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A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile.

OBJECTIVE

To compare the cardiovascular risk profile of women with PCOS alone and women with PCOS and NAFLD.

DESIGN, SETTING AND PARTICIPANTS

Twenty-five oligoanovulatory women with PCOS were screened for NAFLD (including liver biopsy if appropriate) and had their cardiovascular risk factors measured which included the inflammatory marker C-reactive protein (CRP), endothelial function {measured using endoPAT 2000 and serum markers [intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin]}, clot structure and function [maximum absorbance (MA) and lysis potential (LT)].

RESULTS

Twelve patients had confirmed PCOS without evidence of NAFLD, and 13 patients had confirmed PCOS with evidence of NAFLD. The PCOS and NAFLD group were heavier (BMI 43·9 ± 2·2 kg/m(2) ) compared with the PCOS alone group (BMI 37·6 ± 1·4 kg/m(2) P = 0·03). There was no difference in CRP (7·57 ± 0·95 vs 6·59 ± 1·87 mm P = 0·62) or endothelial function (RH-PAT 1·96 ± 0·1 vs 1·74 ± 0·16 P = 0·25), ICAM-1 (221 ± 48 vs 250 ± 60 ng/ml P = 0·19), VCAM-1 (2124 ± 78 vs 2314 ± 91 ng/ml P = 0·13), E-selectin (33·9 ± 3·3 vs 39·5 ± 15·5 ng/ml P = 0·31) and P-selectin (101·0 ± 6·6 vs 95·9 ± 10·2 ng/ml P = 0·69). There was no difference in clot formation or lysis.

CONCLUSION

The patients with PCOS and NAFLD were heavier compared with patients with PCOS alone. Despite this, we were unable to demonstrate differences in inflammatory markers, endothelial function or clot structure and function, suggesting that severity of steatosis is not the most important determinant of cardiovascular risk in PCOS.

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  • Authors+Show Affiliations

    ,

    Department of Diabetes and Endocrinology, University of Hull, Hull, UK.

    , , , , , ,

    Source

    Clinical endocrinology 80:6 2014 Jun pg 843-9

    MeSH

    Adult
    Biopsy
    C-Reactive Protein
    Cardiovascular Diseases
    Cardiovascular System
    E-Selectin
    Female
    Fibrinolysis
    Humans
    Inflammation
    Insulin Resistance
    Intercellular Adhesion Molecule-1
    Non-alcoholic Fatty Liver Disease
    P-Selectin
    Polycystic Ovary Syndrome
    Risk Factors
    Vascular Cell Adhesion Molecule-1
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    23746214

    Citation

    Dawson, Alison J., et al. "A Comparison of Cardiovascular Risk Indices in Patients With Polycystic Ovary Syndrome With and Without Coexisting Nonalcoholic Fatty Liver Disease." Clinical Endocrinology, vol. 80, no. 6, 2014, pp. 843-9.
    Dawson AJ, Sathyapalan T, Smithson JA, et al. A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). 2014;80(6):843-9.
    Dawson, A. J., Sathyapalan, T., Smithson, J. A., Vince, R. V., Coady, A. M., Ajjan, R., ... Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), pp. 843-9. doi:10.1111/cen.12258.
    Dawson AJ, et al. A Comparison of Cardiovascular Risk Indices in Patients With Polycystic Ovary Syndrome With and Without Coexisting Nonalcoholic Fatty Liver Disease. Clin Endocrinol (Oxf). 2014;80(6):843-9. PubMed PMID: 23746214.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. AU - Dawson,Alison J, AU - Sathyapalan,Thozhukat, AU - Smithson,Jacqueline A J, AU - Vince,Rebecca V, AU - Coady,Anne-Marie, AU - Ajjan,Ramzi, AU - Kilpatrick,Eric S, AU - Atkin,Stephen L, Y1 - 2013/08/26/ PY - 2012/09/04/received PY - 2012/10/03/revised PY - 2013/04/29/revised PY - 2013/06/03/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/12/17/medline SP - 843 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 80 IS - 6 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. OBJECTIVE: To compare the cardiovascular risk profile of women with PCOS alone and women with PCOS and NAFLD. DESIGN, SETTING AND PARTICIPANTS: Twenty-five oligoanovulatory women with PCOS were screened for NAFLD (including liver biopsy if appropriate) and had their cardiovascular risk factors measured which included the inflammatory marker C-reactive protein (CRP), endothelial function {measured using endoPAT 2000 and serum markers [intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin]}, clot structure and function [maximum absorbance (MA) and lysis potential (LT)]. RESULTS: Twelve patients had confirmed PCOS without evidence of NAFLD, and 13 patients had confirmed PCOS with evidence of NAFLD. The PCOS and NAFLD group were heavier (BMI 43·9 ± 2·2 kg/m(2) ) compared with the PCOS alone group (BMI 37·6 ± 1·4 kg/m(2) P = 0·03). There was no difference in CRP (7·57 ± 0·95 vs 6·59 ± 1·87 mm P = 0·62) or endothelial function (RH-PAT 1·96 ± 0·1 vs 1·74 ± 0·16 P = 0·25), ICAM-1 (221 ± 48 vs 250 ± 60 ng/ml P = 0·19), VCAM-1 (2124 ± 78 vs 2314 ± 91 ng/ml P = 0·13), E-selectin (33·9 ± 3·3 vs 39·5 ± 15·5 ng/ml P = 0·31) and P-selectin (101·0 ± 6·6 vs 95·9 ± 10·2 ng/ml P = 0·69). There was no difference in clot formation or lysis. CONCLUSION: The patients with PCOS and NAFLD were heavier compared with patients with PCOS alone. Despite this, we were unable to demonstrate differences in inflammatory markers, endothelial function or clot structure and function, suggesting that severity of steatosis is not the most important determinant of cardiovascular risk in PCOS. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/23746214/A_comparison_of_cardiovascular_risk_indices_in_patients_with_polycystic_ovary_syndrome_with_and_without_coexisting_nonalcoholic_fatty_liver_disease L2 - https://doi.org/10.1111/cen.12258 DB - PRIME DP - Unbound Medicine ER -