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A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.
Clin Endocrinol (Oxf) 2014; 80(6):843-9CE

Abstract

BACKGROUND

Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile.

OBJECTIVE

To compare the cardiovascular risk profile of women with PCOS alone and women with PCOS and NAFLD.

DESIGN, SETTING AND PARTICIPANTS

Twenty-five oligoanovulatory women with PCOS were screened for NAFLD (including liver biopsy if appropriate) and had their cardiovascular risk factors measured which included the inflammatory marker C-reactive protein (CRP), endothelial function {measured using endoPAT 2000 and serum markers [intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin]}, clot structure and function [maximum absorbance (MA) and lysis potential (LT)].

RESULTS

Twelve patients had confirmed PCOS without evidence of NAFLD, and 13 patients had confirmed PCOS with evidence of NAFLD. The PCOS and NAFLD group were heavier (BMI 43·9 ± 2·2 kg/m(2)) compared with the PCOS alone group (BMI 37·6 ± 1·4 kg/m(2) P = 0·03). There was no difference in CRP (7·57 ± 0·95 vs 6·59 ± 1·87 mm P = 0·62) or endothelial function (RH-PAT 1·96 ± 0·1 vs 1·74 ± 0·16 P = 0·25), ICAM-1 (221 ± 48 vs 250 ± 60 ng/ml P = 0·19), VCAM-1 (2124 ± 78 vs 2314 ± 91 ng/ml P = 0·13), E-selectin (33·9 ± 3·3 vs 39·5 ± 15·5 ng/ml P = 0·31) and P-selectin (101·0 ± 6·6 vs 95·9 ± 10·2 ng/ml P = 0·69). There was no difference in clot formation or lysis.

CONCLUSION

The patients with PCOS and NAFLD were heavier compared with patients with PCOS alone. Despite this, we were unable to demonstrate differences in inflammatory markers, endothelial function or clot structure and function, suggesting that severity of steatosis is not the most important determinant of cardiovascular risk in PCOS.

Authors+Show Affiliations

Department of Diabetes and Endocrinology, University of Hull, Hull, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23746214

Citation

Dawson, Alison J., et al. "A Comparison of Cardiovascular Risk Indices in Patients With Polycystic Ovary Syndrome With and Without Coexisting Nonalcoholic Fatty Liver Disease." Clinical Endocrinology, vol. 80, no. 6, 2014, pp. 843-9.
Dawson AJ, Sathyapalan T, Smithson JA, et al. A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). 2014;80(6):843-9.
Dawson, A. J., Sathyapalan, T., Smithson, J. A., Vince, R. V., Coady, A. M., Ajjan, R., ... Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), pp. 843-9. doi:10.1111/cen.12258.
Dawson AJ, et al. A Comparison of Cardiovascular Risk Indices in Patients With Polycystic Ovary Syndrome With and Without Coexisting Nonalcoholic Fatty Liver Disease. Clin Endocrinol (Oxf). 2014;80(6):843-9. PubMed PMID: 23746214.
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TY - JOUR T1 - A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. AU - Dawson,Alison J, AU - Sathyapalan,Thozhukat, AU - Smithson,Jacqueline A J, AU - Vince,Rebecca V, AU - Coady,Anne-Marie, AU - Ajjan,Ramzi, AU - Kilpatrick,Eric S, AU - Atkin,Stephen L, Y1 - 2013/08/26/ PY - 2012/09/04/received PY - 2012/10/03/revised PY - 2013/04/29/revised PY - 2013/06/03/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/12/17/medline SP - 843 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 80 IS - 6 N2 - BACKGROUND: Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. OBJECTIVE: To compare the cardiovascular risk profile of women with PCOS alone and women with PCOS and NAFLD. DESIGN, SETTING AND PARTICIPANTS: Twenty-five oligoanovulatory women with PCOS were screened for NAFLD (including liver biopsy if appropriate) and had their cardiovascular risk factors measured which included the inflammatory marker C-reactive protein (CRP), endothelial function {measured using endoPAT 2000 and serum markers [intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin and P-selectin]}, clot structure and function [maximum absorbance (MA) and lysis potential (LT)]. RESULTS: Twelve patients had confirmed PCOS without evidence of NAFLD, and 13 patients had confirmed PCOS with evidence of NAFLD. The PCOS and NAFLD group were heavier (BMI 43·9 ± 2·2 kg/m(2)) compared with the PCOS alone group (BMI 37·6 ± 1·4 kg/m(2) P = 0·03). There was no difference in CRP (7·57 ± 0·95 vs 6·59 ± 1·87 mm P = 0·62) or endothelial function (RH-PAT 1·96 ± 0·1 vs 1·74 ± 0·16 P = 0·25), ICAM-1 (221 ± 48 vs 250 ± 60 ng/ml P = 0·19), VCAM-1 (2124 ± 78 vs 2314 ± 91 ng/ml P = 0·13), E-selectin (33·9 ± 3·3 vs 39·5 ± 15·5 ng/ml P = 0·31) and P-selectin (101·0 ± 6·6 vs 95·9 ± 10·2 ng/ml P = 0·69). There was no difference in clot formation or lysis. CONCLUSION: The patients with PCOS and NAFLD were heavier compared with patients with PCOS alone. Despite this, we were unable to demonstrate differences in inflammatory markers, endothelial function or clot structure and function, suggesting that severity of steatosis is not the most important determinant of cardiovascular risk in PCOS. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/23746214/A_comparison_of_cardiovascular_risk_indices_in_patients_with_polycystic_ovary_syndrome_with_and_without_coexisting_nonalcoholic_fatty_liver_disease L2 - https://doi.org/10.1111/cen.12258 DB - PRIME DP - Unbound Medicine ER -