Citation
Pumarola, Felix, et al. "Microbiology of Bacteria Causing Recurrent Acute Otitis Media (AOM) and AOM Treatment Failure in Young Children in Spain: Shifting Pathogens in the Post-pneumococcal Conjugate Vaccination Era." International Journal of Pediatric Otorhinolaryngology, vol. 77, no. 8, 2013, pp. 1231-6.
Pumarola F, Marès J, Losada I, et al. Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era. Int J Pediatr Otorhinolaryngol. 2013;77(8):1231-6.
Pumarola, F., Marès, J., Losada, I., Minguella, I., Moraga, F., Tarragó, D., Aguilera, U., Casanovas, J. M., Gadea, G., Trías, E., Cenoz, S., Sistiaga, A., García-Corbeira, P., Pirçon, J. Y., Marano, C., & Hausdorff, W. P. (2013). Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era. International Journal of Pediatric Otorhinolaryngology, 77(8), 1231-6. https://doi.org/10.1016/j.ijporl.2013.04.002
Pumarola F, et al. Microbiology of Bacteria Causing Recurrent Acute Otitis Media (AOM) and AOM Treatment Failure in Young Children in Spain: Shifting Pathogens in the Post-pneumococcal Conjugate Vaccination Era. Int J Pediatr Otorhinolaryngol. 2013;77(8):1231-6. PubMed PMID: 23746414.
TY - JOUR
T1 - Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era.
AU - Pumarola,Felix,
AU - Marès,Josep,
AU - Losada,Isabel,
AU - Minguella,Isabel,
AU - Moraga,Fernando,
AU - Tarragó,David,
AU - Aguilera,Ulla,
AU - Casanovas,Josep M,
AU - Gadea,Gloria,
AU - Trías,Elisenda,
AU - Cenoz,Santiago,
AU - Sistiaga,Alessandra,
AU - García-Corbeira,Pilar,
AU - Pirçon,Jean-Yves,
AU - Marano,Cinzia,
AU - Hausdorff,William P,
Y1 - 2013/06/06/
PY - 2012/11/01/received
PY - 2013/04/02/revised
PY - 2013/04/06/accepted
PY - 2013/6/11/entrez
PY - 2013/6/12/pubmed
PY - 2014/3/29/medline
KW - Antibiotic resistance
KW - Haemophilus influenzae
KW - Otitis media
KW - Streptococcus pneumoniae
KW - Tympanocentesis
SP - 1231
EP - 6
JF - International journal of pediatric otorhinolaryngology
JO - Int J Pediatr Otorhinolaryngol
VL - 77
IS - 8
N2 - OBJECTIVE: To prospectively identify the bacterial aetiology and antimicrobial susceptibility of problematic (recurrent and treatment failure) acute otitis media in Spanish children several years after the introduction of 7-valent pneumococcal conjugate vaccine. METHODS: Tympanocentesis or careful sampling of spontaneous otorrhoea was performed on children aged 3 to <36 months with recurrent acute otitis media, acute otitis media treatment failure or unresolved acute otitis media. RESULTS: 105 acute otitis media episodes (77 sampled by tympanocentesis, 28 otorrhoea samples) were evaluated: 46 recurrent, 35 treatment failures, 24 unresolved acute otitis media. 74 episodes (70.4%) had at least one bacterium identified on culture: Streptococcus pneumoniae was identified in 21 episodes, Haemophilus influenzae (all non-typeable) in 44, Streptococcus pyogenes in 2, Moraxella catarrhalis in 2. No statistically significant difference in bacterial aetiology by episode type was detected. Non-typeable H. influenzae was the most commonly isolated pathogen in all acute otitis media types and in all age sub-groups. Forty percent of S. pneumoniae isolates were multi-drug resistant. Pneumococcal serotype 19A was the most frequently identified serotype (7/21 episodes). Multi-drug resistance was found in 56% of 19A isolates. Of non-typeable H. influenzae isolates, 15% were ampicillin resistant and 13% were amoxicillin/clavulanate resistant. S. pneumoniae and non-typeable H. influenzae DNA were each detected in 57% of samples culture negative for these pathogens, including 12 co-infections. CONCLUSION: Combining culture and polymerase chain reaction results, H. influenzae and S. pneumoniae may be implicated in 70% and 43% of clinically problematic bacterial acute otitis media episodes, respectively. The impact of new vaccines to prevent both S. pneumoniae and non-typeable H. influenzae acute otitis media may be substantial in this population and is worth investigating.
SN - 1872-8464
UR - https://www.unboundmedicine.com/medline/citation/23746414/Microbiology_of_bacteria_causing_recurrent_acute_otitis_media__AOM__and_AOM_treatment_failure_in_young_children_in_Spain:_shifting_pathogens_in_the_post_pneumococcal_conjugate_vaccination_era_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(13)00157-2
DB - PRIME
DP - Unbound Medicine
ER -