Tags

Type your tag names separated by a space and hit enter

Synthesis and on-target antibacterial activity of novel 3-elongated arylalkoxybenzamide derivatives as inhibitors of the bacterial cell division protein FtsZ.
Bioorg Med Chem Lett. 2013 Jul 15; 23(14):4076-9.BM

Abstract

Novel 3-elongated arylalkoxybenzamide derivatives were designed, synthesized and evaluated for their cell division inhibitory activity and antibacterial activity. Among them, the subseries of 3-alkyloxybenzamide derivatives exhibited greatly improved on-target activity against Bacillus subtilis and Staphylococcus aureus, and remarkably increased antibacterial activity against B. subtilis ATCC9372, penicillin-susceptible S. aureus ATCC25923, methicillin-resistant S. aureus ATCC29213 (MRSA) and penicillin-resistant S. aureus PR compared with 3-methoxybenzamide. In contrast, the subseries of 3-phenoxyaklyloxybenzamide, 3-heteroarylalkyloxybenzamide and 3-heteroarylthioalkyloxybenzamide derivatives only showed a significant improvement in on-target activity and antibacterial activity against B. subtilis ATCC9372.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ma S
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan 250012, PR China.
Cong C
No affiliation info available
Meng X
No affiliation info available
Cao S
No affiliation info available
Yang H
No affiliation info available
Guo Y
No affiliation info available
Lu X
No affiliation info available
Ma S
No affiliation info available

MeSH

Anti-Bacterial AgentsBacillus subtilisBacterial ProteinsBenzamidesCytoskeletal ProteinsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23770057

Citation

Ma, Siti, et al. "Synthesis and On-target Antibacterial Activity of Novel 3-elongated Arylalkoxybenzamide Derivatives as Inhibitors of the Bacterial Cell Division Protein FtsZ." Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 14, 2013, pp. 4076-9.
Ma S, Cong C, Meng X, et al. Synthesis and on-target antibacterial activity of novel 3-elongated arylalkoxybenzamide derivatives as inhibitors of the bacterial cell division protein FtsZ. Bioorg Med Chem Lett. 2013;23(14):4076-9.
Ma, S., Cong, C., Meng, X., Cao, S., Yang, H., Guo, Y., Lu, X., & Ma, S. (2013). Synthesis and on-target antibacterial activity of novel 3-elongated arylalkoxybenzamide derivatives as inhibitors of the bacterial cell division protein FtsZ. Bioorganic & Medicinal Chemistry Letters, 23(14), 4076-9. https://doi.org/10.1016/j.bmcl.2013.05.056
Ma S, et al. Synthesis and On-target Antibacterial Activity of Novel 3-elongated Arylalkoxybenzamide Derivatives as Inhibitors of the Bacterial Cell Division Protein FtsZ. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4076-9. PubMed PMID: 23770057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and on-target antibacterial activity of novel 3-elongated arylalkoxybenzamide derivatives as inhibitors of the bacterial cell division protein FtsZ. AU - Ma,Siti, AU - Cong,Chao, AU - Meng,Xiaohui, AU - Cao,Shasha, AU - Yang,Hongkun, AU - Guo,Yuanyuan, AU - Lu,Xueyi, AU - Ma,Shutao, Y1 - 2013/05/24/ PY - 2013/01/26/received PY - 2013/04/30/revised PY - 2013/05/16/accepted PY - 2013/6/18/entrez PY - 2013/6/19/pubmed PY - 2014/1/22/medline SP - 4076 EP - 9 JF - Bioorganic & medicinal chemistry letters JO - Bioorg Med Chem Lett VL - 23 IS - 14 N2 - Novel 3-elongated arylalkoxybenzamide derivatives were designed, synthesized and evaluated for their cell division inhibitory activity and antibacterial activity. Among them, the subseries of 3-alkyloxybenzamide derivatives exhibited greatly improved on-target activity against Bacillus subtilis and Staphylococcus aureus, and remarkably increased antibacterial activity against B. subtilis ATCC9372, penicillin-susceptible S. aureus ATCC25923, methicillin-resistant S. aureus ATCC29213 (MRSA) and penicillin-resistant S. aureus PR compared with 3-methoxybenzamide. In contrast, the subseries of 3-phenoxyaklyloxybenzamide, 3-heteroarylalkyloxybenzamide and 3-heteroarylthioalkyloxybenzamide derivatives only showed a significant improvement in on-target activity and antibacterial activity against B. subtilis ATCC9372. SN - 1464-3405 UR - https://www.unboundmedicine.com/medline/citation/23770057/Synthesis_and_on_target_antibacterial_activity_of_novel_3_elongated_arylalkoxybenzamide_derivatives_as_inhibitors_of_the_bacterial_cell_division_protein_FtsZ_ DB - PRIME DP - Unbound Medicine ER -