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Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients.
Int J Cardiovasc Imaging. 2013 Jun; 29 Suppl 1:29-36.IJ

Abstract

The aims of this study were: (a) to assess clinical predictors and coronary computed tomography angiography (CCTA) characteristics of noncalcified coronary plaques (NCP) in subjects who had cardiac events despite a zero coronary artery calcium score (CACS), and (b) to describe computed tomography (CT) plaque characteristics in subjects with cardiac events. A total of 7,961 subjects with zero CACS were evaluated; 6,531 subjects underwent CCTA as part of a health check-up. Those who had zero CACS were included in our mid-term follow-up study. Cardiac events included cardiac death, acute coronary syndrome or revascularization with stable angina. More than one NCP was identified in 441 subjects with zero CACS, including 48 subjects with obstructive coronary artery disease (CAD) caused by NCPs. Age, male gender, hypertension, diabetes and low density lipoprotein were independent predictors of obstructive CAD. Among subjects with obstructive CAD, young adults were classified into low (79.2 %) or moderate (72.9 %) risk groups by the National Centers for Environmental Prediction III guidelines. Approximately 0.2 % of subjects had cardiac events during our follow-up period. All patients with cardiac events had NCPs with significantly lower mean CT numbers, higher remodeling indexes and worse degree of stenosis. In asymptomatic subjects with zero CACS, NCP was associated with cardiac events. CCTA might be useful for risk stratification among select populations with CAD and zero CACS who have certain plaque characteristics associated with cardiac events.

Authors+Show Affiliations

Division of Cardiovascular Imaging, Department of Radiology, Seoul National University Bundang Hospital, 300 Gumi-dong, Bungdang-gu, Seongnam-si, Gyeonggi-do 436-707, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23754773

Citation

Lee, Min Su, et al. "Asymptomatic Subjects With Zero Coronary Calcium Score: Coronary CT Angiographic Features of Plaques in Event-prone Patients." The International Journal of Cardiovascular Imaging, vol. 29 Suppl 1, 2013, pp. 29-36.
Lee MS, Chun EJ, Kim KJ, et al. Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients. Int J Cardiovasc Imaging. 2013;29 Suppl 1:29-36.
Lee, M. S., Chun, E. J., Kim, K. J., Kim, J. A., Yoo, J. Y., & Choi, S. I. (2013). Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients. The International Journal of Cardiovascular Imaging, 29 Suppl 1, 29-36. https://doi.org/10.1007/s10554-013-0257-z
Lee MS, et al. Asymptomatic Subjects With Zero Coronary Calcium Score: Coronary CT Angiographic Features of Plaques in Event-prone Patients. Int J Cardiovasc Imaging. 2013;29 Suppl 1:29-36. PubMed PMID: 23754773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients. AU - Lee,Min Su, AU - Chun,Eun Ju, AU - Kim,Kil Joong, AU - Kim,Jeong A, AU - Yoo,Jin Young, AU - Choi,Sang Il, Y1 - 2013/06/11/ PY - 2013/05/24/received PY - 2013/06/05/accepted PY - 2013/6/12/entrez PY - 2013/6/12/pubmed PY - 2014/2/22/medline SP - 29 EP - 36 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 29 Suppl 1 N2 - The aims of this study were: (a) to assess clinical predictors and coronary computed tomography angiography (CCTA) characteristics of noncalcified coronary plaques (NCP) in subjects who had cardiac events despite a zero coronary artery calcium score (CACS), and (b) to describe computed tomography (CT) plaque characteristics in subjects with cardiac events. A total of 7,961 subjects with zero CACS were evaluated; 6,531 subjects underwent CCTA as part of a health check-up. Those who had zero CACS were included in our mid-term follow-up study. Cardiac events included cardiac death, acute coronary syndrome or revascularization with stable angina. More than one NCP was identified in 441 subjects with zero CACS, including 48 subjects with obstructive coronary artery disease (CAD) caused by NCPs. Age, male gender, hypertension, diabetes and low density lipoprotein were independent predictors of obstructive CAD. Among subjects with obstructive CAD, young adults were classified into low (79.2 %) or moderate (72.9 %) risk groups by the National Centers for Environmental Prediction III guidelines. Approximately 0.2 % of subjects had cardiac events during our follow-up period. All patients with cardiac events had NCPs with significantly lower mean CT numbers, higher remodeling indexes and worse degree of stenosis. In asymptomatic subjects with zero CACS, NCP was associated with cardiac events. CCTA might be useful for risk stratification among select populations with CAD and zero CACS who have certain plaque characteristics associated with cardiac events. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/23754773/Asymptomatic_subjects_with_zero_coronary_calcium_score:_coronary_CT_angiographic_features_of_plaques_in_event_prone_patients_ L2 - https://doi.org/10.1007/s10554-013-0257-z DB - PRIME DP - Unbound Medicine ER -