TY - JOUR T1 - Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases. AU - Wu,Ping, AU - Zuo,Xialin, AU - Deng,Houliang, AU - Liu,Xiaoxia, AU - Liu,Li, AU - Ji,Aimin, Y1 - 2013/06/10/ PY - 2013/02/25/received PY - 2013/05/31/revised PY - 2013/06/01/accepted PY - 2013/6/13/entrez PY - 2013/6/13/pubmed PY - 2014/3/19/medline KW - 5′-bromo-uridine immunoprecipitation chase followed by deep sequencing KW - AD KW - ALS KW - APP KW - Alzheimer's disease KW - Aβ40 KW - Aβ42 KW - BACE1 KW - BC1 KW - BC200 (BCYRN1) KW - BDNF KW - BRIC–Seq KW - CHIRP-Seq KW - CNS KW - Ca(2+)/calmodulin-dependent protein kinase II KW - CaMKII KW - Camk2n1 KW - DJ-1 (PARK7) KW - DNA-binding domain protein 43 KW - ENORs KW - Expression signature KW - FUS/TLS KW - GDNFOS KW - Gad1 KW - Gene Nomenclature Committee KW - HAR1 KW - HD KW - HGNCHOTAIRM1 KW - HOX antisense intergenic RNA myeloid 1 KW - HTTAS KW - HUGO KW - Huntingtin antisense KW - Huntington's disease KW - ISH KW - LRRK2 KW - LTD KW - LTP KW - Malat1 KW - NAT-Rad18 KW - NO KW - NOSs KW - NTAs KW - Neurodegenerative disease KW - Neuron KW - Nitric oxide KW - Nkx2.2 AS KW - Nkx2.2 antisense KW - Noncoding RNA KW - Nrgn KW - ORF KW - PCG KW - PD KW - PINK1 KW - PRC2 KW - Parkinson disease protein 7 KW - Parkinson's disease KW - RE1-silencing transcription factor/neuron-restrictive silencer factor KW - REST/NRSF KW - RIP-Chip KW - RNCR2 KW - RNP immunoprecipitation-microarray KW - SAGE KW - SOX2 KW - SRY (sex determining region Y)-box 2 KW - Shh KW - Six3 opposite strand KW - Six3OS KW - Sox2 overlapping transcript KW - Sox2OT KW - TDP43TAR KW - TUG1 KW - X-inactive specific transcript KW - Xist KW - amyloid precursor protein KW - amyloid-β-40 KW - amyloid-β-42 KW - amyotrophic lateral sclerosis KW - brain cytoplasmic RNA 1 KW - brain derived neurotrophic factor KW - c-KLAN KW - calcium/calmodulin-dependent protein kinase II inhibitor 1 KW - catRAPID KW - central nervous system KW - chromatin isolation by RNA purification followed by deep sequencing KW - combined knockdown and localization analysis of noncoding RNAs KW - eIF4A KW - eukaryotic initiation factor 4A KW - expressed noncoding regions KW - fast predictions of RNA and protein interactions and domains KW - fused in sarcoma/translated in liposarcoma KW - glial cell derived neurotrophic factor opposite strand KW - glutamate decarboxylase 1 KW - human accelerated regions 1 KW - iPSC KW - in situ hybridization KW - induced pluripotent stem cells KW - large intergenic noncoding RNAs KW - leucine-rich repeat kinase 2 KW - lincRNAs KW - lncRNA KW - lncRNAs KW - long noncoding RNAs KW - long-term depression KW - long-term potentiation KW - metastasis-associated lung adenocarcinoma transcript 1 KW - natural antisense RNAs KW - natural antisense-Rad 18 KW - ncRNAs KW - neurogranin KW - nitric oxide synthases KW - noncoding RNAs KW - open reading frame KW - phosphatase and tensin homologue induced putative kinase 1 KW - polycomb repressive complex 2 KW - protein coding gene KW - retinal noncoding RNA 2 KW - serial analysis of gene expression KW - sonic hedgehog KW - taurine upregulated gene 1 KW - wilde type Cu/Zn superoxide dismutase KW - wtSOD1 KW - β-site amyloid precursor protein-cleaving enzyme SP - 69 EP - 80 JF - Brain research bulletin JO - Brain Res Bull VL - 97 N2 - Long noncoding RNAs (lncRNAs) have been attracting immense research interest, while only a handful of lncRNAs have been characterized thoroughly. Their involvement in the fundamental cellular processes including regulate gene expression at epigenetics, transcription, and post-transcription highlighted a central role in cell homeostasis. However, lncRNAs studies are still at a relatively early stage, their definition, conservation, functions, and action mechanisms remain fairly complicated. Here, we give a systematic and comprehensive summary of the existing knowledge of lncRNAs in order to provide a better understanding of this new studying field. lncRNAs play important roles in brain development, neuron function and maintenance, and neurodegenerative diseases are becoming increasingly evident. In this review, we also highlighted recent studies related lncRNAs in central nervous system (CNS) development and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), and elucidated some specific lncRNAs which may be important for understanding the pathophysiology of neurodegenerative diseases, also have the potential as therapeutic targets. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/23756188/Roles_of_long_noncoding_RNAs_in_brain_development_functional_diversification_and_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(13)00096-8 DB - PRIME DP - Unbound Medicine ER -