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Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides.
J Org Chem. 2013 Jun 21; 78(12):6163-9.JO

Abstract

A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

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Authors+Show Affiliations

Yu YY
Department of Chemistry, the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
Bi L
No affiliation info available
Georg GI
No affiliation info available

MeSH

CatalysisCyclizationIodineMolecular StructurePalladiumPiperidinesPyridonesStereoisomerism

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23750615

Citation

Yu, Yi-Yun, et al. "Palladium-catalyzed Direct C-H Arylation of Cyclic Enaminones With Aryl Iodides." The Journal of Organic Chemistry, vol. 78, no. 12, 2013, pp. 6163-9.
Yu YY, Bi L, Georg GI. Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. J Org Chem. 2013;78(12):6163-9.
Yu, Y. Y., Bi, L., & Georg, G. I. (2013). Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. The Journal of Organic Chemistry, 78(12), 6163-9. https://doi.org/10.1021/jo400830t
Yu YY, Bi L, Georg GI. Palladium-catalyzed Direct C-H Arylation of Cyclic Enaminones With Aryl Iodides. J Org Chem. 2013 Jun 21;78(12):6163-9. PubMed PMID: 23750615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium-catalyzed direct C-H arylation of cyclic enaminones with aryl iodides. AU - Yu,Yi-Yun, AU - Bi,Lei, AU - Georg,Gunda I, Y1 - 2013/06/10/ PY - 2013/6/12/entrez PY - 2013/6/12/pubmed PY - 2014/1/17/medline SP - 6163 EP - 9 JF - The Journal of organic chemistry JO - J Org Chem VL - 78 IS - 12 N2 - A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs. SN - 1520-6904 UR - https://www.unboundmedicine.com/medline/citation/23750615/Palladium_catalyzed_direct_C_H_arylation_of_cyclic_enaminones_with_aryl_iodides_ L2 - https://doi.org/10.1021/jo400830t DB - PRIME DP - Unbound Medicine ER -