TY - JOUR T1 - Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates. AU - Vegge,Andreas, AU - Thymann,Thomas, AU - Lund,Pernille, AU - Stoll,Barbara, AU - Bering,Stine B, AU - Hartmann,Bolette, AU - Jelsing,Jacob, AU - Qvist,Niels, AU - Burrin,Douglas G, AU - Jeppesen,Palle B, AU - Holst,Jens J, AU - Sangild,Per T, Y1 - 2013/06/13/ PY - 2013/6/15/entrez PY - 2013/6/15/pubmed PY - 2013/10/29/medline KW - glucagon-like peptide-2 KW - intestine KW - neonatal short bowel syndrome KW - premature SP - G277 EP - 85 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 305 IS - 4 N2 - Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P < 0.05). These findings were supported by a 200% increase in sucrase and maltase activities, a 50% increase in small intestinal epithelial volume (P < 0.05), as well as increased DNA and protein contents and increased total protein synthesis rate in SBS+GLP-2 vs. SBS pigs (+100%, P < 0.05). Following intestinal resection in preterm pigs, GLP-2 induced structural and functional adaptation, resulting in a higher relative absorption of fluid and macronutrients. GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/23764891/Glucagon_like_peptide_2_induces_rapid_digestive_adaptation_following_intestinal_resection_in_preterm_neonates_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00064.2013?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -