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Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes.
Scand J Clin Lab Invest. 2013 Aug; 73(5):422-7.SJ

Abstract

BACKGROUND/AIMS

In this present study, we aimed: (i) To clarify if prediabetes is associated with subclinical inflammation independent of underlying obesity, and (ii) to evaluate the effect of postload glucose concentration on subclinical inflammation markers in a group of patients with elevated fasting glucose.

MATERIAL AND METHODS

In a cohort of 165 patients with newly detected fasting hyperglycemia, according to 75 g oral glucose tolerance test (OGTT), subjects were classified either as newly diagnosed type 2 diabetes (diabetes group, n = 40), impaired fasting glucose (IFG) plus impaired glucose tolerance (IGT) (IFG/IGT group, n = 42) or IFG only (IFG group, n = 83). A control group (n = 47) consisted of age- and body mass index (BMI)-matched healthy subjects with a normal OGTT. Circulating concentrations of lipids, insulin, interleukin-6 (IL-6), interleukin-8 (IL-8) and high sensitive C-reactive protein (hsCRP) were measured. HOMA index was calculated.

RESULTS

Subclinical inflammation markers were elevated in patients with diabetes and IFG/IGT compared to healthy controls and also IFG patients (diabetes vs. control: p < 0.05 for hsCRP, IL-8, and IL-6; IFG/IGT vs. control: p < 0.05 for hsCRP, and IL-6; diabetes vs. IFG: p < 0.05 for hsCRP, and IL-6; IFG/IGT vs. IFG: p < 0.05 for hsCRP, and IL-6). In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6).

CONCLUSION

Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation which is mostly driven by postload glucose concentrations.

Authors+Show Affiliations

Department of Clinical Biochemistry, Tepecik Training and Research Hospital, Izmir, Turkey. ayfercolak@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23767858

Citation

Colak, Ayfer, et al. "Postload Hyperglycemia Is Associated With Increased Subclinical Inflammation in Patients With Prediabetes." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 73, no. 5, 2013, pp. 422-7.
Colak A, Akinci B, Diniz G, et al. Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes. Scand J Clin Lab Invest. 2013;73(5):422-7.
Colak, A., Akinci, B., Diniz, G., Turkon, H., Ergonen, F., Yalcin, H., & Coker, I. (2013). Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes. Scandinavian Journal of Clinical and Laboratory Investigation, 73(5), 422-7. https://doi.org/10.3109/00365513.2013.798870
Colak A, et al. Postload Hyperglycemia Is Associated With Increased Subclinical Inflammation in Patients With Prediabetes. Scand J Clin Lab Invest. 2013;73(5):422-7. PubMed PMID: 23767858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postload hyperglycemia is associated with increased subclinical inflammation in patients with prediabetes. AU - Colak,Ayfer, AU - Akinci,Baris, AU - Diniz,Gulden, AU - Turkon,Hakan, AU - Ergonen,Faruk, AU - Yalcin,Hulya, AU - Coker,Isil, Y1 - 2013/06/14/ PY - 2013/6/18/entrez PY - 2013/6/19/pubmed PY - 2014/2/27/medline SP - 422 EP - 7 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 73 IS - 5 N2 - BACKGROUND/AIMS: In this present study, we aimed: (i) To clarify if prediabetes is associated with subclinical inflammation independent of underlying obesity, and (ii) to evaluate the effect of postload glucose concentration on subclinical inflammation markers in a group of patients with elevated fasting glucose. MATERIAL AND METHODS: In a cohort of 165 patients with newly detected fasting hyperglycemia, according to 75 g oral glucose tolerance test (OGTT), subjects were classified either as newly diagnosed type 2 diabetes (diabetes group, n = 40), impaired fasting glucose (IFG) plus impaired glucose tolerance (IGT) (IFG/IGT group, n = 42) or IFG only (IFG group, n = 83). A control group (n = 47) consisted of age- and body mass index (BMI)-matched healthy subjects with a normal OGTT. Circulating concentrations of lipids, insulin, interleukin-6 (IL-6), interleukin-8 (IL-8) and high sensitive C-reactive protein (hsCRP) were measured. HOMA index was calculated. RESULTS: Subclinical inflammation markers were elevated in patients with diabetes and IFG/IGT compared to healthy controls and also IFG patients (diabetes vs. control: p < 0.05 for hsCRP, IL-8, and IL-6; IFG/IGT vs. control: p < 0.05 for hsCRP, and IL-6; diabetes vs. IFG: p < 0.05 for hsCRP, and IL-6; IFG/IGT vs. IFG: p < 0.05 for hsCRP, and IL-6). In multiple regression analysis, postload glucose concentration was independently associated with circulating hsCRP and IL-6 concentrations when the data was controlled for age, gender, BMI and lipid concentrations (p < 0.05 for hsCRP, and IL-6). CONCLUSION: Our results suggest that patients with prediabetes, independent of underlying obesity, have increased concentrations of subclinical inflammation which is mostly driven by postload glucose concentrations. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/23767858/Postload_hyperglycemia_is_associated_with_increased_subclinical_inflammation_in_patients_with_prediabetes_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365513.2013.798870 DB - PRIME DP - Unbound Medicine ER -