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Early prenatal diagnosis of orofacial clefts: evaluation of the retronasal triangle using a new three-dimensional reslicing technique.
Fetal Diagn Ther. 2013; 34(1):31-7.FD

Abstract

BACKGROUND

The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increasing in recent time.

MATERIALS AND METHODS

We obtained three-dimensional data sets of the fetal face from 100 low-risk and 50 high-risk first-trimester fetuses to evaluate the offline reformatting accuracy of the retronasal triangle (RNT) using a novel reslicing technique.

RESULTS

Adequate volume data sets for offline analysis were captured in 98% of cases. The RNT view was reformatted in 96% of cases by offline analysis. The secondary palate could be assessed in 93% by offline analysis and an abnormal RNT in the coronal plane was detected in 2 cases of lethal aneuploidy. The false-positive rate was 1.33% in the two studied groups.

CONCLUSION

Abnormal RNT seems to be a valuable ultrasound marker for the early diagnosis of facial clefting. This novel reslicing technique has proven to be easy, fast and accurate, which suggest that this technology could be included in daily practice and integrated with other applications such as multiplanar mode and volume NT. Prospective studies are needed to confirm these promising results and to demonstrate if these diagnostic armamentarium tools will lead to a diagnostic enhancement of cleft lip and palate in early pregnancy.

Authors+Show Affiliations

Prenatal Diagnostic Unit, Division of Obstetrics and Gynecology, Guastalla Civil Hospital, AUSL Reggio Emilia, Italy. Tonni.Gabriele@ausl.re.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

23751354

Citation

Tonni, Gabriele, et al. "Early Prenatal Diagnosis of Orofacial Clefts: Evaluation of the Retronasal Triangle Using a New Three-dimensional Reslicing Technique." Fetal Diagnosis and Therapy, vol. 34, no. 1, 2013, pp. 31-7.
Tonni G, Grisolia G, Sepulveda W. Early prenatal diagnosis of orofacial clefts: evaluation of the retronasal triangle using a new three-dimensional reslicing technique. Fetal Diagn Ther. 2013;34(1):31-7.
Tonni, G., Grisolia, G., & Sepulveda, W. (2013). Early prenatal diagnosis of orofacial clefts: evaluation of the retronasal triangle using a new three-dimensional reslicing technique. Fetal Diagnosis and Therapy, 34(1), 31-7. https://doi.org/10.1159/000350181
Tonni G, Grisolia G, Sepulveda W. Early Prenatal Diagnosis of Orofacial Clefts: Evaluation of the Retronasal Triangle Using a New Three-dimensional Reslicing Technique. Fetal Diagn Ther. 2013;34(1):31-7. PubMed PMID: 23751354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early prenatal diagnosis of orofacial clefts: evaluation of the retronasal triangle using a new three-dimensional reslicing technique. AU - Tonni,Gabriele, AU - Grisolia,Gianpaolo, AU - Sepulveda,Waldo, Y1 - 2013/06/06/ PY - 2012/11/10/received PY - 2013/02/14/accepted PY - 2013/6/12/entrez PY - 2013/6/12/pubmed PY - 2014/3/7/medline SP - 31 EP - 7 JF - Fetal diagnosis and therapy JO - Fetal Diagn Ther VL - 34 IS - 1 N2 - BACKGROUND: The role of three-dimensional ultrasound in the prenatal diagnosis of orofacial clefts is increasing in recent time. MATERIALS AND METHODS: We obtained three-dimensional data sets of the fetal face from 100 low-risk and 50 high-risk first-trimester fetuses to evaluate the offline reformatting accuracy of the retronasal triangle (RNT) using a novel reslicing technique. RESULTS: Adequate volume data sets for offline analysis were captured in 98% of cases. The RNT view was reformatted in 96% of cases by offline analysis. The secondary palate could be assessed in 93% by offline analysis and an abnormal RNT in the coronal plane was detected in 2 cases of lethal aneuploidy. The false-positive rate was 1.33% in the two studied groups. CONCLUSION: Abnormal RNT seems to be a valuable ultrasound marker for the early diagnosis of facial clefting. This novel reslicing technique has proven to be easy, fast and accurate, which suggest that this technology could be included in daily practice and integrated with other applications such as multiplanar mode and volume NT. Prospective studies are needed to confirm these promising results and to demonstrate if these diagnostic armamentarium tools will lead to a diagnostic enhancement of cleft lip and palate in early pregnancy. SN - 1421-9964 UR - https://www.unboundmedicine.com/medline/citation/23751354/Early_prenatal_diagnosis_of_orofacial_clefts:_evaluation_of_the_retronasal_triangle_using_a_new_three_dimensional_reslicing_technique_ L2 - https://www.karger.com?DOI=10.1159/000350181 DB - PRIME DP - Unbound Medicine ER -