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Highly diversified coronaviruses in neotropical bats.
J Gen Virol. 2013 Sep; 94(Pt 9):1984-1994.JG

Abstract

Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analysed faecal, blood and intestine specimens from 1562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected in 50 bats representing nine different species, both frugivorous and insectivorous. These bat CoVs were unrelated to known human or animal pathogens, indicating an absence of recent zoonotic spill-over events. Based on RNA-dependent RNA polymerase (RdRp)-based grouping units (RGUs) as a surrogate for CoV species identification, the 50 viruses represented five different alphacoronavirus RGUs and two betacoronavirus RGUs. Closely related alphacoronaviruses were detected in Carollia perspicillata and C. brevicauda across a geographical distance exceeding 5600 km. Our study expands the knowledge on CoV diversity in neotropical bats and emphasizes the association of distinct CoVs and bat host genera.

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Authors+Show Affiliations

Corman VM
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Rasche A
University of Veterinary Medicine Hannover, Foundation, Hannover, Germany. Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Diallo TD
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Cottontail VM
Institute of Experimental Ecology, University of Ulm, Ulm, Germany.
Stöcker A
Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil.
Souza BFCD
Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil.
Corrêa JI
Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil.
Carneiro AJB
School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.
Franke CR
School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil.
Nagy M
Museum für Naturkunde, Leibniz Institute for Research on Evolution and Biodiversity, Berlin, Germany.
Metz M
Fondazione Edmund Mach, Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, S. Michele all'Adige, Italy.
Knörnschild M
Institute of Experimental Ecology, University of Ulm, Ulm, Germany.
Kalko EKV
Smithsonian Tropical Research Institute, Balboa, Panama. Institute of Experimental Ecology, University of Ulm, Ulm, Germany.
Ghanem SJ
Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Morales KDS
Instituto Internacional en Conservación y Manejo de Vida Silvestre, Universidad Nacional, Heredia, Costa Rica.
Salsamendi E
Department of Zoology and Animal Cell Biology, University of the Basque Country, Bilbao, The Basque Country. Institute of Experimental Ecology, University of Ulm, Ulm, Germany.
Spínola M
Instituto Internacional en Conservación y Manejo de Vida Silvestre, Universidad Nacional, Heredia, Costa Rica.
Herrler G
University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Voigt CC
Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Tschapka M
Smithsonian Tropical Research Institute, Balboa, Panama. Institute of Experimental Ecology, University of Ulm, Ulm, Germany.
Drosten C
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Drexler JF
Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.

MeSH

AmericasAnimalsBloodChiropteraCluster AnalysisCoronavirusFecesGenetic VariationIntestinesMolecular Sequence DataPhylogeographyRNA, ViralRNA-Dependent RNA PolymeraseSequence Analysis, DNA

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23761408

Citation

Corman, Victor Max, et al. "Highly Diversified Coronaviruses in Neotropical Bats." The Journal of General Virology, vol. 94, no. Pt 9, 2013, pp. 1984-1994.
Corman VM, Rasche A, Diallo TD, et al. Highly diversified coronaviruses in neotropical bats. J Gen Virol. 2013;94(Pt 9):1984-1994.
Corman, V. M., Rasche, A., Diallo, T. D., Cottontail, V. M., Stöcker, A., Souza, B. F. C. D., Corrêa, J. I., Carneiro, A. J. B., Franke, C. R., Nagy, M., Metz, M., Knörnschild, M., Kalko, E. K. V., Ghanem, S. J., Morales, K. D. S., Salsamendi, E., Spínola, M., Herrler, G., Voigt, C. C., ... Drexler, J. F. (2013). Highly diversified coronaviruses in neotropical bats. The Journal of General Virology, 94(Pt 9), 1984-1994. https://doi.org/10.1099/vir.0.054841-0
Corman VM, et al. Highly Diversified Coronaviruses in Neotropical Bats. J Gen Virol. 2013;94(Pt 9):1984-1994. PubMed PMID: 23761408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly diversified coronaviruses in neotropical bats. AU - Corman,Victor Max, AU - Rasche,Andrea, AU - Diallo,Thierno Diawo, AU - Cottontail,Veronika M, AU - Stöcker,Andreas, AU - Souza,Breno Frederico de Carvalho Dominguez, AU - Corrêa,Jefferson Ivan, AU - Carneiro,Aroldo José Borges, AU - Franke,Carlos Roberto, AU - Nagy,Martina, AU - Metz,Markus, AU - Knörnschild,Mirjam, AU - Kalko,Elisabeth K V, AU - Ghanem,Simon J, AU - Morales,Karen D Sibaja, AU - Salsamendi,Egoitz, AU - Spínola,Manuel, AU - Herrler,Georg, AU - Voigt,Christian C, AU - Tschapka,Marco, AU - Drosten,Christian, AU - Drexler,Jan Felix, Y1 - 2013/06/12/ PY - 2013/6/14/entrez PY - 2013/6/14/pubmed PY - 2013/11/7/medline SP - 1984 EP - 1994 JF - The Journal of general virology JO - J Gen Virol VL - 94 IS - Pt 9 N2 - Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analysed faecal, blood and intestine specimens from 1562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected in 50 bats representing nine different species, both frugivorous and insectivorous. These bat CoVs were unrelated to known human or animal pathogens, indicating an absence of recent zoonotic spill-over events. Based on RNA-dependent RNA polymerase (RdRp)-based grouping units (RGUs) as a surrogate for CoV species identification, the 50 viruses represented five different alphacoronavirus RGUs and two betacoronavirus RGUs. Closely related alphacoronaviruses were detected in Carollia perspicillata and C. brevicauda across a geographical distance exceeding 5600 km. Our study expands the knowledge on CoV diversity in neotropical bats and emphasizes the association of distinct CoVs and bat host genera. SN - 1465-2099 UR - https://www.unboundmedicine.com/medline/citation/23761408/Highly_diversified_coronaviruses_in_neotropical_bats_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.054841-0 DB - PRIME DP - Unbound Medicine ER -