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Nevirapine induces testicular toxicity in Wistar rats: reversal effect of kolaviron (biflavonoid from Garcinia kola seeds).
J Basic Clin Physiol Pharmacol. 2013; 24(4):313-20.JB

Abstract

BACKGROUND

Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV infections and has been reported to be toxic to the male reproductive system. This study was designed to evaluate the ameliorative effects of kolaviron (KV), a biflavonoid from Garcinia kola, on NVP-induced testicular toxicity.

METHODS

The adult male Wistar rats were given two and four times therapeutic doses of NVP (NVP-2T and NVP-4T; 18 and 36 mg/kg NVP) alone or in combination with KV (200 mg/kg). NVP was given daily, whereas KV was administered five times in a week by oral gavage.

RESULTS

Treatment with NVP did not alter the body weight gain and relative weight of testis of the rats. NVP-4T significantly (p<0.05) decreased the sperm motility, protein content, and live-dead ratio and also increased the percentage sperm abnormalities of the rats. Although NVP-4T significantly increased sperm abnormalities, it has no effect on epididymal sperm count. Also, NVP-4T caused a significant (p<0.05) elevation of serum aminotransferases and γ-glutamyl transferase activities. In addition, NVP-4T significantly (p<0.05) decreased the levels of testicular superoxide dismutase, catalase, glutathione S-transferase, and glutathione with marked elevation of malondialdehyde (index of lipid peroxidation) in the rats. In contrast, NVP-2T did not produce an adverse effect on the biochemical indices studied in testes and sperm of rats. Supplementation with KV significantly ameliorated the biochemical changes caused by NVP-4T.

CONCLUSIONS

Taken together, KV reversed the adverse effects of NVP-4T on testicular antioxidant enzymes and markers of oxidative stress in the rats.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23751390

Citation

Adaramoye, Oluwatosin A., et al. "Nevirapine Induces Testicular Toxicity in Wistar Rats: Reversal Effect of Kolaviron (biflavonoid From Garcinia Kola Seeds)." Journal of Basic and Clinical Physiology and Pharmacology, vol. 24, no. 4, 2013, pp. 313-20.
Adaramoye OA, Akanni OO, Farombi EO. Nevirapine induces testicular toxicity in Wistar rats: reversal effect of kolaviron (biflavonoid from Garcinia kola seeds). J Basic Clin Physiol Pharmacol. 2013;24(4):313-20.
Adaramoye, O. A., Akanni, O. O., & Farombi, E. O. (2013). Nevirapine induces testicular toxicity in Wistar rats: reversal effect of kolaviron (biflavonoid from Garcinia kola seeds). Journal of Basic and Clinical Physiology and Pharmacology, 24(4), 313-20. https://doi.org/10.1515/jbcpp-2012-0078
Adaramoye OA, Akanni OO, Farombi EO. Nevirapine Induces Testicular Toxicity in Wistar Rats: Reversal Effect of Kolaviron (biflavonoid From Garcinia Kola Seeds). J Basic Clin Physiol Pharmacol. 2013;24(4):313-20. PubMed PMID: 23751390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nevirapine induces testicular toxicity in Wistar rats: reversal effect of kolaviron (biflavonoid from Garcinia kola seeds). AU - Adaramoye,Oluwatosin A, AU - Akanni,Olubukola O, AU - Farombi,Ebenezer O, PY - 2012/12/18/received PY - 2013/04/26/accepted PY - 2013/6/12/entrez PY - 2013/6/12/pubmed PY - 2014/6/26/medline SP - 313 EP - 20 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 24 IS - 4 N2 - BACKGROUND: Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV infections and has been reported to be toxic to the male reproductive system. This study was designed to evaluate the ameliorative effects of kolaviron (KV), a biflavonoid from Garcinia kola, on NVP-induced testicular toxicity. METHODS: The adult male Wistar rats were given two and four times therapeutic doses of NVP (NVP-2T and NVP-4T; 18 and 36 mg/kg NVP) alone or in combination with KV (200 mg/kg). NVP was given daily, whereas KV was administered five times in a week by oral gavage. RESULTS: Treatment with NVP did not alter the body weight gain and relative weight of testis of the rats. NVP-4T significantly (p<0.05) decreased the sperm motility, protein content, and live-dead ratio and also increased the percentage sperm abnormalities of the rats. Although NVP-4T significantly increased sperm abnormalities, it has no effect on epididymal sperm count. Also, NVP-4T caused a significant (p<0.05) elevation of serum aminotransferases and γ-glutamyl transferase activities. In addition, NVP-4T significantly (p<0.05) decreased the levels of testicular superoxide dismutase, catalase, glutathione S-transferase, and glutathione with marked elevation of malondialdehyde (index of lipid peroxidation) in the rats. In contrast, NVP-2T did not produce an adverse effect on the biochemical indices studied in testes and sperm of rats. Supplementation with KV significantly ameliorated the biochemical changes caused by NVP-4T. CONCLUSIONS: Taken together, KV reversed the adverse effects of NVP-4T on testicular antioxidant enzymes and markers of oxidative stress in the rats. SN - 2191-0286 UR - https://www.unboundmedicine.com/medline/citation/23751390/Nevirapine_induces_testicular_toxicity_in_Wistar_rats:_reversal_effect_of_kolaviron__biflavonoid_from_Garcinia_kola_seeds__ L2 - https://www.degruyter.com/document/doi/10.1515/jbcpp-2012-0078 DB - PRIME DP - Unbound Medicine ER -