutton S, Sutton M. Treatment of Necrobiotic Xanthogranuloma With 2-chlorodeoxyadenosine. Skinmed. 2013;11(2):121-3. PubMed PMID: 23745232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of necrobiotic xanthogranuloma with 2-chlorodeoxyadenosine. AU - Sutton,Leigh, AU - Sutton,Stephanie, AU - Sutton,Margaret, PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2013/7/11/medline SP - 121 EP - 3 JF - Skinmed JO - Skinmed VL - 11 IS - 2 N2 - A 71-year-old man presented with ulcerating yellow-red plaques of the back, chest, face, and extremities (Figure 1). He had a 10-year history of these lesions. The initial plaque appeared on the back followed by rapid progression of multiple similar lesions involving the face, chest, abdomen, and extremities. The plaques on his face were predominately in the periorbital and eyelid regions. Skin biopsy revealed an ulcerated epidermis. Dense sheets of foamy histiocytes were present in the dermis and contained foci of necrobiosis. Numerous Touton giant cells were present and cholesterol clefts were prominent. Special stains for organisms were negative. On further laboratory evaluation, serum protein electrophoresis revealed a monoclonal spike of 0.5 g/dL IgG lambda. Results from bone marrow biopsy were negative. Other significant laboratory findings included an elevated sedimentation rate and low serum complement. Clinical findings, histopathology, and laboratory evaluations were consistent with the diagnosis of necrobiotic xanthogranuloma (NXG). SN - 1540-9740 UR - https://www.unboundmedicine.com/medline/citation/23745232/Treatment_of_necrobiotic_xanthogranuloma_with_2_chlorodeoxyadenosine_ L2 - http://www.diseaseinfosearch.org/result/7560 DB - PRIME DP - Unbound Medicine ER -