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Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study.
Ann Neurol. 1990 Jul; 28(1):43-9.AN

Abstract

Central motor conduction to the small hand muscles was investigated in 59 patients with peroneal muscular atrophy and hereditary spastic paraplegia (HSP) by using transcranial magnetic brain stimulation. These comprised 20 patients with type I hereditary motor and sensory neuropathy (HMSN I), 15 with type II (HMSN II), 4 with HMSN I and 10 with HMSN II with associated pyramidal features, and 10 with the "pure" form of HSP. Central motor conduction was usually normal in HMSN I, HMSN II, and HSP. In HMSN I with pyramidal signs, central motor conduction time was greatly prolonged bilaterally. This result may reflect an associated involvement of the central motor pathways in these patients. In HMSN II with accompanying pyramidal features, 6 of the 10 patients had abnormal central motor conduction, although conduction times were only slightly prolonged, suggesting a different pathophysiological pattern.

Authors+Show Affiliations

National Hospital, Queen Square, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2375632

Citation

Claus, D, et al. "Hereditary Motor and Sensory Neuropathies and Hereditary Spastic Paraplegia: a Magnetic Stimulation Study." Annals of Neurology, vol. 28, no. 1, 1990, pp. 43-9.
Claus D, Waddy HM, Harding AE, et al. Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study. Ann Neurol. 1990;28(1):43-9.
Claus, D., Waddy, H. M., Harding, A. E., Murray, N. M., & Thomas, P. K. (1990). Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study. Annals of Neurology, 28(1), 43-9.
Claus D, et al. Hereditary Motor and Sensory Neuropathies and Hereditary Spastic Paraplegia: a Magnetic Stimulation Study. Ann Neurol. 1990;28(1):43-9. PubMed PMID: 2375632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study. AU - Claus,D, AU - Waddy,H M, AU - Harding,A E, AU - Murray,N M, AU - Thomas,P K, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 43 EP - 9 JF - Annals of neurology JO - Ann Neurol VL - 28 IS - 1 N2 - Central motor conduction to the small hand muscles was investigated in 59 patients with peroneal muscular atrophy and hereditary spastic paraplegia (HSP) by using transcranial magnetic brain stimulation. These comprised 20 patients with type I hereditary motor and sensory neuropathy (HMSN I), 15 with type II (HMSN II), 4 with HMSN I and 10 with HMSN II with associated pyramidal features, and 10 with the "pure" form of HSP. Central motor conduction was usually normal in HMSN I, HMSN II, and HSP. In HMSN I with pyramidal signs, central motor conduction time was greatly prolonged bilaterally. This result may reflect an associated involvement of the central motor pathways in these patients. In HMSN II with accompanying pyramidal features, 6 of the 10 patients had abnormal central motor conduction, although conduction times were only slightly prolonged, suggesting a different pathophysiological pattern. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/2375632/Hereditary_motor_and_sensory_neuropathies_and_hereditary_spastic_paraplegia:_a_magnetic_stimulation_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1990&volume=28&issue=1&spage=43 DB - PRIME DP - Unbound Medicine ER -