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Serum pepsinogens and Helicobacter pylori are not associated with esophageal squamous cell carcinoma in a high-risk area in China.
Tumori. 2013 Mar-Apr; 99(2):134-8.T

Abstract

AIMS AND BACKGROUND

The role of serum pepsinogen level and Helicobacter pylori infection in esophageal carcinoma remains controversial. It may be a risk or protective factor, or without association with esophageal carcinoma. We prospectively examined associations between serum pepsinogen status, H pylori infection and the risk of esophageal squamous cell carcinoma in the Chinese population.

METHODS

In the present study, 1501 subjects from a community-based general population of Northern China were included. The incidence of esophageal carcinoma among the subjects was registered during a 15-year follow-up period by annual home visit, and the risks of low serum pepsinogen level and H pylori infection in the development of ESCC were evaluated using logistic regression.

RESULTS

The total accumulated incidence of ESCC in the cohort was 666/100,000 during the 15-year follow-up. Notably, all the cases were verified to be ESCC. Logistic regression analysis showed that age ≥60 (OR = 9.67; 95% CI, 2.797-33.423) was the only risk factor for esophageal squamous cell carcinoma in the population. There was no significant association between sex, H pylori infection, pepsinogen level (PG I ≤70 ng/ml alone, PG I/II ratio ≤3 alone, or PG I ≤70 ng/ml and PG I/II ratio ≤3) and esophageal squamous cell carcinoma.

CONCLUSIONS

In this prospective study, neither H pylori infection nor abnormal pepsinogen status had a predictive role for the development of esophageal squamous cell carcinoma in the rural population of China.

Authors+Show Affiliations

Department of Pathology, Hebei Medical University, Shijiazhuang, Hebei, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23748803

Citation

Xue, Liying, et al. "Serum Pepsinogens and Helicobacter Pylori Are Not Associated With Esophageal Squamous Cell Carcinoma in a High-risk Area in China." Tumori, vol. 99, no. 2, 2013, pp. 134-8.
Xue L, Xing L, Wang J, et al. Serum pepsinogens and Helicobacter pylori are not associated with esophageal squamous cell carcinoma in a high-risk area in China. Tumori. 2013;99(2):134-8.
Xue, L., Xing, L., Wang, J., Shen, H., Cui, J., Mi, J., Wang, J., Misumi, J., & Zhang, X. (2013). Serum pepsinogens and Helicobacter pylori are not associated with esophageal squamous cell carcinoma in a high-risk area in China. Tumori, 99(2), 134-8. https://doi.org/10.1700/1283.14181
Xue L, et al. Serum Pepsinogens and Helicobacter Pylori Are Not Associated With Esophageal Squamous Cell Carcinoma in a High-risk Area in China. Tumori. 2013 Mar-Apr;99(2):134-8. PubMed PMID: 23748803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum pepsinogens and Helicobacter pylori are not associated with esophageal squamous cell carcinoma in a high-risk area in China. AU - Xue,Liying, AU - Xing,Lingxiao, AU - Wang,Junling, AU - Shen,Haitao, AU - Cui,Jinfeng, AU - Mi,Jianmin, AU - Wang,Juan, AU - Misumi,Junichi, AU - Zhang,Xianghong, PY - 2013/6/11/entrez PY - 2013/6/12/pubmed PY - 2013/8/10/medline SP - 134 EP - 8 JF - Tumori JO - Tumori VL - 99 IS - 2 N2 - AIMS AND BACKGROUND: The role of serum pepsinogen level and Helicobacter pylori infection in esophageal carcinoma remains controversial. It may be a risk or protective factor, or without association with esophageal carcinoma. We prospectively examined associations between serum pepsinogen status, H pylori infection and the risk of esophageal squamous cell carcinoma in the Chinese population. METHODS: In the present study, 1501 subjects from a community-based general population of Northern China were included. The incidence of esophageal carcinoma among the subjects was registered during a 15-year follow-up period by annual home visit, and the risks of low serum pepsinogen level and H pylori infection in the development of ESCC were evaluated using logistic regression. RESULTS: The total accumulated incidence of ESCC in the cohort was 666/100,000 during the 15-year follow-up. Notably, all the cases were verified to be ESCC. Logistic regression analysis showed that age ≥60 (OR = 9.67; 95% CI, 2.797-33.423) was the only risk factor for esophageal squamous cell carcinoma in the population. There was no significant association between sex, H pylori infection, pepsinogen level (PG I ≤70 ng/ml alone, PG I/II ratio ≤3 alone, or PG I ≤70 ng/ml and PG I/II ratio ≤3) and esophageal squamous cell carcinoma. CONCLUSIONS: In this prospective study, neither H pylori infection nor abnormal pepsinogen status had a predictive role for the development of esophageal squamous cell carcinoma in the rural population of China. SN - 2038-2529 UR - https://www.unboundmedicine.com/medline/citation/23748803/Serum_pepsinogens_and_Helicobacter_pylori_are_not_associated_with_esophageal_squamous_cell_carcinoma_in_a_high_risk_area_in_China_ L2 - https://journals.sagepub.com/doi/10.1700/1283.14181?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -