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Effect of beclomethasone dipropionate on the bronchial responsiveness to propranolol in asthmatics.
Chest. 1990 Aug; 98(2):263-5.Chest

Abstract

The effect of four weeks of treatment with beclomethasone dipropionate (BDP, 500 micrograms twice daily) on the bronchial responsiveness to propranolol was examined in 16 patients with mild asthma in a placebo-controlled, double-blind crossover study. Propranolol was inhaled in doubling concentrations and the results were expressed as the cumulative dose producing a 20 percent fall in FEV1 (PC20). After four weeks of treatment with BDP, the mean FEV1 increased from 82.0 percent predicted to 88.1 percent predicted. The difference was significant (p less than 0.001). Treatment with BDP did not significantly change the responsiveness to propranolol, the geometric mean PC20 being 3.17 mg/ml before and 3.64 mg/ml after BDP treatment. The recovery of FEV1 was faster after 60 minutes of BDP treatment in comparison with placebo treatment (beyond 90 minutes). This study suggests that BDP treatment is unable to reduce bronchial responsiveness to propranolol but can accelerate the recovery of bronchoconstriction induced by propranolol in asthmatic patients.

Authors+Show Affiliations

Carpentiere G
Medical Clinic Institute, University of Palermo, Italy.
Castello F
No affiliation info available
Marino S
No affiliation info available

MeSH

Administration, InhalationAdultAsthmaBeclomethasoneBronchial Provocation TestsBronchial SpasmDouble-Blind MethodFemaleForced Expiratory VolumeHumansMalePropranololRandom AllocationTime Factors

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2376155

Citation

Carpentiere, G, et al. "Effect of Beclomethasone Dipropionate On the Bronchial Responsiveness to Propranolol in Asthmatics." Chest, vol. 98, no. 2, 1990, pp. 263-5.
Carpentiere G, Castello F, Marino S. Effect of beclomethasone dipropionate on the bronchial responsiveness to propranolol in asthmatics. Chest. 1990;98(2):263-5.
Carpentiere, G., Castello, F., & Marino, S. (1990). Effect of beclomethasone dipropionate on the bronchial responsiveness to propranolol in asthmatics. Chest, 98(2), 263-5.
Carpentiere G, Castello F, Marino S. Effect of Beclomethasone Dipropionate On the Bronchial Responsiveness to Propranolol in Asthmatics. Chest. 1990;98(2):263-5. PubMed PMID: 2376155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beclomethasone dipropionate on the bronchial responsiveness to propranolol in asthmatics. AU - Carpentiere,G, AU - Castello,F, AU - Marino,S, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 263 EP - 5 JF - Chest JO - Chest VL - 98 IS - 2 N2 - The effect of four weeks of treatment with beclomethasone dipropionate (BDP, 500 micrograms twice daily) on the bronchial responsiveness to propranolol was examined in 16 patients with mild asthma in a placebo-controlled, double-blind crossover study. Propranolol was inhaled in doubling concentrations and the results were expressed as the cumulative dose producing a 20 percent fall in FEV1 (PC20). After four weeks of treatment with BDP, the mean FEV1 increased from 82.0 percent predicted to 88.1 percent predicted. The difference was significant (p less than 0.001). Treatment with BDP did not significantly change the responsiveness to propranolol, the geometric mean PC20 being 3.17 mg/ml before and 3.64 mg/ml after BDP treatment. The recovery of FEV1 was faster after 60 minutes of BDP treatment in comparison with placebo treatment (beyond 90 minutes). This study suggests that BDP treatment is unable to reduce bronchial responsiveness to propranolol but can accelerate the recovery of bronchoconstriction induced by propranolol in asthmatic patients. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/2376155/Effect_of_beclomethasone_dipropionate_on_the_bronchial_responsiveness_to_propranolol_in_asthmatics_ DB - PRIME DP - Unbound Medicine ER -