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Serum hepcidin levels in Helicobacter pylori-infected children with iron-deficiency anemia: a case-control study.
Ann Hematol. 2013 Nov; 92(11):1477-83.AH

Abstract

Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of systemic iron homeostasis. Hepcidin integrates signals from diverse physiological inputs, forming a key connection between iron trafficking and response to infection. In this study, we aimed to investigate whether Helicobacter pylori infection modulates serum hepcidin level and response to oral iron therapy in children with iron-deficiency anemia. This was a case-control study including 60 children with iron-deficiency anemia (IDA; 30 H. pylori infected and 30 H. pylori noninfected) and 30 healthy children with comparable age and gender as the control group. Iron parameters including serum iron, ferritin, transferrin, total iron binding capacity, and transferrin saturation and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. Compared to the control group, serum hepcidin was significantly lower in H. pylori-noninfected children with IDA (P < 0.01) and significantly higher in H. pylori-infected children with IDA (P < 0.01). Hepcidin increased significantly in noninfected children with IDA after 3 months of oral iron therapy (P < 0.01). On the other hand, H. pylori-infected children showed nonsignificant change in hepcidin level after oral iron therapy (P > 0.05). Although hepcidin showed significant positive correlations with serum ferritin, hemoglobin (Hb), iron, and transferrin saturation in noninfected children with IDA (P < 0.01), it showed significant negative correlations with serum ferritin, Hb, iron, and transferrin saturation in H. pylori-infected children with IDA (P < 0.05). H. pylori infection upregulates serum hepcidin levels and was associated with diminished response to oral iron therapy in children with iron-deficiency anemia.

Authors+Show Affiliations

Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt, seham_azab@yahoo.com.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23760782

Citation

Azab, Seham F A., and Asmaa M H. Esh. "Serum Hepcidin Levels in Helicobacter Pylori-infected Children With Iron-deficiency Anemia: a Case-control Study." Annals of Hematology, vol. 92, no. 11, 2013, pp. 1477-83.
Azab SF, Esh AM. Serum hepcidin levels in Helicobacter pylori-infected children with iron-deficiency anemia: a case-control study. Ann Hematol. 2013;92(11):1477-83.
Azab, S. F., & Esh, A. M. (2013). Serum hepcidin levels in Helicobacter pylori-infected children with iron-deficiency anemia: a case-control study. Annals of Hematology, 92(11), 1477-83. https://doi.org/10.1007/s00277-013-1813-2
Azab SF, Esh AM. Serum Hepcidin Levels in Helicobacter Pylori-infected Children With Iron-deficiency Anemia: a Case-control Study. Ann Hematol. 2013;92(11):1477-83. PubMed PMID: 23760782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum hepcidin levels in Helicobacter pylori-infected children with iron-deficiency anemia: a case-control study. AU - Azab,Seham F A, AU - Esh,Asmaa M H, Y1 - 2013/06/13/ PY - 2013/03/29/received PY - 2013/06/04/accepted PY - 2013/6/14/entrez PY - 2013/6/14/pubmed PY - 2013/12/16/medline SP - 1477 EP - 83 JF - Annals of hematology JO - Ann Hematol VL - 92 IS - 11 N2 - Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of systemic iron homeostasis. Hepcidin integrates signals from diverse physiological inputs, forming a key connection between iron trafficking and response to infection. In this study, we aimed to investigate whether Helicobacter pylori infection modulates serum hepcidin level and response to oral iron therapy in children with iron-deficiency anemia. This was a case-control study including 60 children with iron-deficiency anemia (IDA; 30 H. pylori infected and 30 H. pylori noninfected) and 30 healthy children with comparable age and gender as the control group. Iron parameters including serum iron, ferritin, transferrin, total iron binding capacity, and transferrin saturation and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. Compared to the control group, serum hepcidin was significantly lower in H. pylori-noninfected children with IDA (P < 0.01) and significantly higher in H. pylori-infected children with IDA (P < 0.01). Hepcidin increased significantly in noninfected children with IDA after 3 months of oral iron therapy (P < 0.01). On the other hand, H. pylori-infected children showed nonsignificant change in hepcidin level after oral iron therapy (P > 0.05). Although hepcidin showed significant positive correlations with serum ferritin, hemoglobin (Hb), iron, and transferrin saturation in noninfected children with IDA (P < 0.01), it showed significant negative correlations with serum ferritin, Hb, iron, and transferrin saturation in H. pylori-infected children with IDA (P < 0.05). H. pylori infection upregulates serum hepcidin levels and was associated with diminished response to oral iron therapy in children with iron-deficiency anemia. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/23760782/Serum_hepcidin_levels_in_Helicobacter_pylori_infected_children_with_iron_deficiency_anemia:_a_case_control_study_ L2 - https://dx.doi.org/10.1007/s00277-013-1813-2 DB - PRIME DP - Unbound Medicine ER -