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Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age.
Sci Total Environ. 2013 Sep 01; 461-462:386-90.ST

Abstract

BACKGROUND

Previous studies suggest that prenatal phthalate exposure affects neurodevelopment and behavior during the first years of life.

OBJECTIVES

To evaluate the effect of maternal urinary concentrations of phthalate metabolites during pregnancy on mental and psychomotor development in children 24-36 months of age.

METHODS

This analysis was conducted on the first three years of life among a subsample of 136 mother-child pairs from the ELEMENT cohort studies conducted in Mexico City. Maternal urine samples collected during the third trimester of pregnancy were analyzed for 9 phthalate metabolites: Mono-ethyl phthalate (MEP), Mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), mono-benzyl phthalate (MBzP), Mono-3-carboxypropyl phthalate (MCPP), and four di-2-ethylhexyl phthalate (DEHP) metabolites [mono-2-ethylhexyl-phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP)]. Among the 136 children, 135 (99.3%) completed the study period. Child neurodevelopment was assessed using mental and psychomotor development indexes (MDI and PDI) from a Bayley (BSID II) test at 24, 30, and 36 months of age. The effect of prenatal phthalate exposure on neurodevelopment was estimated using linear regression models for longitudinal data clustered at the individual level.

RESULTS

No significant associations were observed among all children combined, but differential effects by gender were found. Among girls, there was a negative association between MDI and DEHP metabolites MEHP (β=-2.11 [95% CI: -3.73, -0.49]), MEHHP (β=-1.89 [95% CI: -3.64, -0.15]), MEOHP (β=-1.80 [95% CI: -3.58, -0.03]) MECPP (β=-2.52 [95% CI: -4.44, -0.61]), and ΣDEHP (β=-3.41 [95% CI: -5.26, -1.55]); there was no significant effect among boys. Male PDI was positively related to MBzP (β=1.79 [95% CI: 0.14, 3.45]) and MCPP (β=1.64 [95% CI: 0.15, 3.12]); there was no significant effect on PDI among girls.

CONCLUSION

This study demonstrates that sex plays a role of an effect modifier in the association between prenatal phthalate exposure and neurodevelopment.

Authors+Show Affiliations

Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23747553

Citation

Téllez-Rojo, Martha M., et al. "Prenatal Urinary Phthalate Metabolites Levels and Neurodevelopment in Children at Two and Three Years of Age." The Science of the Total Environment, vol. 461-462, 2013, pp. 386-90.
Téllez-Rojo MM, Cantoral A, Cantonwine DE, et al. Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age. Sci Total Environ. 2013;461-462:386-90.
Téllez-Rojo, M. M., Cantoral, A., Cantonwine, D. E., Schnaas, L., Peterson, K., Hu, H., & Meeker, J. D. (2013). Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age. The Science of the Total Environment, 461-462, 386-90. https://doi.org/10.1016/j.scitotenv.2013.05.021
Téllez-Rojo MM, et al. Prenatal Urinary Phthalate Metabolites Levels and Neurodevelopment in Children at Two and Three Years of Age. Sci Total Environ. 2013 Sep 1;461-462:386-90. PubMed PMID: 23747553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age. AU - Téllez-Rojo,Martha M, AU - Cantoral,Alejandra, AU - Cantonwine,David E, AU - Schnaas,Lourdes, AU - Peterson,Karen, AU - Hu,Howard, AU - Meeker,John D, Y1 - 2013/06/05/ PY - 2013/01/09/received PY - 2013/05/08/revised PY - 2013/05/09/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/3/7/medline KW - BSID II KW - Biomarkers KW - CDC KW - CI KW - Centers for Disease Control and Prevention KW - Child development KW - DEHP KW - HMWP KW - LMWP KW - LOD KW - Longitudinal study KW - MBzP KW - MCPP KW - MDI KW - MECPP KW - MEHHP KW - MEHP KW - MEOHP KW - MEP KW - Mental Development Index KW - MiBP KW - MnBP KW - Mono-(3-carboxypropyl) phthalate KW - Mono-ethyl phthalate KW - Mono-n-butyl phthalate KW - PDI KW - Phthalates KW - Prenatal exposure KW - Psychomotor Development Index KW - SG KW - confidence interval KW - di-2-ethylhexyl phthalate KW - high molecular weight phthalates KW - limit of detection KW - low molecular weight phthalates KW - mono-(2-ethyl-5-carboxypentyl) phthalate KW - mono-(2-ethyl-5-hydroxyhexyl) phthalate KW - mono-(2-ethyl-5-oxohexyl) phthalate KW - mono-2-ethylhexyl phthalate KW - mono-benzyl phthalate KW - mono-isobutyl phthalate KW - specific gravity KW - sum of di-2-ethylhexyl phthalate metabolites KW - the Bayley Scales of Infant Development II KW - ΣDEHP SP - 386 EP - 90 JF - The Science of the total environment JO - Sci Total Environ VL - 461-462 N2 - BACKGROUND: Previous studies suggest that prenatal phthalate exposure affects neurodevelopment and behavior during the first years of life. OBJECTIVES: To evaluate the effect of maternal urinary concentrations of phthalate metabolites during pregnancy on mental and psychomotor development in children 24-36 months of age. METHODS: This analysis was conducted on the first three years of life among a subsample of 136 mother-child pairs from the ELEMENT cohort studies conducted in Mexico City. Maternal urine samples collected during the third trimester of pregnancy were analyzed for 9 phthalate metabolites: Mono-ethyl phthalate (MEP), Mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), mono-benzyl phthalate (MBzP), Mono-3-carboxypropyl phthalate (MCPP), and four di-2-ethylhexyl phthalate (DEHP) metabolites [mono-2-ethylhexyl-phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP)]. Among the 136 children, 135 (99.3%) completed the study period. Child neurodevelopment was assessed using mental and psychomotor development indexes (MDI and PDI) from a Bayley (BSID II) test at 24, 30, and 36 months of age. The effect of prenatal phthalate exposure on neurodevelopment was estimated using linear regression models for longitudinal data clustered at the individual level. RESULTS: No significant associations were observed among all children combined, but differential effects by gender were found. Among girls, there was a negative association between MDI and DEHP metabolites MEHP (β=-2.11 [95% CI: -3.73, -0.49]), MEHHP (β=-1.89 [95% CI: -3.64, -0.15]), MEOHP (β=-1.80 [95% CI: -3.58, -0.03]) MECPP (β=-2.52 [95% CI: -4.44, -0.61]), and ΣDEHP (β=-3.41 [95% CI: -5.26, -1.55]); there was no significant effect among boys. Male PDI was positively related to MBzP (β=1.79 [95% CI: 0.14, 3.45]) and MCPP (β=1.64 [95% CI: 0.15, 3.12]); there was no significant effect on PDI among girls. CONCLUSION: This study demonstrates that sex plays a role of an effect modifier in the association between prenatal phthalate exposure and neurodevelopment. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/23747553/Prenatal_urinary_phthalate_metabolites_levels_and_neurodevelopment_in_children_at_two_and_three_years_of_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(13)00564-0 DB - PRIME DP - Unbound Medicine ER -