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Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis.

Abstract

AIM

To compare patients with advanced stage endometriosis with control patients without endometriosis with respect to serum Copper (Cu) and Ceruloplasmin (Cp) levels and oxidative stress markers in order to evaluate the importance of these parameters in the pathogenesis of endometriosis.

PATIENTS AND METHODS

A total of 72 women who underwent laparoscopy or laparotomy for evaluation of infertility, pelvic pain, pelvic mass, tubal ligation or endometriosis were enrolled for this prospective clinical study. Patients were divided into two groups by visual diagnosis at surgery and histological confirmation of endometriosis: control patients (n=41) without endometriosis and study group (n=31) with stage III/IV (advanced stage) endometriosis. Serum Cu, Cp, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), malondialdehyde (MDA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were compared between the two groups. Correlations between Cu, Cp and oxidative stress markers were determined.

RESULTS

Serum TOS, OSI, Cu, Cp, TG, TC, LDL were significantly higher, whereas TAS, PON-1 activity and HDL were significantly lower, in women with advanced-stage endometriosis than in control groups. There was no difference in serum MDA activities between the two groups. Positive correlations were found between Cu and TOS, Cu and OSI, Cu and Cp, while a negative correlation was found between Cu and PON-1 in the advanced-stage endometriosis group. Positive correlations were found between Cp and TOS, and Cp and OSI in the advanced-stage endometriosis group.

CONCLUSIONS

Cu and Cp appear to be associated with the etiopathogenesis of and oxidative stress in endometriosis.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynaecology, Dicle University School of Medicine, Diyarbakir, Turkey. abdulkadirturgut@gmail.com

    , , , ,

    Source

    MeSH

    Adult
    Case-Control Studies
    Ceruloplasmin
    Copper
    Endometriosis
    Female
    Humans
    Lipoproteins, HDL
    Lipoproteins, LDL
    Oxidative Stress
    Prospective Studies

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23771536

    Citation

    Turgut, A, et al. "Copper, Ceruloplasmin and Oxidative Stress in Patients With Advanced-stage Endometriosis." European Review for Medical and Pharmacological Sciences, vol. 17, no. 11, 2013, pp. 1472-8.
    Turgut A, Özler A, Görük NY, et al. Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis. Eur Rev Med Pharmacol Sci. 2013;17(11):1472-8.
    Turgut, A., Özler, A., Görük, N. Y., Tunc, S. Y., Evliyaoglu, O., & Gül, T. (2013). Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis. European Review for Medical and Pharmacological Sciences, 17(11), pp. 1472-8.
    Turgut A, et al. Copper, Ceruloplasmin and Oxidative Stress in Patients With Advanced-stage Endometriosis. Eur Rev Med Pharmacol Sci. 2013;17(11):1472-8. PubMed PMID: 23771536.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis. AU - Turgut,A, AU - Özler,A, AU - Görük,N Y, AU - Tunc,S Y, AU - Evliyaoglu,O, AU - Gül,T, PY - 2013/6/18/entrez PY - 2013/6/19/pubmed PY - 2013/9/5/medline SP - 1472 EP - 8 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 17 IS - 11 N2 - AIM: To compare patients with advanced stage endometriosis with control patients without endometriosis with respect to serum Copper (Cu) and Ceruloplasmin (Cp) levels and oxidative stress markers in order to evaluate the importance of these parameters in the pathogenesis of endometriosis. PATIENTS AND METHODS: A total of 72 women who underwent laparoscopy or laparotomy for evaluation of infertility, pelvic pain, pelvic mass, tubal ligation or endometriosis were enrolled for this prospective clinical study. Patients were divided into two groups by visual diagnosis at surgery and histological confirmation of endometriosis: control patients (n=41) without endometriosis and study group (n=31) with stage III/IV (advanced stage) endometriosis. Serum Cu, Cp, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), malondialdehyde (MDA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were compared between the two groups. Correlations between Cu, Cp and oxidative stress markers were determined. RESULTS: Serum TOS, OSI, Cu, Cp, TG, TC, LDL were significantly higher, whereas TAS, PON-1 activity and HDL were significantly lower, in women with advanced-stage endometriosis than in control groups. There was no difference in serum MDA activities between the two groups. Positive correlations were found between Cu and TOS, Cu and OSI, Cu and Cp, while a negative correlation was found between Cu and PON-1 in the advanced-stage endometriosis group. Positive correlations were found between Cp and TOS, and Cp and OSI in the advanced-stage endometriosis group. CONCLUSIONS: Cu and Cp appear to be associated with the etiopathogenesis of and oxidative stress in endometriosis. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/23771536/Copper_ceruloplasmin_and_oxidative_stress_in_patients_with_advanced_stage_endometriosis_ L2 - http://www.europeanreview.org/article/4353 DB - PRIME DP - Unbound Medicine ER -