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Effect of hypogammaglobulinemia on the incidence of community-acquired respiratory viral infections after lung transplantation.
Transplant Proc. 2013 Jul-Aug; 45(6):2371-4.TP

Abstract

BACKGROUND

Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality.

METHODS

A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of <700 mg/dL. CARVs included human metapneumovirus, influenza A/B, respiratory syncytial virus A/B, parainfluenza 1/2/3, rhinovirus, and adenovirus isolated from bronchoalveolar lavage/wash, sputum, or nasal swab.

RESULTS

The cohort consisted of 263 patients with a mean follow-up time of 612 ± 356 days. The incidence of CARV infection was 27% in patients with normal IgG titers and 23.4% in patients with HGG (P = .62). No difference in rejection, mortality, or lung function was found between the groups. As expected, patients who ever had a CARV infection had a significantly lower 1-second forced expiratory volume % reference on their most recent spirometry than those who had not had a CARV infection (81.6% vs 86.9%; P = .027).

CONCLUSIONS

Although CARV infection has been shown to affect lung graft function, these data suggests that HGG is not associated with the incidence of CARV infection.

Authors+Show Affiliations

Department of Pharmacy, The Methodist Hospital, Houston, Texas, USA. bcnoell@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23747186

Citation

Noell, B C., et al. "Effect of Hypogammaglobulinemia On the Incidence of Community-acquired Respiratory Viral Infections After Lung Transplantation." Transplantation Proceedings, vol. 45, no. 6, 2013, pp. 2371-4.
Noell BC, Dawson KL, Seethamraju H. Effect of hypogammaglobulinemia on the incidence of community-acquired respiratory viral infections after lung transplantation. Transplant Proc. 2013;45(6):2371-4.
Noell, B. C., Dawson, K. L., & Seethamraju, H. (2013). Effect of hypogammaglobulinemia on the incidence of community-acquired respiratory viral infections after lung transplantation. Transplantation Proceedings, 45(6), 2371-4. https://doi.org/10.1016/j.transproceed.2012.11.010
Noell BC, Dawson KL, Seethamraju H. Effect of Hypogammaglobulinemia On the Incidence of Community-acquired Respiratory Viral Infections After Lung Transplantation. Transplant Proc. 2013 Jul-Aug;45(6):2371-4. PubMed PMID: 23747186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hypogammaglobulinemia on the incidence of community-acquired respiratory viral infections after lung transplantation. AU - Noell,B C, AU - Dawson,K L, AU - Seethamraju,H, Y1 - 2013/06/06/ PY - 2012/10/26/received PY - 2012/11/27/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/4/29/medline SP - 2371 EP - 4 JF - Transplantation proceedings JO - Transplant. Proc. VL - 45 IS - 6 N2 - BACKGROUND: Hypogammaglobulinemia (HGG) has been associated with an increased risk of infectious complications in lung transplant recipients, but its effect specifically on community-acquired respiratory viruses (CARVs) remains unknown. This study aimed to determine if lung transplant recipients with HGG are at an increased risk of developing CARV infection. Secondary endpoints included the effect of HGG on lung function, incidence of rejection, and mortality. METHODS: A retrospective review of all lung transplant recipients from 2008 to 2011 was performed. Patients were stratified as either having HGG after transplantation or having normal IgG titers according to their nadir IgG level. HGG was defined a serum IgG level of <700 mg/dL. CARVs included human metapneumovirus, influenza A/B, respiratory syncytial virus A/B, parainfluenza 1/2/3, rhinovirus, and adenovirus isolated from bronchoalveolar lavage/wash, sputum, or nasal swab. RESULTS: The cohort consisted of 263 patients with a mean follow-up time of 612 ± 356 days. The incidence of CARV infection was 27% in patients with normal IgG titers and 23.4% in patients with HGG (P = .62). No difference in rejection, mortality, or lung function was found between the groups. As expected, patients who ever had a CARV infection had a significantly lower 1-second forced expiratory volume % reference on their most recent spirometry than those who had not had a CARV infection (81.6% vs 86.9%; P = .027). CONCLUSIONS: Although CARV infection has been shown to affect lung graft function, these data suggests that HGG is not associated with the incidence of CARV infection. SN - 1873-2623 UR - https://www.unboundmedicine.com/medline/citation/23747186/Effect_of_hypogammaglobulinemia_on_the_incidence_of_community_acquired_respiratory_viral_infections_after_lung_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(12)01316-4 DB - PRIME DP - Unbound Medicine ER -