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Activation of the contact system in patients with a first acute myocardial infarction.
Thromb Res. 2013 Jul; 132(1):138-42.TR

Abstract

INTRODUCTION

The contribution of the contact system to arterial thrombosis is unclear, results of clinical studies are conflicting. Particularly, little is known about the involvement of the contact system in the progression of arterial thrombosis. Therefore, we investigated the activation of the contact system during an acute myocardial infarction (AMI) and 3 and 6 months following the acute event.

METHODS

Plasma of patients with a first AMI was collected on admission and 3 and 6 months after the AMI. The levels of complexes of activated factor XI (FXIa), FXIIa and kallikrein with C1 esterase inhibitor (C1INH) and the levels of complexes of FXIa with α1-antitrypsin (AT) were measured in these plasmas. Recurrent cardiovascular events were recorded during a one year period after the AMI.

RESULTS

We observed that the levels of FXIa-C1INH were elevated during the acute phase compared to the steady-phase 3 and 6 months after the AMI. The levels of FXIa-AT, FXIIa-C1INH and kallikrein-C1INH did not change over time. The levels of FXIa-C1INH, FXIa-AT, FXIIa-C1INH and kallikrein-C1INH were not predictive for a recurrent event.

CONCLUSION

We observed that during an AMI, the activation of FXI was increased. The levels of FXIIa-C1INH were not elevated, suggesting that activation of FXI during the acute phase did not result from contact activation. The levels of the enzyme inhibitor complexes were not predictive for a recurrent event one year after the first AMI.

Authors+Show Affiliations

Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands. J.Konings@maastrichtuniversity.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23746628

Citation

Konings, Joke, et al. "Activation of the Contact System in Patients With a First Acute Myocardial Infarction." Thrombosis Research, vol. 132, no. 1, 2013, pp. 138-42.
Konings J, Govers-Riemslag JW, Spronk HM, et al. Activation of the contact system in patients with a first acute myocardial infarction. Thromb Res. 2013;132(1):138-42.
Konings, J., Govers-Riemslag, J. W., Spronk, H. M., Waltenberger, J. L., & ten Cate, H. (2013). Activation of the contact system in patients with a first acute myocardial infarction. Thrombosis Research, 132(1), 138-42. https://doi.org/10.1016/j.thromres.2013.05.016
Konings J, et al. Activation of the Contact System in Patients With a First Acute Myocardial Infarction. Thromb Res. 2013;132(1):138-42. PubMed PMID: 23746628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of the contact system in patients with a first acute myocardial infarction. AU - Konings,Joke, AU - Govers-Riemslag,José W P, AU - Spronk,Henri M H, AU - Waltenberger,Johannes L, AU - ten Cate,Hugo, Y1 - 2013/06/07/ PY - 2013/02/07/received PY - 2013/04/12/revised PY - 2013/05/21/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/3/13/medline KW - A.U KW - AMI KW - Acute myocardial infarction KW - C1 esterase inhibitor KW - C1-esterase inhibitor KW - C1INH KW - CABG KW - CAD KW - CHD KW - CI KW - CV KW - Coagulation factor XI KW - Coagulation factor XII KW - Contact system KW - ELISA KW - F KW - F1.2 KW - IQR KW - LMWH KW - OR KW - PCI KW - Prekallikrein KW - SD KW - STI KW - acute myocardial infarction KW - arbitrary units KW - coagulation factor KW - coefficient variation KW - confidence interval KW - coronary artery bypass grafting KW - coronary artery disease KW - coronary heart disease KW - enzyme-linked immunosorbent assays KW - interquartile range KW - low-molecular-weight-heparin KW - odds ratio KW - percutaneous coronary intervention KW - prothrombin fragment 1.2 KW - soybean trypsin inhibitor KW - standard deviation SP - 138 EP - 42 JF - Thrombosis research JO - Thromb Res VL - 132 IS - 1 N2 - INTRODUCTION: The contribution of the contact system to arterial thrombosis is unclear, results of clinical studies are conflicting. Particularly, little is known about the involvement of the contact system in the progression of arterial thrombosis. Therefore, we investigated the activation of the contact system during an acute myocardial infarction (AMI) and 3 and 6 months following the acute event. METHODS: Plasma of patients with a first AMI was collected on admission and 3 and 6 months after the AMI. The levels of complexes of activated factor XI (FXIa), FXIIa and kallikrein with C1 esterase inhibitor (C1INH) and the levels of complexes of FXIa with α1-antitrypsin (AT) were measured in these plasmas. Recurrent cardiovascular events were recorded during a one year period after the AMI. RESULTS: We observed that the levels of FXIa-C1INH were elevated during the acute phase compared to the steady-phase 3 and 6 months after the AMI. The levels of FXIa-AT, FXIIa-C1INH and kallikrein-C1INH did not change over time. The levels of FXIa-C1INH, FXIa-AT, FXIIa-C1INH and kallikrein-C1INH were not predictive for a recurrent event. CONCLUSION: We observed that during an AMI, the activation of FXI was increased. The levels of FXIIa-C1INH were not elevated, suggesting that activation of FXI during the acute phase did not result from contact activation. The levels of the enzyme inhibitor complexes were not predictive for a recurrent event one year after the first AMI. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/23746628/Activation_of_the_contact_system_in_patients_with_a_first_acute_myocardial_infarction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(13)00208-9 DB - PRIME DP - Unbound Medicine ER -