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Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial.
Food Chem Toxicol. 2013 Sep; 59:90-5.FC

Abstract

The protective effects of puerarin on liver damage were evaluated by carbon tetrachloride (CCl₄)-induced hepatotoxicity in rats. Male rats were orally treated with puerarin daily, and received CCl₄ intraperitoneally twice a week for 4 weeks. Our results showed that puerarin at doses of 50, 100, and 200 mg/kg b. w. significantly reduced the elevated activities of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase at least 15%, 17%, 14% and 18%, respectively. In addition, puerarin at different doses significantly decreased (p<0.05) the level of hepatic thiobarbituric acid reactive substances compared to the CCl₄-treated group. Furthermore, the treatment of puerarin was also found to significantly increase the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glutathione content at least 40%, 12%, 25%, 52%, 17% and 44% in the liver of CCl₄-treated rats, respectively. Liver histopathology also showed that puerarin reduced the incidence of liver lesions induced by CCl₄. The results suggest that puerarin exhibits potent hepatoprotective effects on CCl₄-induced liver damages in rats, and that the hepatoprotective effects of puerarin may be due to both the inhibition of lipid peroxidation and to increase of antioxidant enzymes activity.

Authors+Show Affiliations

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China. xdz_zjtcm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23764356

Citation

Xia, Dao-Zong, et al. "Hepatoprotective Activity of Puerarin Against Carbon Tetrachloride-induced Injuries in Rats: a Randomized Controlled Trial." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 59, 2013, pp. 90-5.
Xia DZ, Zhang PH, Fu Y, et al. Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. Food Chem Toxicol. 2013;59:90-5.
Xia, D. Z., Zhang, P. H., Fu, Y., Yu, W. F., & Ju, M. T. (2013). Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 59, 90-5. https://doi.org/10.1016/j.fct.2013.05.055
Xia DZ, et al. Hepatoprotective Activity of Puerarin Against Carbon Tetrachloride-induced Injuries in Rats: a Randomized Controlled Trial. Food Chem Toxicol. 2013;59:90-5. PubMed PMID: 23764356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. AU - Xia,Dao-Zong, AU - Zhang,Pei-Hua, AU - Fu,Yan, AU - Yu,Wei-Fu, AU - Ju,Meng-Ting, Y1 - 2013/06/10/ PY - 2013/02/20/received PY - 2013/05/11/revised PY - 2013/05/13/accepted PY - 2013/6/15/entrez PY - 2013/6/15/pubmed PY - 2014/3/29/medline KW - ALP KW - ALT KW - AST KW - Antioxidant KW - CAT KW - Carbon tetrachloride KW - GPx KW - GR KW - GSH KW - GST KW - Hepatoprotection KW - Hepatotoxicity KW - LDH KW - Puerarin KW - SOD KW - TBARS KW - alanine aminotransferase KW - alkaline phosphatase KW - aspartate aminotransferase KW - catalase KW - glutathione KW - glutathione peroxidase KW - glutathione reductase KW - glutathione-S-transferase KW - lactate dehydrogenase KW - superoxide dismutase KW - thiobarbituric acid reactive substances SP - 90 EP - 5 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 59 N2 - The protective effects of puerarin on liver damage were evaluated by carbon tetrachloride (CCl₄)-induced hepatotoxicity in rats. Male rats were orally treated with puerarin daily, and received CCl₄ intraperitoneally twice a week for 4 weeks. Our results showed that puerarin at doses of 50, 100, and 200 mg/kg b. w. significantly reduced the elevated activities of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase at least 15%, 17%, 14% and 18%, respectively. In addition, puerarin at different doses significantly decreased (p<0.05) the level of hepatic thiobarbituric acid reactive substances compared to the CCl₄-treated group. Furthermore, the treatment of puerarin was also found to significantly increase the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glutathione content at least 40%, 12%, 25%, 52%, 17% and 44% in the liver of CCl₄-treated rats, respectively. Liver histopathology also showed that puerarin reduced the incidence of liver lesions induced by CCl₄. The results suggest that puerarin exhibits potent hepatoprotective effects on CCl₄-induced liver damages in rats, and that the hepatoprotective effects of puerarin may be due to both the inhibition of lipid peroxidation and to increase of antioxidant enzymes activity. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/23764356/Hepatoprotective_activity_of_puerarin_against_carbon_tetrachloride_induced_injuries_in_rats:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(13)00361-X DB - PRIME DP - Unbound Medicine ER -