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Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity.
J Ethnopharmacol. 2013 Aug 26; 149(1):1-23.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The aerial parts of Senecio scandens Buch.-Ham. (family Asteraceae) have a long history in traditional Chinese medicine as a treatment for various ailments, such as bacterial diarrhea, enteritis, conjunctivitis, and respiratory tract infections.

MATERIALS AND METHODS

A bibliographic investigation of Senecio scandens was accomplished by analyzing secondary sources, including the Chinese Medicinal plantal Classics, the Internet (Google Scholar and Baidu Scholar), and scientific databases accepted worldwide (Pubmed, Scopus, Web of Science, SciFinder, and CNKI). These sources were scrutinized for available information about the uses of Senecio scandens in traditional Chinese medicine, phytochemistry, pharmacology, and toxicology.

RESULTS

Senecio scandens is a medicinal plant with a climbing woody stem. Phytochemical studies have shown the presence of numerous valuable compounds, such as flavonoids, alkaloids, phenolic acids, terpenes, volatile oils, carotenoids, and trace elements. Among them, PAs are the characteristic constituents, adonifoline is one of the index ingredients of Senecio scandens. Studies in modern pharmacology have demonstrated that extracts and compounds isolated from Senecio scandens show a wide spectrum of pharmacological activities, including anti-inflammatory, antimicrobial, anti-leptospirosis, hepatoprotective, anti-infusorial, antioxidant, antiviral, antitumoral, analgesic, mutagenic, and toxicological activities.

CONCLUSIONS

Phytochemical and pharmacological studies have demonstrated that the extracts of the plant possess various pharmacological activities that can be attributed to the presence of various flavonoids, phenolic acids, and alkaloids. Newer technologies for qualitative and quantitative methods of PAs need to be developed to obtain better accuracy and sensitivity. Due to the toxicity of PAs present in this medicinal plant, the regulations on PAs of Senecio scandens were varied among different countries and regions. In China, the PAs toxicity of Senecio scandens ranking criteria is not well defined in the Chinese Pharmacopoeia 2010, and there is no strict uniform requirement on the PAs in western countries. We propose that the use of Senecio scandens should be reevaluated based on a set of criteria, which includes risk-benefit analysis and severity of the toxic effects, clinical and preclinical data to ensure safe use while continuing to satisfy the need for access to the medicinal plant.

Authors+Show Affiliations

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23747644

Citation

Wang, Dongmei, et al. "Senecio Scandens Buch.-Ham.: a Review On Its Ethnopharmacology, Phytochemistry, Pharmacology, and Toxicity." Journal of Ethnopharmacology, vol. 149, no. 1, 2013, pp. 1-23.
Wang D, Huang L, Chen S. Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity. J Ethnopharmacol. 2013;149(1):1-23.
Wang, D., Huang, L., & Chen, S. (2013). Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity. Journal of Ethnopharmacology, 149(1), 1-23. https://doi.org/10.1016/j.jep.2013.05.048
Wang D, Huang L, Chen S. Senecio Scandens Buch.-Ham.: a Review On Its Ethnopharmacology, Phytochemistry, Pharmacology, and Toxicity. J Ethnopharmacol. 2013 Aug 26;149(1):1-23. PubMed PMID: 23747644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity. AU - Wang,Dongmei, AU - Huang,Linfang, AU - Chen,Shilin, Y1 - 2013/06/07/ PY - 2013/01/11/received PY - 2013/05/20/revised PY - 2013/05/21/accepted PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2014/3/29/medline KW - Alkaloids KW - CP 2010 KW - CPPR KW - Chinese Pharmacopoiea 2010 KW - Flavonoids KW - GC–MS KW - HPAs KW - HPLC KW - HPLC–MS KW - LC–MS KW - LD(50) KW - MIC KW - NMR KW - OPLS-DA KW - OTC KW - PANO KW - PAs KW - PCA KW - PGE2 KW - PIS KW - Pharmacology KW - Phytochemistry KW - RSV KW - SCE KW - SD KW - Senecio scandens KW - Senecio scandens Buch.-Ham. KW - Senecio scandens extract KW - Sprague-Dawley rats KW - TCM KW - TLC KW - The Committee of Pharmacopeia of the People's Republic of China KW - Toxicology KW - WHO KW - World Health Organization KW - gas chromatography–mass spectrometry KW - hepatotoxic pyrrolizidine alkaloids KW - high-performance liquid chromatography KW - high-performance liquid chromatography–mass spectrometry KW - liquid chromatography–mass spectrometry KW - minimal inhibitory concentration KW - nuclear magnetic resonance KW - orthogonal projections to latent structures-discriminant analysis KW - over-the-counter KW - precursor ion scan KW - principle component analysis KW - prostaglandin E2 KW - pyrrolizidine alkaloids KW - pyrrolizidine alkaloids N-oxide KW - respiratory syncytial virus KW - the median lethal dose for 50% of the tested subjects KW - thin-layer chromatography KW - traditional Chinese medicine SP - 1 EP - 23 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 149 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Senecio scandens Buch.-Ham. (family Asteraceae) have a long history in traditional Chinese medicine as a treatment for various ailments, such as bacterial diarrhea, enteritis, conjunctivitis, and respiratory tract infections. MATERIALS AND METHODS: A bibliographic investigation of Senecio scandens was accomplished by analyzing secondary sources, including the Chinese Medicinal plantal Classics, the Internet (Google Scholar and Baidu Scholar), and scientific databases accepted worldwide (Pubmed, Scopus, Web of Science, SciFinder, and CNKI). These sources were scrutinized for available information about the uses of Senecio scandens in traditional Chinese medicine, phytochemistry, pharmacology, and toxicology. RESULTS: Senecio scandens is a medicinal plant with a climbing woody stem. Phytochemical studies have shown the presence of numerous valuable compounds, such as flavonoids, alkaloids, phenolic acids, terpenes, volatile oils, carotenoids, and trace elements. Among them, PAs are the characteristic constituents, adonifoline is one of the index ingredients of Senecio scandens. Studies in modern pharmacology have demonstrated that extracts and compounds isolated from Senecio scandens show a wide spectrum of pharmacological activities, including anti-inflammatory, antimicrobial, anti-leptospirosis, hepatoprotective, anti-infusorial, antioxidant, antiviral, antitumoral, analgesic, mutagenic, and toxicological activities. CONCLUSIONS: Phytochemical and pharmacological studies have demonstrated that the extracts of the plant possess various pharmacological activities that can be attributed to the presence of various flavonoids, phenolic acids, and alkaloids. Newer technologies for qualitative and quantitative methods of PAs need to be developed to obtain better accuracy and sensitivity. Due to the toxicity of PAs present in this medicinal plant, the regulations on PAs of Senecio scandens were varied among different countries and regions. In China, the PAs toxicity of Senecio scandens ranking criteria is not well defined in the Chinese Pharmacopoeia 2010, and there is no strict uniform requirement on the PAs in western countries. We propose that the use of Senecio scandens should be reevaluated based on a set of criteria, which includes risk-benefit analysis and severity of the toxic effects, clinical and preclinical data to ensure safe use while continuing to satisfy the need for access to the medicinal plant. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/23747644/Senecio_scandens_Buch__Ham_:_a_review_on_its_ethnopharmacology_phytochemistry_pharmacology_and_toxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(13)00399-1 DB - PRIME DP - Unbound Medicine ER -